PIK3R2 and IGF1R

Number of citations of the paper that reports this interaction (PMID 7541045)
28

Data Source:
HPRD (in vitro)

		PIK3R2	IGF1R
Gene Name		phosphoinositide-3-kinase, regulatory subunit 2 (beta)	insulin-like growth factor 1 receptor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Phosphatidylinositol 3-kinase Complex	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Neuron Projection Intracellular Membrane-bounded Organelle Receptor Complex
	Molecular Function	Protein Binding 1-phosphatidylinositol-3-kinase Activity Protein Phosphatase Binding Receptor Tyrosine Kinase Binding Phosphatidylinositol 3-kinase Regulator Activity	G-protein Alpha-subunit Binding Protein Tyrosine Kinase Activity Insulin-like Growth Factor-activated Receptor Activity Insulin Receptor Binding Protein Binding Insulin-like Growth Factor Binding ATP Binding Insulin-like Growth Factor I Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding
	Biological Process	Cellular Glucose Homeostasis Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Phosphatidylinositol 3-kinase Signaling Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Phosphatidylinositol-3-phosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Small GTPase Mediated Signal Transduction	Immune Response Signal Transduction Axonogenesis Brain Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Negative Regulation Of Muscle Cell Apoptotic Process Phosphatidylinositol 3-kinase Signaling Establishment Of Cell Polarity Male Sex Determination Positive Regulation Of Cell Migration Mammary Gland Development Exocrine Pancreas Development Positive Regulation Of Cytokinesis Response To Vitamin E Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of DNA Replication Positive Regulation Of Mitotic Nuclear Division Regulation Of JNK Cascade Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Tetramerization Protein Heterooligomerization Inactivation Of MAPKK Activity Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Prostate Gland Epithelium Morphogenesis Positive Regulation Of Steroid Hormone Biosynthetic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Interleukin-7 signaling Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Signaling by Interleukins TCR signaling Signaling by VEGF Signaling by Rho GTPases Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Downstream TCR signaling Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Rho GTPase cycle Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling PI3K Cascade	IRS-related events triggered by IGF1R Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R IGF1R signaling cascade
Drugs			Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Alpha-D-Mannose Phosphoaminophosphonic Acid-Adenylate Ester (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE
Diseases
GWAS			Arthritis (juvenile idiopathic) ( 22354554) Height ( 20881960) Urate levels ( 23263486)
Protein-Protein Interactions		51 interactors: APP ARRB1 AXL CBL CD28 CRKL CSF1 CSF1R DYDC1 EGF EGFR EPHA2 ERBB2 ERBB3 ERBB4 FBXL2 FGFR1 FYN GOLGA2 GRB2 GRN HCK IGF1R IKZF3 IRS1 IRS2 KIT KRAS KRT15 KRT20 KRT38 LAMB2 LTBP3 MRFAP1L1 PDGFRB PIK3CD RINT1 SEPT2 SHC1 SOCS1 SOCS6 SOCS7 SOS1 STAB1 SYK TEC TGFBR1 TGFBR2 TRIM23 WASF3 YWHAB	59 interactors: AMY2A APP ARHGEF12 CAV1 CBL CRK CRKL CSK DOK4 DOK5 EEA1 EHD1 ESR1 FFAR2 GIPC1 GNAI1 GNAI2 GNB2L1 GRB10 GRB14 IGF1 IGF2 IGFBP3 INS INSR IRS1 IRS2 IRS4 ITGB1 JAK1 JAK2 KCNIP3 KL KRT27 MAP3K5 MDM2 NEDD4 PIK3R1 PIK3R2 PIK3R3 PRKCD PRKD1 PTPN1 PTPN11 RASA1 RPL11 SH2B1 SHC1 SOCS1 SOCS2 SOCS3 SRC STAT3 UBC VAV3 YWHAB YWHAE YWHAG YWHAZ
Entrez ID		5296	3480
HPRD ID		04404	00932
Ensembl ID		ENSG00000105647	ENSG00000140443
Uniprot IDs		O00459	C9J5X1 P08069
PDB IDs		2KT1 2XS6 3MTT 3O5Z	1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Growth Factor Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Immune Response-regulating Signaling Pathway Regulation Of Kinase Activity Intracellular Signal Transduction Cellular Response To Organic Substance Defense Response Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Immune System Process Immune Response Regulation Of Immune System Process Regulation Of Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Response To Stress Regulation Of Protein Kinase Activity Regulation Of Immune Response Regulation Of Cell Proliferation Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Developmental Process Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Signal Transduction Signaling Anatomical Structure Development Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Cell Communication	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Peptide Hormone Stimulus Regulation Of Signal Transduction Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Peptide Regulation Of Kinase Activity Cellular Response To Organonitrogen Compound Signal Transduction Signaling Response To Organic Substance Cellular Response To Hormone Stimulus Cell Communication Response To Hormone Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Cellular Response To Stimulus Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Organonitrogen Compound Insulin Receptor Signaling Pathway Response To Growth Factor Wound Healing Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Response To Insulin Response To Stress Response To Wounding Regulation Of Protein Kinase Activity Defense Response Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of MAPK Cascade Response To Stimulus Positive Regulation Of Transport Regulation Of Immune Response Regulation Of Cell Death
Tagcloud ?		acetylated acetylations chip contrary deacetylase deacetylases distally dysregulated encompassing facilitates featured h2a h3k9 hexokinase hk2 irs2 l6 lysines myotubes p85beta pharmacologically responsive reverted template treatable trichostatin tsa tss z	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		acetylated acetylations chip contrary deacetylase deacetylases distally dysregulated encompassing facilitates featured h2a h3k9 hexokinase hk2 irs2 l6 lysines myotubes p85beta pharmacologically responsive reverted template treatable trichostatin tsa tss z	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?