PITX2 and HOXA1

Number of citations of the paper that reports this interaction (PMID 23088713)
3

Data Source:
BioGRID (affinity chromatography technology, protein complementation assay)

		PITX2	HOXA1
Gene Name		paired-like homeodomain 2	homeobox A1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleus
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Phosphoprotein Binding	Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Patterning Of Blood Vessels Vasculogenesis In Utero Embryonic Development Neuron Migration Extraocular Skeletal Muscle Development Atrioventricular Valve Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Pulmonary Myocardium Development Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Determination Of Left/right Symmetry Myoblast Fusion Male Gonad Development Female Gonad Development Response To Hormone Wnt Signaling Pathway Subthalamic Nucleus Development Hypothalamus Cell Migration Regulation Of Cell Migration Embryonic Camera-type Eye Development Response To Vitamin A Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Vascular Smooth Muscle Cell Differentiation Deltoid Tuberosity Development Odontogenesis Of Dentin-containing Tooth Odontogenesis Camera-type Eye Development Positive Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Embryonic Digestive Tract Morphogenesis Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Ventricular Septum Morphogenesis Left Lung Morphogenesis Pulmonary Vein Morphogenesis Superior Vena Cava Morphogenesis Endodermal Digestive Tract Morphogenesis Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification Positive Regulation Of Myoblast Proliferation	Transcription, DNA-templated Multicellular Organismal Development Sensory Perception Of Sound Optokinetic Behavior Motor Neuron Axon Guidance Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Rhombomere 3 Development Rhombomere 4 Development Rhombomere 5 Development Abducens Nerve Formation Facial Nerve Structural Organization Facial Nucleus Development Central Nervous System Neuron Differentiation Outer Ear Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Neurocranium Morphogenesis Inner Ear Development Artery Morphogenesis Regulation Of Behavior Cognition Neuromuscular Process Artery Development Semicircular Canal Formation Cellular Response To Retinoic Acid Cochlea Development Cochlea Morphogenesis
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 20173747 19597492 22544366) Atrial fibrillation/atrial flutter ( 17603472) Stroke (ischemic) ( 23041239)
Protein-Protein Interactions		10 interactors: CTNNB1 HDAC1 HERC5 HOXA1 KAT5 LEF1 PDLIM1 PROP1 TRIM25 ZNHIT3	79 interactors: ABHD17A ADAMTSL4 ALG13 BLZF1 C1orf94 CCDC33 CHIC2 CHRD CRACR2A DUSP22 EFEMP2 FAM154A FHL5 GATA1 GP9 GRN HOXD3 HSFY1 IKZF2 KDM1A KRT31 KRT38 KRT40 KRT81 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE3E LCE4A LGALS13 LIMS1 LNX2 LPXN MDFI MGAT5B N4BP2L2 NOTCH2NL PBX1 PBX2 PCSK5 PDCD6IP PIK3R1 PITX2 PKNOX1 PLSCR1 PLSCR4 PRMT6 PRRC2B RAB33A RBPMS RGS17 RGS20 SDCBP SPRY1 SUV39H1 TBC1D10C TCF3 TRAF1 TRAPPC6A TRIM42 TRIP6 ZZZ3
Entrez ID		5308	3198
HPRD ID		03328	00843
Ensembl ID		ENSG00000164093	ENSG00000105991
Uniprot IDs		Q99697	P49639
PDB IDs		2L7F 2L7M 2LKX
Enriched GO Terms of Interacting Partners?		Tongue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cytokine Production Regulation Of Cytokine Production Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Fungiform Papilla Formation Regulation Of Nitrogen Compound Metabolic Process Canonical Wnt Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Fungiform Papilla Morphogenesis Odontogenesis Of Dentin-containing Tooth Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Type I Interferon Production Fungiform Papilla Development Response To Lipid Positive Regulation Of Gene Expression Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Hair Follicle Placode Formation Odontogenesis Tongue Morphogenesis Organ Morphogenesis Response To Steroid Hormone Pattern Specification Process Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Limb Morphogenesis Blood Vessel Development Negative Regulation Of Transcription, DNA-templated Vasculature Development Hypothalamus Development Negative Regulation Of Nucleic Acid-templated Transcription Limb Morphogenesis Negative Regulation Of RNA Biosynthetic Process Trachea Development Limb Development Sensory Organ Development Response To Estrogen Interaction With Symbiont Positive Regulation Of Epithelial To Mesenchymal Transition Embryonic Morphogenesis Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process	Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Embryo Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Pattern Specification Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Epidermis Development Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of DNA Binding Regulation Of Protein Import Into Nucleus Regulation Of Transcription Factor Import Into Nucleus Regulation Of Signaling Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Protein Localization To Nucleus Developmental Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Signal Transduction Biosynthetic Process RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Binding Keratinization Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Epidermal Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Phospholipid Scrambling Regulation Of Intracellular Protein Transport Gene Expression Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Blood Coagulation
Tagcloud ?		creation demonstration descend ectopic ehbs enabling endow ephemeral erythrocytes expandable facilitates gata2 give harnessed hemangioblast hemangioblasts leukocytes lineages lmo2 mesodermal multilineage mycn progenitor progenitors rise serves sox17 tal1 tractable	divergence embryo embryos exert gsc illustrate introduced liganded ligands malformations microinjection nevertheless pleiotropic possess posterior rar reporter responsive responsiveness retinoid retinoids rxr selective striking vertebrate vertebrates xenopus xlim zebrafish
Tagcloud (Difference) ?		creation demonstration descend ectopic ehbs enabling endow ephemeral erythrocytes expandable facilitates gata2 give harnessed hemangioblast hemangioblasts leukocytes lineages lmo2 mesodermal multilineage mycn progenitor progenitors rise serves sox17 tal1 tractable	divergence embryo embryos exert gsc illustrate introduced liganded ligands malformations microinjection nevertheless pleiotropic possess posterior rar reporter responsive responsiveness retinoid retinoids rxr selective striking vertebrate vertebrates xenopus xlim zebrafish
Tagcloud (Intersection) ?