IGF1R and EHD1

Number of citations of the paper that reports this interaction (PMID 11423532)
33

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		IGF1R	EHD1
Gene Name		insulin-like growth factor 1 receptor	EH-domain containing 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Neuron Projection Intracellular Membrane-bounded Organelle Receptor Complex	Lipid Particle Plasma Membrane Endosome Membrane Membrane Platelet Dense Tubular Network Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Protein Tyrosine Kinase Activity Insulin-like Growth Factor-activated Receptor Activity Insulin Receptor Binding Protein Binding Insulin-like Growth Factor Binding ATP Binding Insulin-like Growth Factor I Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding	Calcium Ion Binding Protein Binding ATP Binding GTP Binding Rab GTPase Binding
	Biological Process	Immune Response Signal Transduction Axonogenesis Brain Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Negative Regulation Of Muscle Cell Apoptotic Process Phosphatidylinositol 3-kinase Signaling Establishment Of Cell Polarity Male Sex Determination Positive Regulation Of Cell Migration Mammary Gland Development Exocrine Pancreas Development Positive Regulation Of Cytokinesis Response To Vitamin E Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of DNA Replication Positive Regulation Of Mitotic Nuclear Division Regulation Of JNK Cascade Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Tetramerization Protein Heterooligomerization Inactivation Of MAPKK Activity Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Prostate Gland Epithelium Morphogenesis Positive Regulation Of Steroid Hormone Biosynthetic Process	Intracellular Protein Transport Endocytosis Blood Coagulation Positive Regulation Of Cholesterol Storage Neuron Projection Development Endocytic Recycling Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Protein Homooligomerization Positive Regulation Of Myoblast Fusion Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Endocytic Recycling
Pathways		IRS-related events triggered by IGF1R Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R IGF1R signaling cascade	Factors involved in megakaryocyte development and platelet production
Drugs		Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Alpha-D-Mannose Phosphoaminophosphonic Acid-Adenylate Ester (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 22354554) Height ( 20881960) Urate levels ( 23263486)
Protein-Protein Interactions		59 interactors: AMY2A APP ARHGEF12 CAV1 CBL CRK CRKL CSK DOK4 DOK5 EEA1 EHD1 ESR1 FFAR2 GIPC1 GNAI1 GNAI2 GNB2L1 GRB10 GRB14 IGF1 IGF2 IGFBP3 INS INSR IRS1 IRS2 IRS4 ITGB1 JAK1 JAK2 KCNIP3 KL KRT27 MAP3K5 MDM2 NEDD4 PIK3R1 PIK3R2 PIK3R3 PRKCD PRKD1 PTPN1 PTPN11 RASA1 RPL11 SH2B1 SHC1 SOCS1 SOCS2 SOCS3 SRC STAT3 UBC VAV3 YWHAB YWHAE YWHAG YWHAZ	12 interactors: ANKFY1 AP2A1 CLTC EHBP1 EHD3 IGF1R MICAL1 MICALL1 PLA2G4A RAB11FIP2 RBSN SNAP29
Entrez ID		3480	10938
HPRD ID		00932	09325
Ensembl ID		ENSG00000140443	ENSG00000110047
Uniprot IDs		C9J5X1 P08069	B2R5U3 Q9H4M9
PDB IDs		1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU	2JQ6 2KFF 2KFG 2KFH 2KSP
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Peptide Hormone Stimulus Regulation Of Signal Transduction Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Peptide Regulation Of Kinase Activity Cellular Response To Organonitrogen Compound Signal Transduction Signaling Response To Organic Substance Cellular Response To Hormone Stimulus Cell Communication Response To Hormone Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Cellular Response To Stimulus Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Organonitrogen Compound Insulin Receptor Signaling Pathway Response To Growth Factor Wound Healing Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Response To Insulin Response To Stress Response To Wounding Regulation Of Protein Kinase Activity Defense Response Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of MAPK Cascade Response To Stimulus Positive Regulation Of Transport Regulation Of Immune Response Regulation Of Cell Death	Vesicle-mediated Transport Negative Regulation Of Hyaluronan Biosynthetic Process Endosomal Transport Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Protein Transport Establishment Of Protein Localization Cellular Localization Membrane Organization Endocytic Recycling Protein Localization Endocytosis Transport Golgi Vesicle Transport Intracellular Transport Vesicle Fusion Receptor-mediated Endocytosis Intracellular Protein Transport Inactivation Of MAPKK Activity Slow Endocytic Recycling Organelle Fusion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Establishment Of Cell Polarity Endosomal Vesicle Fusion Golgi To Lysosome Transport Positive Regulation Of Pinocytosis Membrane Fusion Regulation Of Body Fluid Levels Cellular Protein Localization Platelet Activating Factor Biosynthetic Process Regulation Of Carbohydrate Metabolic Process Secretion Protein Targeting To Membrane Platelet Activating Factor Metabolic Process Insulin Secretion Involved In Cellular Response To Glucose Stimulus Establishment Or Maintenance Of Cell Polarity Endosome Localization Cardiolipin Acyl-chain Remodeling Sulfur Oxidation Positive Regulation Of Steroid Hormone Biosynthetic Process Exocrine Pancreas Development Golgi To Vacuole Transport Vesicle Organization Autophagic Vacuole Fusion Protein Localization To Endosome Regulation Of Cardiac Muscle Cell Membrane Potential Plasma Membrane Organization Synaptic Vesicle Priming
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	accurate complex2 date1 encode flowering h3k27me3 hd3a heading involve ld oslf photoperiod polycomb prc2 presently promotion repressed repression repressive repressor rft1 rice sd sdg711 sdg718 trimethylation z zeste
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	accurate complex2 date1 encode flowering h3k27me3 hd3a heading involve ld oslf photoperiod polycomb prc2 presently promotion repressed repression repressive repressor rft1 rice sd sdg711 sdg718 trimethylation z zeste
Tagcloud (Intersection) ?