HOXA1 and PAX6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOXA1	PAX6
Description		homeobox A1	paired box 6
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Protein Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Co-SMAD Binding R-SMAD Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Sensory Perception Of Sound Optokinetic Behavior Anatomical Structure Morphogenesis Abducens Nerve Formation Outer Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Neurocranium Morphogenesis Inner Ear Development Artery Morphogenesis Regulation Of Behavior Cognition Neuromuscular Process Artery Development Semicircular Canal Formation Cochlea Development Cochlea Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Blood Vessel Development Eye Development Cell Fate Determination Neuron Migration Positive Regulation Of Neuroblast Proliferation Lens Development In Camera-type Eye Regionalization Type B Pancreatic Cell Differentiation Pancreatic A Cell Development Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Smoothened Signaling Pathway Nervous System Development Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Axonogenesis Axon Guidance Central Nervous System Development Brain Development Sensory Organ Development Salivary Gland Morphogenesis Visual Perception Cell Population Proliferation Response To Wounding Anatomical Structure Morphogenesis Regulation Of Asymmetric Cell Division Animal Organ Morphogenesis Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Ventral Spinal Cord Development Pallium Development Oligodendrocyte Cell Fate Specification Cerebral Cortex Regionalization Forebrain Dorsal/ventral Pattern Formation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Forebrain-midbrain Boundary Formation Telencephalon Regionalization Pituitary Gland Development Habenula Development Cerebral Cortex Development Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Neuron Differentiation Keratinocyte Differentiation Regulation Of Cell Migration Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Differentiation Forebrain Development Lacrimal Gland Development Protein Localization To Organelle Eye Photoreceptor Cell Development Glucose Homeostasis Camera-type Eye Development Cell Fate Commitment Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Timing Of Cell Differentiation Embryonic Camera-type Eye Morphogenesis Neuron Fate Commitment Astrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Nervous System Process Retina Development In Camera-type Eye Iris Morphogenesis Cornea Development In Camera-type Eye Neural Precursor Cell Proliferation Positive Regulation Of MiRNA Transcription Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of the anterior neural plate
Drugs
Diseases		Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome	Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON) Aniridia Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Chronic venous disease ( 28374850) Macular thickness ( 30535121) Multiple sclerosis ( 31604244) Small cell lung carcinoma ( 28604730) Tonsillectomy ( 27182965 28928442)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Body mass index ( 22344219 28892062) Depression ( 29700475) Diastolic blood pressure ( 27841878) Feeling worry ( 29500382) General factor of neuroticism ( 30867560) Irritable mood ( 29500382) Major depressive disorder ( 27479909) Neurociticism ( 29500382) Optic disc area ( 28073927) Refractive error ( 32231278) Systolic blood pressure ( 27841878)
Interacting Genes		344 interacting genes: ACOT7 ADAM12 ADAMTSL2 ADAMTSL4 AGAP3 AGRN AGXT ALG13 ALPP AMMECR1 AMOT ANKS1A ARID5A ARMC7 ATG9B ATP23 ATXN2L BAG4 BAHD1 BATF2 BEND5 BLCAP BLZF1 BSCL2 BSDC1 BUD31 C11orf16 CATSPER1 CCDC120 CCDC33 CCN3 CCN4 CCN5 CCNK CD163 CD164 CDPF1 CERCAM CFAP68 CFP CHIC2 CHRD CHRDL2 CIRSR CNFN CNNM3 COL8A1 CREB5 CRELD1 CRELD2 CUTA CXCL16 CYP21A2 CYSRT1 DBF4B DCTN1 DGKQ DKK3 DOCK2 DOCK3 DOK3 DRC4 DTX2 DUSP10 DUSP22 EEF1A1 EFEMP1 EFEMP2 EGFL7 ENKD1 EPDR1 ESM1 ESR2 EVA1B FAAP100 FAM219B FAM221A FBLN1 FBLN2 FBLN5 FBN1 FHL3 FHL5 FN1 FOXH1 FOXN1 FRS3 FST FUCA2 GATA1 GCM2 GDF15 GNE GP9 GPRASP3 GPS2 GRN GSTP1 GUCD1 HEXB HEXIM2 HEY2 HOXB9 HR HSD3B7 ID3 IGFL1 IGFN1 INCA1 INO80B IRX6 ITGB4 JAG2 KCTD9 KDM1A KPRP KRT31 KRT33B KRT34 KRT35 KRT37 KRT38 KRT40 KRT81 KRT82 KRT83 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP15-1 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP23-1 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LAMA5 LAMB2 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LGALS13 LGALS4 LIMS2 LMX1B LNX1 LONRF1 LPXN LTBP1 LTBP3 LTBP4 LUC7L2 MACO1 MAPKBP1 MDFI MEGF6 MEGF8 MFAP2 MGAT5B MKRN3 MLLT11 MYO15B MYPOP N4BP2L2 NBPF19 NCK2 NECTIN2 NEDD9 NEK6 NELL1 NELL2 NFKBID NOTCH1 NOTCH2NLA NOTCH3 NR1D2 NTN4 NUCB1 NXF1 ODF1 OIT3 OPLAH OTX1 P2RY6 PAX6 PBX2 PCSK5 PCYOX1 PCYT2 PHETA1 PIK3R1 PIN1 PITX1 PITX2 PKM PKNOX1 PLA2G10 PLEKHN1 PLLP PLSCR1 PLSCR2 PLSCR3 PLSCR4 PRICKLE4 PRMT6 PROP1 PSMB1 PTH1R PVR PYCR3 QARS1 R3HDM1 RALGDS RANBP3 RBCK1 RBP3 RBPMS RCHY1 RGS17 RGS19 RGS20 RNF208 RSPO2 RTN4R SAXO4 SCT SDCBP SIVA1 SLC15A3 SLC23A1 SLIT1 SLIT2 SLPI SMCP SND1 SNRPB SNRPC SPATA12 SPATA18 SPRY1 SPRY2 SPRY3 SPRY4 SSC4D SSUH2 STX11 SUV39H1 TBC1D10C TBR1 TBX15 TCF19 TCF3 TEKT4 TEKT5 TGFB1 TGFB1I1 TGM7 THAP7 TLE5 TNS2 TRAF1 TRAF2 TRAF4 TRAPPC6A TRIM42 TRIM55 TRIM63 TRIM8 TRIP6 TSPAN4 UBL5 UNKL VASN VWC2 VWC2L VWCE VWF WDR83 WWOX YIPF3 YPEL3 ZBTB16 ZFTRAF1 ZIM2 ZMAT1 ZNF417 ZNF587 ZNF688 ZNF774 ZNF837 ZNF843 ZNRF3	146 interacting genes: ACOT12 AIRIM AP1M1 APP ARIH2 ATP6V0D2 ATP6V1C2 BANP BCL2L15 BTG3 CATSPERT CBR1 CBS CCDC6 CCL26 CDK3 CDX2 CFAP298 CGGBP1 CHAF1A CIB3 CINP CKS1B CSNK2A1 CTNNA3 CXorf38 DHPS DIAPH1 DLG1 DNAAF19 DSCAM DYNLL1 EAF1 EFHC1 EIF1AD EN1 EP300 ESRRG FAM50B GAS2L2 GATD3 GCM2 GEMIN2 GPANK1 GRHL2 HGS HIPK2 HMBOX1 HMGB3 HNF1B HNRNPC HOMER3 HOXA1 HOXB1 HOXC8 HOXC9 IPO13 KANK2 KCTD7 KRTAP9-3 KRTAP9-8 LARP4 LHX2 LNPK LONRF1 LXN LYSMD1 MAFG MAPRE1 MFAP1 MID1 MIPOL1 MISP MITF MORN3 MRPL53 NCDN NFIC NFIX NFKBID NFYC NGLY1 NKIRAS2 PATJ PBX1 PCP4 PDE4C PICK1 PIN1 PKNOX1 POLR3C POLR3GL PPIL4 PRKAG1 PROX1 PSORS1C2 QRICH1 RANBP3 RAX RB1 RGS3 RNF111 RSPH1 SAE1 SEC14L4 SET SHANK3 SIGLEC6 SIM2 SIX3 SLC12A8 SMARCA4 SOD1 SOX10 SOX3 SPDYC SPG21 SRSF11 STAC SUMO1 SUMO3 SYNJ1 TBP TCP11L1 THOC1 TLK1 TLK2 TRAPPC6A TRIM11 TRIP10 TTC3 UBE2F UBE2K UBE3A UBXN2B UBXN7 USHBP1 USP16 USP25 VCX2 VSX2 WASHC3 WDR4 ZBED1 ZNF124 ZNF410
Entrez ID		3198	5080
HPRD ID		00843	06167
Ensembl ID		ENSG00000105991	ENSG00000007372
Uniprot IDs		E7ERT8 P49639	A0A1W2PQG7 A0A1W2PRA8 A0A1W2PSB5 D1KF47 F1T0F8 P26367 Q66SS1
PDB IDs			2CUE 6PAX
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Protein Binding Epidermis Development Extracellular Matrix Hair Cycle Extracellular Matrix Structural Constituent Structural Constituent Of Skin Epidermis Tissue Development Integrin Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Calcium Ion Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Intermediate Filament Organization Basement Membrane Microfibril Identical Protein Binding Regulation Of Cellular Response To Growth Factor Stimulus Developmental Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Animal Organ Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Phospholipid Scramblase Activity Extracellular Region Morphogenesis Of An Epithelium Negative Regulation Of Cellular Response To Growth Factor Stimulus Plasma Membrane Phospholipid Scrambling Anatomical Structure Morphogenesis Elastic Fiber Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Structural Molecule Activity Tissue Morphogenesis Heparin Binding Roundabout Binding Embryonic Morphogenesis Extracellular Space Negative Regulation Of Biomineral Tissue Development Embryonic Hindlimb Morphogenesis Post-embryonic Eye Morphogenesis Extracellular Matrix Assembly Cell Fate Commitment TRAF2-GSTP1 Complex Vasculogenesis Lead Ion Binding Susceptibility To T Cell Mediated Cytotoxicity Lung Growth Regionalization Skeletal System Development	Protein Binding Nucleus Chromatin Sequence-specific Double-stranded DNA Binding Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Nucleoplasm DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Pattern Specification Process Eye Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sensory Organ Development Identical Protein Binding Camera-type Eye Development Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Sequence-specific DNA Binding Protein Localization To Microtubule Negative Regulation Of Transcription By RNA Polymerase II Regionalization PML Body DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gland Development Regulation Of Nucleobase-containing Compound Metabolic Process Protein Polymerization TRNA Methyltransferase Activator Activity Positive Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Metabolic Process Embryonic Morphogenesis Mitotic Spindle Astral Microtubule End Brain Development Ubiquitin Binding Regulation Of Gene Expression Neuron Differentiation Lens Induction In Camera-type Eye
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