PIK3R2 and LAMB2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PIK3R2	LAMB2
Gene Name		phosphoinositide-3-kinase, regulatory subunit 2 (beta)	laminin, beta 2 (laminin S)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Phosphatidylinositol 3-kinase Complex	Extracellular Region Basement Membrane Basal Lamina Laminin-3 Complex Extracellular Matrix Laminin-11 Complex Synapse Extracellular Vesicular Exosome
	Molecular Function	Protein Binding 1-phosphatidylinositol-3-kinase Activity Protein Phosphatase Binding Receptor Tyrosine Kinase Binding Phosphatidylinositol 3-kinase Regulator Activity	Integrin Binding Structural Molecule Activity
	Biological Process	Cellular Glucose Homeostasis Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Phosphatidylinositol 3-kinase Signaling Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Phosphatidylinositol-3-phosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Small GTPase Mediated Signal Transduction	Cell Adhesion Axon Guidance Neuromuscular Junction Development Visual Perception Astrocyte Development Schwann Cell Development Extracellular Matrix Organization Axon Extension Involved In Regeneration Retina Development In Camera-type Eye Metanephric Glomerular Visceral Epithelial Cell Development Metanephric Glomerular Basement Membrane Development
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Interleukin-7 signaling Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Signaling by Interleukins TCR signaling Signaling by VEGF Signaling by Rho GTPases Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Downstream TCR signaling Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Rho GTPase cycle Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling PI3K Cascade	Laminin interactions ECM proteoglycans Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		51 interactors: APP ARRB1 AXL CBL CD28 CRKL CSF1 CSF1R DYDC1 EGF EGFR EPHA2 ERBB2 ERBB3 ERBB4 FBXL2 FGFR1 FYN GOLGA2 GRB2 GRN HCK IGF1R IKZF3 IRS1 IRS2 KIT KRAS KRT15 KRT20 KRT38 LAMB2 LTBP3 MRFAP1L1 PDGFRB PIK3CD RINT1 SEPT2 SHC1 SOCS1 SOCS6 SOCS7 SOS1 STAB1 SYK TEC TGFBR1 TGFBR2 TRIM23 WASF3 YWHAB	8 interactors: ATXN7 KPNA2 ORC5 PIK3R2 PLEKHA5 RBL1 STAT3 ZNF512B
Entrez ID		5296	3913
HPRD ID		04404	01034
Ensembl ID		ENSG00000105647	ENSG00000172037
Uniprot IDs		O00459	P55268
PDB IDs		2KT1 2XS6 3MTT 3O5Z
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Growth Factor Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Immune Response-regulating Signaling Pathway Regulation Of Kinase Activity Intracellular Signal Transduction Cellular Response To Organic Substance Defense Response Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Immune System Process Immune Response Regulation Of Immune System Process Regulation Of Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Response To Stress Regulation Of Protein Kinase Activity Regulation Of Immune Response Regulation Of Cell Proliferation Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Developmental Process Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Signal Transduction Signaling Anatomical Structure Development Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Cell Communication	Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Viral Process Protein Import Into Nucleus Nuclear Import Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Protein Import Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Protein Localization To Nucleus Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Glucose Homeostasis Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Glycolytic Process Cellular Macromolecule Biosynthetic Process Radial Glial Cell Differentiation Macromolecule Biosynthetic Process Nucleocytoplasmic Transport Nuclear Transport Regulation Of Lipid Metabolic Process Transcription, DNA-templated Cellular Response To Peptide Hormone Stimulus Interleukin-6-mediated Signaling Pathway Cellular Response To Peptide RNA Biosynthetic Process Establishment Of Protein Localization To Organelle Response To Organic Substance Regulation Of Transcription, DNA-templated Histone Deubiquitination Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process NLS-bearing Protein Import Into Nucleus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation
Tagcloud ?		acetylated acetylations chip contrary deacetylase deacetylases distally dysregulated encompassing facilitates featured h2a h3k9 hexokinase hk2 irs2 l6 lysines myotubes p85beta pharmacologically responsive reverted template treatable trichostatin tsa tss z
Tagcloud (Difference) ?		acetylated acetylations chip contrary deacetylase deacetylases distally dysregulated encompassing facilitates featured h2a h3k9 hexokinase hk2 irs2 l6 lysines myotubes p85beta pharmacologically responsive reverted template treatable trichostatin tsa tss z
Tagcloud (Intersection) ?