PITX2 and PROP1

Number of citations of the paper that reports this interaction (PMID 9685346)
35

Data Source:
HPRD (in vitro)

		PITX2	PROP1
Gene Name		paired-like homeodomain 2	PROP paired-like homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleus Transcription Factor Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Phosphoprotein Binding	Chromatin Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Patterning Of Blood Vessels Vasculogenesis In Utero Embryonic Development Neuron Migration Extraocular Skeletal Muscle Development Atrioventricular Valve Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Pulmonary Myocardium Development Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Determination Of Left/right Symmetry Myoblast Fusion Male Gonad Development Female Gonad Development Response To Hormone Wnt Signaling Pathway Subthalamic Nucleus Development Hypothalamus Cell Migration Regulation Of Cell Migration Embryonic Camera-type Eye Development Response To Vitamin A Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Vascular Smooth Muscle Cell Differentiation Deltoid Tuberosity Development Odontogenesis Of Dentin-containing Tooth Odontogenesis Camera-type Eye Development Positive Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Embryonic Digestive Tract Morphogenesis Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Ventricular Septum Morphogenesis Left Lung Morphogenesis Pulmonary Vein Morphogenesis Superior Vena Cava Morphogenesis Endodermal Digestive Tract Morphogenesis Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification Positive Regulation Of Myoblast Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Central Nervous System Development Dorsal/ventral Pattern Formation Cell Migration Hypothalamus Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Hypophysis Morphogenesis Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 20173747 19597492 22544366) Atrial fibrillation/atrial flutter ( 17603472) Stroke (ischemic) ( 23041239)
Protein-Protein Interactions		10 interactors: CTNNB1 HDAC1 HERC5 HOXA1 KAT5 LEF1 PDLIM1 PROP1 TRIM25 ZNHIT3	2 interactors: HESX1 PITX2
Entrez ID		5308	5626
HPRD ID		03328	03325
Ensembl ID		ENSG00000164093	ENSG00000175325
Uniprot IDs		Q99697	O75360
PDB IDs		2L7F 2L7M 2LKX
Enriched GO Terms of Interacting Partners?		Tongue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cytokine Production Regulation Of Cytokine Production Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Fungiform Papilla Formation Regulation Of Nitrogen Compound Metabolic Process Canonical Wnt Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Fungiform Papilla Morphogenesis Odontogenesis Of Dentin-containing Tooth Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Type I Interferon Production Fungiform Papilla Development Response To Lipid Positive Regulation Of Gene Expression Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Hair Follicle Placode Formation Odontogenesis Tongue Morphogenesis Organ Morphogenesis Response To Steroid Hormone Pattern Specification Process Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Limb Morphogenesis Blood Vessel Development Negative Regulation Of Transcription, DNA-templated Vasculature Development Hypothalamus Development Negative Regulation Of Nucleic Acid-templated Transcription Limb Morphogenesis Negative Regulation Of RNA Biosynthetic Process Trachea Development Limb Development Sensory Organ Development Response To Estrogen Interaction With Symbiont Positive Regulation Of Epithelial To Mesenchymal Transition Embryonic Morphogenesis Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process	Subthalamic Nucleus Development Prolactin Secreting Cell Differentiation Superior Vena Cava Morphogenesis Respiratory System Development Cell Proliferation Involved In Outflow Tract Morphogenesis Left Lung Morphogenesis Pulmonary Vein Morphogenesis Subthalamus Development Embryonic Organ Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Extraocular Skeletal Muscle Development Left Lung Development Pulmonary Myocardium Development Endodermal Digestive Tract Morphogenesis Forebrain Development Deltoid Tuberosity Development Somatotropin Secreting Cell Differentiation Embryonic Organ Development Positive Regulation Of Myoblast Proliferation Morphogenesis Of An Epithelium Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Hypothalamus Cell Migration Regulation Of Myoblast Proliferation Sensory Organ Development Atrial Cardiac Muscle Tissue Morphogenesis Iris Morphogenesis Embryonic Morphogenesis Tissue Morphogenesis Otic Vesicle Formation Venous Blood Vessel Morphogenesis Otic Vesicle Morphogenesis Brain Development Adenohypophysis Development Left/right Axis Specification Head Development Otic Vesicle Development Venous Blood Vessel Development Vascular Smooth Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Development Nose Development Central Nervous System Development Forebrain Morphogenesis Myoblast Fusion Organ Morphogenesis Left/right Pattern Formation Atrioventricular Valve Development Anatomical Structure Formation Involved In Morphogenesis Hypothalamus Development Epithelium Development Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		creation demonstration descend ectopic ehbs enabling endow ephemeral erythrocytes expandable facilitates gata2 give harnessed hemangioblast hemangioblasts leukocytes lineages lmo2 mesodermal multilineage mycn progenitor progenitors rise serves sox17 tal1 tractable	abundant anterior bait cdna cloned cloning diencephalon differentiating fshbeta gland homeobox hybrid library lobe participating periods pituitary porcine pou primordium progenitor prrx1 prrx2 retina rpf1 sequence transcripts upstream yeast
Tagcloud (Difference) ?		creation demonstration descend ectopic ehbs enabling endow ephemeral erythrocytes expandable facilitates gata2 give harnessed hemangioblast hemangioblasts leukocytes lineages lmo2 mesodermal multilineage mycn progenitors rise serves sox17 tal1 tractable	abundant anterior bait cdna cloned cloning diencephalon differentiating fshbeta gland homeobox hybrid library lobe participating periods pituitary porcine pou primordium prrx1 prrx2 retina rpf1 sequence transcripts upstream yeast
Tagcloud (Intersection) ?		progenitor