IGF1R and DOK4

Number of citations of the paper that reports this interaction (PMID 12730241)
33

Data Source:
HPRD (in vitro)

		IGF1R	DOK4
Gene Name		insulin-like growth factor 1 receptor	docking protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Neuron Projection Intracellular Membrane-bounded Organelle Receptor Complex
	Molecular Function	G-protein Alpha-subunit Binding Protein Tyrosine Kinase Activity Insulin-like Growth Factor-activated Receptor Activity Insulin Receptor Binding Protein Binding Insulin-like Growth Factor Binding ATP Binding Insulin-like Growth Factor I Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding	Receptor Signaling Protein Activity Insulin Receptor Binding Protein Binding
	Biological Process	Immune Response Signal Transduction Axonogenesis Brain Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Negative Regulation Of Muscle Cell Apoptotic Process Phosphatidylinositol 3-kinase Signaling Establishment Of Cell Polarity Male Sex Determination Positive Regulation Of Cell Migration Mammary Gland Development Exocrine Pancreas Development Positive Regulation Of Cytokinesis Response To Vitamin E Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of DNA Replication Positive Regulation Of Mitotic Nuclear Division Regulation Of JNK Cascade Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Tetramerization Protein Heterooligomerization Inactivation Of MAPKK Activity Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Prostate Gland Epithelium Morphogenesis Positive Regulation Of Steroid Hormone Biosynthetic Process	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development
Pathways		IRS-related events triggered by IGF1R Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R IGF1R signaling cascade
Drugs		Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Alpha-D-Mannose Phosphoaminophosphonic Acid-Adenylate Ester (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 22354554) Height ( 20881960) Urate levels ( 23263486)
Protein-Protein Interactions		59 interactors: AMY2A APP ARHGEF12 CAV1 CBL CRK CRKL CSK DOK4 DOK5 EEA1 EHD1 ESR1 FFAR2 GIPC1 GNAI1 GNAI2 GNB2L1 GRB10 GRB14 IGF1 IGF2 IGFBP3 INS INSR IRS1 IRS2 IRS4 ITGB1 JAK1 JAK2 KCNIP3 KL KRT27 MAP3K5 MDM2 NEDD4 PIK3R1 PIK3R2 PIK3R3 PRKCD PRKD1 PTPN1 PTPN11 RASA1 RPL11 SH2B1 SHC1 SOCS1 SOCS2 SOCS3 SRC STAT3 UBC VAV3 YWHAB YWHAE YWHAG YWHAZ	11 interactors: CRK EGFR ERBB2 FYN IGF1R INSR OPRM1 RASA1 RET SRC TEK
Entrez ID		3480	55715
HPRD ID		00932	16316
Ensembl ID		ENSG00000140443	ENSG00000125170
Uniprot IDs		C9J5X1 P08069	H3BQ19 Q8TEW6
PDB IDs		1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Peptide Hormone Stimulus Regulation Of Signal Transduction Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Peptide Regulation Of Kinase Activity Cellular Response To Organonitrogen Compound Signal Transduction Signaling Response To Organic Substance Cellular Response To Hormone Stimulus Cell Communication Response To Hormone Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Cellular Response To Stimulus Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Organonitrogen Compound Insulin Receptor Signaling Pathway Response To Growth Factor Wound Healing Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Response To Insulin Response To Stress Response To Wounding Regulation Of Protein Kinase Activity Defense Response Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of MAPK Cascade Response To Stimulus Positive Regulation Of Transport Regulation Of Immune Response Regulation Of Cell Death	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Protein Kinase B Signaling Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Positive Regulation Of Phosphorylation Peptidyl-amino Acid Modification Regulation Of Catalytic Activity Peptidyl-tyrosine Autophosphorylation Regulation Of Protein Kinase B Signaling Response To Growth Factor Response To Organic Substance Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cellular Response To Organic Substance Intracellular Signal Transduction Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Component Organization Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Kinase Activity Regulation Of ERK1 And ERK2 Cascade Response To Peptide Hormone Immune System Process Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Response To Peptide Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Response To Hormone Neuron Development Generation Of Neurons Axonogenesis Anatomical Structure Morphogenesis
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	17p12 19q13 4q27 5p13 7q36 9q34 amacr bcl3 ccl17 ccl22 cd30 cdk9 chemoresponsive cnas cx3cl1 encompassed id4 il10 il21 lcn2 nell1 nonrandom ppargc1a ptges recurring reed spry1 sternberg txnip
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	17p12 4q27 5p13 7q36 9q34 amacr bcl3 ccl17 ccl22 cd30 cdk9 chemoresponsive cnas cx3cl1 encompassed id4 il10 il21 lcn2 nell1 nonrandom ppargc1a ptges recurring reed spry1 sternberg txnip
Tagcloud (Intersection) ?		19q13