PITX2 and ZNHIT3

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		PITX2	ZNHIT3
Gene Name		paired-like homeodomain 2	zinc finger, HIT-type containing 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Intracellular
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Phosphoprotein Binding	Metal Ion Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Patterning Of Blood Vessels Vasculogenesis In Utero Embryonic Development Neuron Migration Extraocular Skeletal Muscle Development Atrioventricular Valve Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Pulmonary Myocardium Development Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Determination Of Left/right Symmetry Myoblast Fusion Male Gonad Development Female Gonad Development Response To Hormone Wnt Signaling Pathway Subthalamic Nucleus Development Hypothalamus Cell Migration Regulation Of Cell Migration Embryonic Camera-type Eye Development Response To Vitamin A Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Vascular Smooth Muscle Cell Differentiation Deltoid Tuberosity Development Odontogenesis Of Dentin-containing Tooth Odontogenesis Camera-type Eye Development Positive Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Embryonic Digestive Tract Morphogenesis Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Ventricular Septum Morphogenesis Left Lung Morphogenesis Pulmonary Vein Morphogenesis Superior Vena Cava Morphogenesis Endodermal Digestive Tract Morphogenesis Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification Positive Regulation Of Myoblast Proliferation	Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 20173747 19597492 22544366) Atrial fibrillation/atrial flutter ( 17603472) Stroke (ischemic) ( 23041239)
Protein-Protein Interactions		10 interactors: CTNNB1 HDAC1 HERC5 HOXA1 KAT5 LEF1 PDLIM1 PROP1 TRIM25 ZNHIT3	13 interactors: CSNK2A2 ESR2 FAIM3 HNF4A MBNL1 MEIS2 PBX3 PITX2 PPARG RXRA THRB XRCC3 ZNF24
Entrez ID		5308	9326
HPRD ID		03328	05139
Ensembl ID		ENSG00000164093	ENSG00000108278
Uniprot IDs		Q99697	K7EQP1 Q15649
PDB IDs		2L7F 2L7M 2LKX	2YQQ
Enriched GO Terms of Interacting Partners?		Tongue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cytokine Production Regulation Of Cytokine Production Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Fungiform Papilla Formation Regulation Of Nitrogen Compound Metabolic Process Canonical Wnt Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Fungiform Papilla Morphogenesis Odontogenesis Of Dentin-containing Tooth Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Type I Interferon Production Fungiform Papilla Development Response To Lipid Positive Regulation Of Gene Expression Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Hair Follicle Placode Formation Odontogenesis Tongue Morphogenesis Organ Morphogenesis Response To Steroid Hormone Pattern Specification Process Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Limb Morphogenesis Blood Vessel Development Negative Regulation Of Transcription, DNA-templated Vasculature Development Hypothalamus Development Negative Regulation Of Nucleic Acid-templated Transcription Limb Morphogenesis Negative Regulation Of RNA Biosynthetic Process Trachea Development Limb Development Sensory Organ Development Response To Estrogen Interaction With Symbiont Positive Regulation Of Epithelial To Mesenchymal Transition Embryonic Morphogenesis Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process	Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Transcription, DNA-templated RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Nucleobase-containing Compound Metabolic Process Gene Expression Intracellular Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process System Development Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Multicellular Organismal Development Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Lipid Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Lipid Negative Regulation Of Cellular Metabolic Process Response To Steroid Hormone Organ Development Peroxisome Proliferator Activated Receptor Signaling Pathway Developmental Process Response To Hormone Regulation Of Transcription, DNA-templated Epithelial Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Developmental Process Involved In Reproduction Reproductive Process
Tagcloud ?		creation demonstration descend ectopic ehbs enabling endow ephemeral erythrocytes expandable facilitates gata2 give harnessed hemangioblast hemangioblasts leukocytes lineages lmo2 mesodermal multilineage mycn progenitor progenitors rise serves sox17 tal1 tractable	5k adenosine applies assembly bcd1 box core existence gets hsp90 isotope nop58 nucleolar nufip premature proteomic r2tp ribonucleoproteins rsa1p ruvbl scheme sequential snornas snornp snornps snu13p triphosphatase unexpected unload
Tagcloud (Difference) ?		creation demonstration descend ectopic ehbs enabling endow ephemeral erythrocytes expandable facilitates gata2 give harnessed hemangioblast hemangioblasts leukocytes lineages lmo2 mesodermal multilineage mycn progenitor progenitors rise serves sox17 tal1 tractable	5k adenosine applies assembly bcd1 box core existence gets hsp90 isotope nop58 nucleolar nufip premature proteomic r2tp ribonucleoproteins rsa1p ruvbl scheme sequential snornas snornp snornps snu13p triphosphatase unexpected unload
Tagcloud (Intersection) ?