PITX2 and PFDN5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PITX2	PFDN5
Description		paired like homeodomain 2	prefoldin subunit 5
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm	Nucleus Cytoplasm Cytosol Prefoldin Complex Protein-containing Complex Intermediate Filament Cytoskeleton
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Sequence-specific DNA Binding Phosphoprotein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Amyloid-beta Binding Transcription Corepressor Activity Protein Binding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Vasculogenesis In Utero Embryonic Development Neuron Migration Extraocular Skeletal Muscle Development Outflow Tract Morphogenesis Atrioventricular Valve Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Pulmonary Myocardium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Heart Development Skeletal Muscle Tissue Development Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Animal Organ Morphogenesis Wnt Signaling Pathway Subthalamic Nucleus Development Hypothalamus Cell Migration Pituitary Gland Development Lung Development Regulation Of Cell Migration Embryonic Camera-type Eye Development Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Vascular Associated Smooth Muscle Cell Differentiation Deltoid Tuberosity Development Regulation Of Cell Population Proliferation Odontogenesis Camera-type Eye Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Embryonic Digestive Tract Morphogenesis System Development Cardiac Muscle Tissue Development Cardiac Muscle Cell Differentiation Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Digestive System Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Ventricular Septum Morphogenesis Left Lung Morphogenesis Pulmonary Vein Morphogenesis Superior Vena Cava Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Endodermal Digestive Tract Morphogenesis Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification	Regulation Of DNA-templated Transcription Protein Folding Negative Regulation Of DNA-templated Transcription Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Amyloid Fibril Formation RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly RNA Polymerase III Assembly
Pathways		TFAP2 (AP-2) family regulates transcription of other transcription factors	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases		Axenfeld-Rieger syndrome (ARS)
GWAS		Appendectomy ( 30392061) Atrial fibrillation ( 19597492 33990960 30061737 29892015 29290336 28416822 28416818 20173747 22544366) Atrial fibrillation/atrial flutter ( 17603472) Cardioembolic stroke (CCS and TOAST classification) ( 32047268) Cardioembolic stroke (CCS or TOAST classification) ( 32047268) Cardioembolic stroke (CCSc classification) ( 32047268) Cardioembolic stroke (CCSp classification) ( 32047268) Cardioembolic stroke (TOAST classification) ( 32047268) Cognitive decline rate in late mild cognitive impairment ( 26252872) Early onset atrial fibrillation ( 28460022) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma (primary open-angle) ( 33627673) Heart failure ( 31919418) Incident atrial fibrillation ( 28416818) Intraocular pressure ( 29235454) Ischemic stroke ( 24262325 26708676) Ischemic stroke (cardioembolic) ( 26708676 27068588) Lung cancer ( 28604730) Prevalent atrial fibrillation ( 28416818) Sick sinus syndrome ( 33580673) Smoking status (heavy vs never) ( 26423011) Stroke (ischemic) ( 23041239)
Interacting Genes		36 interacting genes: ATN1 CTNNB1 CYSRT1 DAZAP2 DYNLT1 HDAC1 HERC5 HEY1 HOXA1 KAT5 KRT34 KRTAP15-1 KRTAP19-5 KRTAP19-7 KRTAP3-3 KRTAP6-1 KRTAP7-1 LEF1 OIP5 PDLIM1 PFDN5 POU2AF1 PROP1 PSMB4 RBPMS SPMIP9 TINAGL1 TLE5 TRAF1 TRIB3 TRIM25 UFSP1 VGLL3 WWOX ZNF34 ZNHIT3	113 interacting genes: ABI2 ANKRD55 ATOSB BCAS2 BCL6 BHLHE40 BRMS1 C10orf55 C10orf62 C22orf39 CALCOCO2 CCDC198 CEBPA CIMIP1 CSPP1 DMRT3 DOK4 DOK5 EEIG1 ELK3 ESPNL FAAP20 FAM110A FAM221A FAM222B FAM90A1 GLRX3 GLYCTK GPANK1 GSTO2 GUCD1 HAPLN2 HHEX HOXB9 HOXC8 IKBKG IKZF3 IL16 INCA1 IRX2 IRX6 ITSN1 KCTD9 KDM1A KLHL38 KLHL42 LARP4 LNX1 MAP2K5 METTL21A MISP MRPL45 MYC MYOT MYOZ1 NEUROG2 NOXA1 NTAQ1 PATZ1 PAX9 PFDN6 PHF1 PHF24 PILRA PITX1 PITX2 POGZ PRKAB2 PRPF18 PRR35 PSMB4 PSMB8 PSME3 RIBC1 RIPPLY1 RSRC2 RUSC1 SAXO1 SAXO4 SCNM1 SDCBP SHISA6 SLAIN1 SMAP1 SMG9 SNAI1 SNRNP25 SNRPB SOHLH1 SPAG8 SPG21 SPMIP2 SPMIP4 SYCE1L SYT17 TAF6L TBX3 TCF19 TFG TLE5 TP73 TRAPPC6A TRIM28 TUBA1B TUBA3C VAX2 VEZF1 VGLL1 WDR25 WHR1 YPEL5 ZC2HC1C ZNF148
Entrez ID		5308	5204
HPRD ID		03328	05359
Ensembl ID		ENSG00000164093	ENSG00000123349
Uniprot IDs		Q99697	Q99471
PDB IDs		2L7F 2L7M 2LKX	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Transcription Coactivator Activity Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Regulator Complex Fungiform Papilla Formation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Hair Follicle Placode Formation Regulation Of Wnt Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Odontoblast Differentiation Positive Regulation Of Neuroepithelial Cell Differentiation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Odontoblast Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Beta-catenin-TCF Complex Maintenance Of Cell Polarity Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Epithelial To Mesenchymal Transition Positive Regulation Of Biosynthetic Process Regulation Of Neurogenesis Positive Regulation Of Transcription By RNA Polymerase II Cytoplasmic Stress Granule Negative Regulation Of Nucleobase-containing Compound Metabolic Process Odontogenesis Positive Regulation Of Macromolecule Metabolic Process Protein Binding Mesenchymal Cell Differentiation Host-mediated Perturbation Of Symbiont Process	Protein Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Pattern Specification Process MRF Binding Regionalization Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process E-box Binding Axonemal A Tubule Inner Sheath
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