PITX2 and HDAC1

Number of citations of the paper that reports this interaction (PMID 12464179)
130

Data Source:
HPRD (in vivo)

		PITX2	HDAC1
Gene Name		paired-like homeodomain 2	histone deacetylase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Histone Deacetylase Complex Chromatin Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Sin3 Complex NuRD Complex Protein Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Phosphoprotein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Corepressor Activity Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Deacetylase Activity Enzyme Binding Nucleosomal DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Protein N-terminus Binding Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Patterning Of Blood Vessels Vasculogenesis In Utero Embryonic Development Neuron Migration Extraocular Skeletal Muscle Development Atrioventricular Valve Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Pulmonary Myocardium Development Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Determination Of Left/right Symmetry Myoblast Fusion Male Gonad Development Female Gonad Development Response To Hormone Wnt Signaling Pathway Subthalamic Nucleus Development Hypothalamus Cell Migration Regulation Of Cell Migration Embryonic Camera-type Eye Development Response To Vitamin A Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Vascular Smooth Muscle Cell Differentiation Deltoid Tuberosity Development Odontogenesis Of Dentin-containing Tooth Odontogenesis Camera-type Eye Development Positive Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Embryonic Digestive Tract Morphogenesis Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Ventricular Septum Morphogenesis Left Lung Morphogenesis Pulmonary Vein Morphogenesis Superior Vena Cava Morphogenesis Endodermal Digestive Tract Morphogenesis Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification Positive Regulation Of Myoblast Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Deacetylation Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Blood Coagulation Positive Regulation Of Cell Proliferation Epidermal Cell Differentiation Gene Expression Negative Regulation Of Myotube Differentiation Positive Regulation Of Receptor Biosynthetic Process Viral Process Chromatin Modification Histone Deacetylation Circadian Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis ATP-dependent Chromatin Remodeling Negative Regulation Of Apoptotic Process Negative Regulation By Host Of Viral Transcription Negative Regulation Of Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Hair Follicle Placode Formation Eyelid Development In Camera-type Eye Fungiform Papilla Formation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation
Pathways			Loss of Function of TGFBR2 in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated SMAD2/3 MH2 Domain Mutants in Cancer TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Degradation of beta-catenin by the destruction complex NoRC negatively regulates rRNA expression Generic Transcription Pathway S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 in Cancer Mitotic G1-G1/S phases truncations of AMER1 destabilize the destruction complex TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated TGFBR1 KD Mutants in Cancer Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation APC truncation mutants have impaired AXIN binding RNA Polymerase I Promoter Clearance TGFBR1 LBD Mutants in Cancer deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF HDACs deacetylate histones p75NTR negatively regulates cell cycle via SC1 Loss of Function of SMAD2/3 in Cancer RNA Polymerase I Transcription TGFBR2 Kinase Domain Mutants in Cancer Epigenetic regulation of gene expression p75 NTR receptor-mediated signalling G0 and Early G1 Negative epigenetic regulation of rRNA expression repression of WNT target genes Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Atrial fibrillation ( 20173747 19597492 22544366) Atrial fibrillation/atrial flutter ( 17603472) Stroke (ischemic) ( 23041239)
Protein-Protein Interactions		10 interactors: CTNNB1 HDAC1 HERC5 HOXA1 KAT5 LEF1 PDLIM1 PROP1 TRIM25 ZNHIT3	193 interactors: APEX1 APPL1 AR ARHGAP35 ARID4A ATF3 ATRX BAZ2A BCL3 BCL6B BCOR BHLHE40 BRCA1 BRMS1 BRMS1L BUB1 BUB1B BUB3 CBFA2T3 CDC20 CDH1 CDKN1A CDYL CHD1 CHD4 CHFR CIITA CNTN2 CREBBP CREM CSNK2A1 CSNK2A2 CTBP1 DAXX DDB2 DDX17 DHX30 DNMT1 DNMT3A DNMT3B DNMT3L EED EID2 EID2B ELK1 ENO1 EP300 EZH2 FKBP3 FOXG1 FRA10F GATAD2A GATAD2B GCM1 GMNN GPS2 HBP1 HDAC2 HDAC3 HDAC7 HDAC9 HELLS HEY2 HIC1 HIF1A HIF1AN HIST1H4A HIST3H3 HNRNPD HR HUS1 IKZF1 ING1 IRF5 JDP2 KAT5 KCTD11 KDM1A KLF1 KLF11 KLF4 KLF5 LCOR LINC00152 MAD1L1 MAGEA1 MBD2 MBD3 MBD3L2 MBD4 MCM6 MDM2 MECOM MECP2 MEN1 MIER1 MORF4L2 MTA1 MXD1 MYOD1 NCOR2 NFE4 NFKB1 NFKBIA NKX2-5 NKX3-2 NR1D2 NR2E3 NR2F2 NRIP1 NUP98 PARP1 PCNA PEX14 PHB PHB2 PHF12 PHF21A PIAS3 PIAS4 PIK3R1 PITX2 PLK4 PML PPARD PPARG PPP2R1B PRKACA PRKG1 PRRG4 PTMA RAD9A RAP1A RARA RB1 RBBP4 RBBP7 RBL1 RBL2 RBP1 RBPJ RELA REPIN1 RFC1 RFC4 RICTOR RUNX1 RUNX1T1 RUNX3 RUVBL1 RUVBL2 SALL1 SAP18 SAP30 SATB1 SATB2 SENP1 SET SETDB1 SIN3A SIN3B SMAD2 SMAD3 SOX6 SP1 SP3 SPEN SPI1 STAT2 STAT3 SUDS3 SUV39H1 SYK TAB2 TAL1 TFCP2 TGIF1 TGIF2 THAP11 TOP2A TOP2B TP53 TPD52L1 TRIM27 TXNIP UBE2I UHRF2 VHL VPRBP WISP2 ZBTB16 ZMYND11 ZNF76
Entrez ID		5308	3065
HPRD ID		03328	03143
Ensembl ID		ENSG00000164093	ENSG00000116478
Uniprot IDs		Q99697	Q13547 Q6IT96
PDB IDs		2L7F 2L7M 2LKX	1TYI 4BKX
Enriched GO Terms of Interacting Partners?		Tongue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cytokine Production Regulation Of Cytokine Production Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Fungiform Papilla Formation Regulation Of Nitrogen Compound Metabolic Process Canonical Wnt Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Fungiform Papilla Morphogenesis Odontogenesis Of Dentin-containing Tooth Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Type I Interferon Production Fungiform Papilla Development Response To Lipid Positive Regulation Of Gene Expression Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Hair Follicle Placode Formation Odontogenesis Tongue Morphogenesis Organ Morphogenesis Response To Steroid Hormone Pattern Specification Process Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Limb Morphogenesis Blood Vessel Development Negative Regulation Of Transcription, DNA-templated Vasculature Development Hypothalamus Development Negative Regulation Of Nucleic Acid-templated Transcription Limb Morphogenesis Negative Regulation Of RNA Biosynthetic Process Trachea Development Limb Development Sensory Organ Development Response To Estrogen Interaction With Symbiont Positive Regulation Of Epithelial To Mesenchymal Transition Embryonic Morphogenesis Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process	Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Chromosome Organization Chromatin Organization Cellular Metabolic Process Chromatin Modification Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Organelle Organization Regulation Of Gene Expression, Epigenetic Metabolic Process Histone Modification Negative Regulation Of Gene Expression, Epigenetic Organ Development Developmental Process Cell Differentiation Cell Cycle Multicellular Organismal Development
Tagcloud ?		creation demonstration descend ectopic ehbs enabling endow ephemeral erythrocytes expandable facilitates gata2 give harnessed hemangioblast hemangioblasts leukocytes lineages lmo2 mesodermal multilineage mycn progenitor progenitors rise serves sox17 tal1 tractable	bhlh complexes corepressors deacetylase deacetylation heterodimerize heterodimers heterogeneous immunocomplexes mad max mediates members msin3a msin3b multimeric multiprotein p50 p55 polypeptides possess reporter repress repression ternary tightly transcriptional trapoxin zip
Tagcloud (Difference) ?		creation demonstration descend ectopic ehbs enabling endow ephemeral erythrocytes expandable facilitates gata2 give harnessed hemangioblast hemangioblasts leukocytes lineages lmo2 mesodermal multilineage mycn progenitor progenitors rise serves sox17 tal1 tractable	bhlh complexes corepressors deacetylase deacetylation heterodimerize heterodimers heterogeneous immunocomplexes mad max mediates members msin3a msin3b multimeric multiprotein p50 p55 polypeptides possess reporter repress repression ternary tightly transcriptional trapoxin zip
Tagcloud (Intersection) ?