PITX2 and HOXA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PITX2	HOXA1
Description		paired like homeodomain 2	homeobox A1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Sequence-specific DNA Binding Phosphoprotein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Vasculogenesis In Utero Embryonic Development Neuron Migration Extraocular Skeletal Muscle Development Outflow Tract Morphogenesis Atrioventricular Valve Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Pulmonary Myocardium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Heart Development Skeletal Muscle Tissue Development Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Animal Organ Morphogenesis Wnt Signaling Pathway Subthalamic Nucleus Development Hypothalamus Cell Migration Pituitary Gland Development Lung Development Regulation Of Cell Migration Embryonic Camera-type Eye Development Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Vascular Associated Smooth Muscle Cell Differentiation Deltoid Tuberosity Development Regulation Of Cell Population Proliferation Odontogenesis Camera-type Eye Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Embryonic Digestive Tract Morphogenesis System Development Cardiac Muscle Tissue Development Cardiac Muscle Cell Differentiation Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Digestive System Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Ventricular Septum Morphogenesis Left Lung Morphogenesis Pulmonary Vein Morphogenesis Superior Vena Cava Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Endodermal Digestive Tract Morphogenesis Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Sensory Perception Of Sound Optokinetic Behavior Anatomical Structure Morphogenesis Abducens Nerve Formation Outer Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Neurocranium Morphogenesis Inner Ear Development Artery Morphogenesis Regulation Of Behavior Cognition Neuromuscular Process Artery Development Semicircular Canal Formation Cochlea Development Cochlea Morphogenesis
Pathways		TFAP2 (AP-2) family regulates transcription of other transcription factors	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases		Axenfeld-Rieger syndrome (ARS)	Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome
GWAS		Appendectomy ( 30392061) Atrial fibrillation ( 19597492 33990960 30061737 29892015 29290336 28416822 28416818 20173747 22544366) Atrial fibrillation/atrial flutter ( 17603472) Cardioembolic stroke (CCS and TOAST classification) ( 32047268) Cardioembolic stroke (CCS or TOAST classification) ( 32047268) Cardioembolic stroke (CCSc classification) ( 32047268) Cardioembolic stroke (CCSp classification) ( 32047268) Cardioembolic stroke (TOAST classification) ( 32047268) Cognitive decline rate in late mild cognitive impairment ( 26252872) Early onset atrial fibrillation ( 28460022) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma (primary open-angle) ( 33627673) Heart failure ( 31919418) Incident atrial fibrillation ( 28416818) Intraocular pressure ( 29235454) Ischemic stroke ( 24262325 26708676) Ischemic stroke (cardioembolic) ( 26708676 27068588) Lung cancer ( 28604730) Prevalent atrial fibrillation ( 28416818) Sick sinus syndrome ( 33580673) Smoking status (heavy vs never) ( 26423011) Stroke (ischemic) ( 23041239)	Chronic venous disease ( 28374850) Macular thickness ( 30535121) Multiple sclerosis ( 31604244) Small cell lung carcinoma ( 28604730) Tonsillectomy ( 27182965 28928442)
Interacting Genes		36 interacting genes: ATN1 CTNNB1 CYSRT1 DAZAP2 DYNLT1 HDAC1 HERC5 HEY1 HOXA1 KAT5 KRT34 KRTAP15-1 KRTAP19-5 KRTAP19-7 KRTAP3-3 KRTAP6-1 KRTAP7-1 LEF1 OIP5 PDLIM1 PFDN5 POU2AF1 PROP1 PSMB4 RBPMS SPMIP9 TINAGL1 TLE5 TRAF1 TRIB3 TRIM25 UFSP1 VGLL3 WWOX ZNF34 ZNHIT3	344 interacting genes: ACOT7 ADAM12 ADAMTSL2 ADAMTSL4 AGAP3 AGRN AGXT ALG13 ALPP AMMECR1 AMOT ANKS1A ARID5A ARMC7 ATG9B ATP23 ATXN2L BAG4 BAHD1 BATF2 BEND5 BLCAP BLZF1 BSCL2 BSDC1 BUD31 C11orf16 CATSPER1 CCDC120 CCDC33 CCN3 CCN4 CCN5 CCNK CD163 CD164 CDPF1 CERCAM CFAP68 CFP CHIC2 CHRD CHRDL2 CIRSR CNFN CNNM3 COL8A1 CREB5 CRELD1 CRELD2 CUTA CXCL16 CYP21A2 CYSRT1 DBF4B DCTN1 DGKQ DKK3 DOCK2 DOCK3 DOK3 DRC4 DTX2 DUSP10 DUSP22 EEF1A1 EFEMP1 EFEMP2 EGFL7 ENKD1 EPDR1 ESM1 ESR2 EVA1B FAAP100 FAM219B FAM221A FBLN1 FBLN2 FBLN5 FBN1 FHL3 FHL5 FN1 FOXH1 FOXN1 FRS3 FST FUCA2 GATA1 GCM2 GDF15 GNE GP9 GPRASP3 GPS2 GRN GSTP1 GUCD1 HEXB HEXIM2 HEY2 HOXB9 HR HSD3B7 ID3 IGFL1 IGFN1 INCA1 INO80B IRX6 ITGB4 JAG2 KCTD9 KDM1A KPRP KRT31 KRT33B KRT34 KRT35 KRT37 KRT38 KRT40 KRT81 KRT82 KRT83 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP15-1 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP23-1 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LAMA5 LAMB2 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LGALS13 LGALS4 LIMS2 LMX1B LNX1 LONRF1 LPXN LTBP1 LTBP3 LTBP4 LUC7L2 MACO1 MAPKBP1 MDFI MEGF6 MEGF8 MFAP2 MGAT5B MKRN3 MLLT11 MYO15B MYPOP N4BP2L2 NBPF19 NCK2 NECTIN2 NEDD9 NEK6 NELL1 NELL2 NFKBID NOTCH1 NOTCH2NLA NOTCH3 NR1D2 NTN4 NUCB1 NXF1 ODF1 OIT3 OPLAH OTX1 P2RY6 PAX6 PBX2 PCSK5 PCYOX1 PCYT2 PHETA1 PIK3R1 PIN1 PITX1 PITX2 PKM PKNOX1 PLA2G10 PLEKHN1 PLLP PLSCR1 PLSCR2 PLSCR3 PLSCR4 PRICKLE4 PRMT6 PROP1 PSMB1 PTH1R PVR PYCR3 QARS1 R3HDM1 RALGDS RANBP3 RBCK1 RBP3 RBPMS RCHY1 RGS17 RGS19 RGS20 RNF208 RSPO2 RTN4R SAXO4 SCT SDCBP SIVA1 SLC15A3 SLC23A1 SLIT1 SLIT2 SLPI SMCP SND1 SNRPB SNRPC SPATA12 SPATA18 SPRY1 SPRY2 SPRY3 SPRY4 SSC4D SSUH2 STX11 SUV39H1 TBC1D10C TBR1 TBX15 TCF19 TCF3 TEKT4 TEKT5 TGFB1 TGFB1I1 TGM7 THAP7 TLE5 TNS2 TRAF1 TRAF2 TRAF4 TRAPPC6A TRIM42 TRIM55 TRIM63 TRIM8 TRIP6 TSPAN4 UBL5 UNKL VASN VWC2 VWC2L VWCE VWF WDR83 WWOX YIPF3 YPEL3 ZBTB16 ZFTRAF1 ZIM2 ZMAT1 ZNF417 ZNF587 ZNF688 ZNF774 ZNF837 ZNF843 ZNRF3
Entrez ID		5308	3198
HPRD ID		03328	00843
Ensembl ID		ENSG00000164093	ENSG00000105991
Uniprot IDs		Q99697	E7ERT8 P49639
PDB IDs		2L7F 2L7M 2LKX
Enriched GO Terms of Interacting Partners?		Transcription Coactivator Activity Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Regulator Complex Fungiform Papilla Formation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Hair Follicle Placode Formation Regulation Of Wnt Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Odontoblast Differentiation Positive Regulation Of Neuroepithelial Cell Differentiation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Odontoblast Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Beta-catenin-TCF Complex Maintenance Of Cell Polarity Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Epithelial To Mesenchymal Transition Positive Regulation Of Biosynthetic Process Regulation Of Neurogenesis Positive Regulation Of Transcription By RNA Polymerase II Cytoplasmic Stress Granule Negative Regulation Of Nucleobase-containing Compound Metabolic Process Odontogenesis Positive Regulation Of Macromolecule Metabolic Process Protein Binding Mesenchymal Cell Differentiation Host-mediated Perturbation Of Symbiont Process	Intermediate Filament Keratin Filament Keratinization Protein Binding Epidermis Development Extracellular Matrix Hair Cycle Extracellular Matrix Structural Constituent Structural Constituent Of Skin Epidermis Tissue Development Integrin Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Calcium Ion Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Intermediate Filament Organization Basement Membrane Microfibril Identical Protein Binding Regulation Of Cellular Response To Growth Factor Stimulus Developmental Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Animal Organ Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Phospholipid Scramblase Activity Extracellular Region Morphogenesis Of An Epithelium Negative Regulation Of Cellular Response To Growth Factor Stimulus Plasma Membrane Phospholipid Scrambling Anatomical Structure Morphogenesis Elastic Fiber Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Structural Molecule Activity Tissue Morphogenesis Heparin Binding Roundabout Binding Embryonic Morphogenesis Extracellular Space Negative Regulation Of Biomineral Tissue Development Embryonic Hindlimb Morphogenesis Post-embryonic Eye Morphogenesis Extracellular Matrix Assembly Cell Fate Commitment TRAF2-GSTP1 Complex Vasculogenesis Lead Ion Binding Susceptibility To T Cell Mediated Cytotoxicity Lung Growth Regionalization Skeletal System Development
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