HOXA1 and HEXB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOXA1	HEXB
Description		homeobox A1	hexosaminidase subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Membrane Cytoplasmic Vesicle Azurophil Granule Lumen Azurophil Granule Lysosomal Lumen Cortical Granule Extracellular Exosome Beta-N-acetylhexosaminidase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-N-acetylhexosaminidase Activity Protein Binding Acetylglucosaminyltransferase Activity Hexosaminidase Activity Beta-N-acetylglucosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Sensory Perception Of Sound Optokinetic Behavior Anatomical Structure Morphogenesis Abducens Nerve Formation Outer Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Neurocranium Morphogenesis Inner Ear Development Artery Morphogenesis Regulation Of Behavior Cognition Neuromuscular Process Artery Development Semicircular Canal Formation Cochlea Development Cochlea Morphogenesis	Skeletal System Development Carbohydrate Metabolic Process N-acetylglucosamine Metabolic Process N-glycan Processing Lipid Metabolic Process Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Intracellular Calcium Ion Homeostasis Lysosome Organization Single Fertilization Penetration Of Zona Pellucida Sensory Perception Of Sound Locomotory Behavior Male Courtship Behavior Regulation Of Cell Shape Phospholipid Biosynthetic Process Oligosaccharide Catabolic Process Regulation Of Metabolic Process Lipid Storage Sexual Reproduction Glycosaminoglycan Metabolic Process Chondroitin Sulfate Proteoglycan Catabolic Process Dermatan Sulfate Proteoglycan Catabolic Process Hyaluronan Catabolic Process Myelination Astrocyte Cell Migration Positive Regulation Of Transcription By RNA Polymerase II Oogenesis Neuromuscular Process Controlling Balance Neuromuscular Process Neuron Cellular Homeostasis Carbohydrate Derivative Metabolic Process
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Keratan sulfate degradation CS/DS degradation Hyaluronan degradation Defective HEXB causes GM2G2 (Hyaluronan metabolism) Neutrophil degranulation Glycosphingolipid catabolism
Drugs			Pyrimethamine 2-Acetamido-2-Deoxy-D-Glucono-1,5-Lactone N-Acetyl-glucosamine thiazoline (2R,3R,4S,5R)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidine
Diseases		Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome	GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Chronic venous disease ( 28374850) Macular thickness ( 30535121) Multiple sclerosis ( 31604244) Small cell lung carcinoma ( 28604730) Tonsillectomy ( 27182965 28928442)	Gut microbiota relative abundance (unassigned genus belonging to family Clostridiales) ( 33208821) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		344 interacting genes: ACOT7 ADAM12 ADAMTSL2 ADAMTSL4 AGAP3 AGRN AGXT ALG13 ALPP AMMECR1 AMOT ANKS1A ARID5A ARMC7 ATG9B ATP23 ATXN2L BAG4 BAHD1 BATF2 BEND5 BLCAP BLZF1 BSCL2 BSDC1 BUD31 C11orf16 CATSPER1 CCDC120 CCDC33 CCN3 CCN4 CCN5 CCNK CD163 CD164 CDPF1 CERCAM CFAP68 CFP CHIC2 CHRD CHRDL2 CIRSR CNFN CNNM3 COL8A1 CREB5 CRELD1 CRELD2 CUTA CXCL16 CYP21A2 CYSRT1 DBF4B DCTN1 DGKQ DKK3 DOCK2 DOCK3 DOK3 DRC4 DTX2 DUSP10 DUSP22 EEF1A1 EFEMP1 EFEMP2 EGFL7 ENKD1 EPDR1 ESM1 ESR2 EVA1B FAAP100 FAM219B FAM221A FBLN1 FBLN2 FBLN5 FBN1 FHL3 FHL5 FN1 FOXH1 FOXN1 FRS3 FST FUCA2 GATA1 GCM2 GDF15 GNE GP9 GPRASP3 GPS2 GRN GSTP1 GUCD1 HEXB HEXIM2 HEY2 HOXB9 HR HSD3B7 ID3 IGFL1 IGFN1 INCA1 INO80B IRX6 ITGB4 JAG2 KCTD9 KDM1A KPRP KRT31 KRT33B KRT34 KRT35 KRT37 KRT38 KRT40 KRT81 KRT82 KRT83 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP15-1 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP23-1 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LAMA5 LAMB2 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LGALS13 LGALS4 LIMS2 LMX1B LNX1 LONRF1 LPXN LTBP1 LTBP3 LTBP4 LUC7L2 MACO1 MAPKBP1 MDFI MEGF6 MEGF8 MFAP2 MGAT5B MKRN3 MLLT11 MYO15B MYPOP N4BP2L2 NBPF19 NCK2 NECTIN2 NEDD9 NEK6 NELL1 NELL2 NFKBID NOTCH1 NOTCH2NLA NOTCH3 NR1D2 NTN4 NUCB1 NXF1 ODF1 OIT3 OPLAH OTX1 P2RY6 PAX6 PBX2 PCSK5 PCYOX1 PCYT2 PHETA1 PIK3R1 PIN1 PITX1 PITX2 PKM PKNOX1 PLA2G10 PLEKHN1 PLLP PLSCR1 PLSCR2 PLSCR3 PLSCR4 PRICKLE4 PRMT6 PROP1 PSMB1 PTH1R PVR PYCR3 QARS1 R3HDM1 RALGDS RANBP3 RBCK1 RBP3 RBPMS RCHY1 RGS17 RGS19 RGS20 RNF208 RSPO2 RTN4R SAXO4 SCT SDCBP SIVA1 SLC15A3 SLC23A1 SLIT1 SLIT2 SLPI SMCP SND1 SNRPB SNRPC SPATA12 SPATA18 SPRY1 SPRY2 SPRY3 SPRY4 SSC4D SSUH2 STX11 SUV39H1 TBC1D10C TBR1 TBX15 TCF19 TCF3 TEKT4 TEKT5 TGFB1 TGFB1I1 TGM7 THAP7 TLE5 TNS2 TRAF1 TRAF2 TRAF4 TRAPPC6A TRIM42 TRIM55 TRIM63 TRIM8 TRIP6 TSPAN4 UBL5 UNKL VASN VWC2 VWC2L VWCE VWF WDR83 WWOX YIPF3 YPEL3 ZBTB16 ZFTRAF1 ZIM2 ZMAT1 ZNF417 ZNF587 ZNF688 ZNF774 ZNF837 ZNF843 ZNRF3	6 interacting genes: AIRE CSNK2B EIF2D FAM210B HOXA1 TMEM14B
Entrez ID		3198	3074
HPRD ID		00843	06043
Ensembl ID		ENSG00000105991	ENSG00000049860
Uniprot IDs		E7ERT8 P49639	A0A024RAJ6 P07686 Q5URX0
PDB IDs			1NOU 1NOW 1NP0 1O7A 2GJX 2GK1 3LMY 5BRO
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Protein Binding Epidermis Development Extracellular Matrix Hair Cycle Extracellular Matrix Structural Constituent Structural Constituent Of Skin Epidermis Tissue Development Integrin Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Calcium Ion Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Intermediate Filament Organization Basement Membrane Microfibril Identical Protein Binding Regulation Of Cellular Response To Growth Factor Stimulus Developmental Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Animal Organ Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Phospholipid Scramblase Activity Extracellular Region Morphogenesis Of An Epithelium Negative Regulation Of Cellular Response To Growth Factor Stimulus Plasma Membrane Phospholipid Scrambling Anatomical Structure Morphogenesis Elastic Fiber Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Structural Molecule Activity Tissue Morphogenesis Heparin Binding Roundabout Binding Embryonic Morphogenesis Extracellular Space Negative Regulation Of Biomineral Tissue Development Embryonic Hindlimb Morphogenesis Post-embryonic Eye Morphogenesis Extracellular Matrix Assembly Cell Fate Commitment TRAF2-GSTP1 Complex Vasculogenesis Lead Ion Binding Susceptibility To T Cell Mediated Cytotoxicity Lung Growth Regionalization Skeletal System Development	Regulation Of Thymocyte Migration Central Tolerance Induction To Self Antigen Central Tolerance Induction Tolerance Induction Dependent Upon Immune Response Thymus Epithelium Morphogenesis Peripheral T Cell Tolerance Induction Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Viral Process Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Identical Protein Binding Tolerance Induction To Self Antigen Release From Viral Latency T Cell Tolerance Induction Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Adiponectin-activated Signaling Pathway Formation Of Translation Preinitiation Complex Embryonic Neurocranium Morphogenesis Outer Ear Morphogenesis Negative Thymic T Cell Selection Negative T Cell Selection Female Germ Cell Nucleus Tube Morphogenesis Endothelial Tube Morphogenesis IRES-dependent Viral Translational Initiation
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