PITX2 and HERC5

Number of citations of the paper that reports this interaction (PMID 16884686)
17

Data Source:
BioGRID (pull down)

		PITX2	HERC5
Gene Name		paired-like homeodomain 2	HECT and RLD domain containing E3 ubiquitin protein ligase 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Phosphoprotein Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity ISG15 Transferase Activity Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Patterning Of Blood Vessels Vasculogenesis In Utero Embryonic Development Neuron Migration Extraocular Skeletal Muscle Development Atrioventricular Valve Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Pulmonary Myocardium Development Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Determination Of Left/right Symmetry Myoblast Fusion Male Gonad Development Female Gonad Development Response To Hormone Wnt Signaling Pathway Subthalamic Nucleus Development Hypothalamus Cell Migration Regulation Of Cell Migration Embryonic Camera-type Eye Development Response To Vitamin A Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Vascular Smooth Muscle Cell Differentiation Deltoid Tuberosity Development Odontogenesis Of Dentin-containing Tooth Odontogenesis Camera-type Eye Development Positive Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Embryonic Digestive Tract Morphogenesis Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Ventricular Septum Morphogenesis Left Lung Morphogenesis Pulmonary Vein Morphogenesis Superior Vena Cava Morphogenesis Endodermal Digestive Tract Morphogenesis Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification Positive Regulation Of Myoblast Proliferation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cytokine-mediated Signaling Pathway ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Virus
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Innate Immune System
Drugs
Diseases
GWAS		Atrial fibrillation ( 20173747 19597492 22544366) Atrial fibrillation/atrial flutter ( 17603472) Stroke (ischemic) ( 23041239)	Pulmonary function decline ( 22424883)
Protein-Protein Interactions		10 interactors: CTNNB1 HDAC1 HERC5 HOXA1 KAT5 LEF1 PDLIM1 PROP1 TRIM25 ZNHIT3	10 interactors: CCNA2 CCNB1 CCND1 CCNE1 CDKN1A ERCC2 NME2 PITX2 STK38 UBE2D1
Entrez ID		5308	51191
HPRD ID		03328	10502
Ensembl ID		ENSG00000164093	ENSG00000138646
Uniprot IDs		Q99697	B4DXV3 E9PBL0 Q9UII4
PDB IDs		2L7F 2L7M 2LKX
Enriched GO Terms of Interacting Partners?		Tongue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cytokine Production Regulation Of Cytokine Production Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Fungiform Papilla Formation Regulation Of Nitrogen Compound Metabolic Process Canonical Wnt Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Fungiform Papilla Morphogenesis Odontogenesis Of Dentin-containing Tooth Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Type I Interferon Production Fungiform Papilla Development Response To Lipid Positive Regulation Of Gene Expression Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Hair Follicle Placode Formation Odontogenesis Tongue Morphogenesis Organ Morphogenesis Response To Steroid Hormone Pattern Specification Process Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Limb Morphogenesis Blood Vessel Development Negative Regulation Of Transcription, DNA-templated Vasculature Development Hypothalamus Development Negative Regulation Of Nucleic Acid-templated Transcription Limb Morphogenesis Negative Regulation Of RNA Biosynthetic Process Trachea Development Limb Development Sensory Organ Development Response To Estrogen Interaction With Symbiont Positive Regulation Of Epithelial To Mesenchymal Transition Embryonic Morphogenesis Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process	Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Process Regulation Of Protein Kinase Activity Negative Regulation Of Gene Expression Protein Phosphorylation Mitotic Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation G1/S Transition Of Mitotic Cell Cycle Response To Lipid Cell Division Mitotic Cell Cycle Checkpoint Cell Cycle Process Regulation Of Protein Phosphorylation Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Phosphorylation Positive Regulation Of Fibroblast Proliferation Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Organ Regeneration Cellular Protein Modification Process Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Cell Cycle Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Mitotic DNA Damage Checkpoint Regulation Of Fibroblast Proliferation Mitotic DNA Integrity Checkpoint Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Gene Expression Response To Organic Substance G2/M Transition Of Mitotic Cell Cycle Response To Organic Cyclic Compound Response To UV Response To Hormone
Tagcloud ?		creation demonstration descend ectopic ehbs enabling endow ephemeral erythrocytes expandable facilitates gata2 give harnessed hemangioblast hemangioblasts leukocytes lineages lmo2 mesodermal multilineage mycn progenitor progenitors rise serves sox17 tal1 tractable	accumulation alternative attractive deletion drugs enhancing inactivation involving isg15 isgylation multistep native oncogene oncogenes p53 promoting propose regulate src stability suppressing suppressor suppressors transformation transformed tumorigenesis turn tyr126 tyr220
Tagcloud (Difference) ?		creation demonstration descend ectopic ehbs enabling endow ephemeral erythrocytes expandable facilitates gata2 give harnessed hemangioblast hemangioblasts leukocytes lineages lmo2 mesodermal multilineage mycn progenitor progenitors rise serves sox17 tal1 tractable	accumulation alternative attractive deletion drugs enhancing inactivation involving isg15 isgylation multistep native oncogene oncogenes p53 promoting propose regulate src stability suppressing suppressor suppressors transformation transformed tumorigenesis turn tyr126 tyr220
Tagcloud (Intersection) ?