HOXA1 and SUV39H1

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		HOXA1	SUV39H1
Gene Name		homeobox A1	suppressor of variegation 3-9 homolog 1 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex RDNA Heterochromatin
	Molecular Function	Protein Binding Sequence-specific DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Protein N-terminus Binding
	Biological Process	Transcription, DNA-templated Multicellular Organismal Development Sensory Perception Of Sound Optokinetic Behavior Motor Neuron Axon Guidance Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Rhombomere 3 Development Rhombomere 4 Development Rhombomere 5 Development Abducens Nerve Formation Facial Nerve Structural Organization Facial Nucleus Development Central Nervous System Neuron Differentiation Outer Ear Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Neurocranium Morphogenesis Inner Ear Development Artery Morphogenesis Regulation Of Behavior Cognition Neuromuscular Process Artery Development Semicircular Canal Formation Cellular Response To Retinoic Acid Cochlea Development Cochlea Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Chromatin Organization Transcription, DNA-templated RRNA Processing Cellular Response To DNA Damage Stimulus Cell Cycle Gene Expression Viral Process Cell Differentiation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Circadian Rhythm Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways			Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression SIRT1 negatively regulates rRNA Expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		79 interactors: ABHD17A ADAMTSL4 ALG13 BLZF1 C1orf94 CCDC33 CHIC2 CHRD CRACR2A DUSP22 EFEMP2 FAM154A FHL5 GATA1 GP9 GRN HOXD3 HSFY1 IKZF2 KDM1A KRT31 KRT38 KRT40 KRT81 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE3E LCE4A LGALS13 LIMS1 LNX2 LPXN MDFI MGAT5B N4BP2L2 NOTCH2NL PBX1 PBX2 PCSK5 PDCD6IP PIK3R1 PITX2 PKNOX1 PLSCR1 PLSCR4 PRMT6 PRRC2B RAB33A RBPMS RGS17 RGS20 SDCBP SPRY1 SUV39H1 TBC1D10C TCF3 TRAF1 TRAPPC6A TRIM42 TRIP6 ZZZ3	123 interactors: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C17orf82 C4orf17 C8orf74 CBX1 CBX4 CBX5 CCDC151 CCDC37 CDC23 CDCA4 CDCA7L CEP70 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DNMT1 DNMT3A DNMT3B ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GPATCH2L GTF2H2C_2 GTPBP2 H3F3C HDAC1 HDAC2 HDAC3 HDAC5 HDAC9 HIST1H3A HIST2H3A HIST3H3 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRTAP10-7 LDHAL6B LENG8 LHX8 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 OPA3 PHF19 PML PNKP PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEX35 THRA TMEM11 TNFAIP1 U2AF1 WDFY3 WIZ ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF436 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZSCAN9
Entrez ID		3198	6839
HPRD ID		00843	02221
Ensembl ID		ENSG00000105991	ENSG00000101945
Uniprot IDs		P49639	B4DST0 O43463
PDB IDs			3MTS
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Embryo Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Pattern Specification Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Epidermis Development Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of DNA Binding Regulation Of Protein Import Into Nucleus Regulation Of Transcription Factor Import Into Nucleus Regulation Of Signaling Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Protein Localization To Nucleus Developmental Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Signal Transduction Biosynthetic Process RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Binding Keratinization Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Epidermal Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Phospholipid Scrambling Regulation Of Intracellular Protein Transport Gene Expression Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Blood Coagulation	RNA Biosynthetic Process Transcription, DNA-templated Gene Expression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Chromatin Modification Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromosome Organization Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression, Epigenetic Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Organelle Organization Chromatin Silencing Gene Silencing Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation On Cytosine Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Histone Modification Histone H4 Deacetylation Cellular Process Regulation Of Cell Cycle Metabolic Process
Tagcloud ?		divergence embryo embryos exert gsc illustrate introduced liganded ligands malformations microinjection nevertheless pleiotropic possess posterior rar reporter responsive responsiveness retinoid retinoids rxr selective striking vertebrate vertebrates xenopus xlim zebrafish	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly setdb1 t98g verified
Tagcloud (Difference) ?		divergence embryo embryos exert gsc illustrate introduced liganded ligands malformations microinjection nevertheless pleiotropic possess posterior rar reporter responsive responsiveness retinoid retinoids rxr selective striking vertebrate vertebrates xenopus xlim zebrafish	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly setdb1 t98g verified
Tagcloud (Intersection) ?