Wiki-Pi
About
Search
People
Updates
Search
PIK3R2 and TRIM23
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
PIK3R2
TRIM23
Description
phosphoinositide-3-kinase regulatory subunit 2
tripartite motif containing 23
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Focal Adhesion
Phosphatidylinositol 3-kinase Complex, Class IA
Golgi Membrane
Nucleus
Cytoplasm
Lysosome
Lysosomal Membrane
Golgi Apparatus
Plasma Membrane
Endomembrane System
Membrane
Molecular Function
Phosphotyrosine Residue Binding
GTPase Activator Activity
Protein Binding
Protein Phosphatase Binding
Receptor Tyrosine Kinase Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Nucleotide Binding
GTPase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
GTP Binding
Enzyme Activator Activity
Zinc Ion Binding
Transferase Activity
GDP Binding
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Intracellular Glucose Homeostasis
Immune Response
Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Autophagy
Protein Transport
B Cell Differentiation
T Cell Differentiation
Regulation Of Actin Filament Polymerization
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of MAPK Cascade
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Stress Fiber Assembly
Regulation Of Protein Localization To Plasma Membrane
Immune System Process
Intracellular Protein Transport
Positive Regulation Of Autophagy
Vesicle-mediated Transport
Protein Ubiquitination
Innate Immune Response
Pathways
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
Downstream signal transduction
PI3K/AKT activation
Signaling by ALK
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
RHOA GTPase cycle
Extra-nuclear estrogen signaling
RHOB GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOF GTPase cycle
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
Signaling by ALK fusions and activated point mutants
Signaling by LTK in cancer
Signaling by LTK
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Co-stimulation by ICOS
Drugs
SF1126
Diseases
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Mental health study participation (completed survey) (
31263887
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
60 interacting genes:
APP
APPL1
AR
ARRB1
AXL
CBL
CD28
CRK
CRKL
CSF1R
DYDC1
EGF
EGFR
ENKUR
EPHA2
ERBB2
ERBB3
ERBB4
FBXL2
FGFR1
FYN
GAB1
GHR
GOLGA2
GRB2
GRN
HCK
IGF1R
IKZF3
IRS1
IRS2
KIT
KRAS
KRT15
KRT20
KRT38
LAMB2
LMNA
LTBP3
MET
MRFAP1L1
PDGFRB
PIK3CB
PIK3CD
RINT1
SEPTIN2
SHC1
SOCS1
SOCS6
SOCS7
SOS1
STAB1
STAT3
SYK
TEC
TGFBR1
TGFBR2
TRIM23
WASF3
YWHAB
219 interacting genes:
ACTN4
AKTIP
ANKRD36BP1
ANKRD55
ANO1
AP3M1
AQP1
ARFGAP1
ARHGEF3
ARNT2
ATPAF2
ATXN7
BAG1
BAZ2B
BICRAL
BRME1
C8orf33
CARD9
CATSPERT
CBX8
CCDC13
CCDC146
CCDC25
CCDC33
CDC20B
CDC73
CDR2
CFAP53
CHP1P2
CIMIP4
COX5B
CPNE7
CREB5
CSRP2
CWF19L2
CXCL14
CYTH1
CYTH2
DCX
DEPP1
DMC1
DMRT3
DNAAF4
DOCK2
EAF2
EHHADH
EIF3D
ENKD1
EPN2
EXOC3-AS1
FAM110A
FAM133A
FAM193B
FAM83A
FAM90A1
FBF1
FHIT
FLAD1
FXR2
GAD1
GATA2
GCC2-AS1
GEM
GGA2
GGA3
GLIDR
GMCL2
GPANK1
GPKOW
HAPLN2
HAUS1
HGS
HNRNPLL
HOXB5
HSPB7
IL16
IQCE
IQUB
JOSD1
JRK
KAT5
KIFC3
KLHL42
KRT6A
KRT75
KRT76
LAGE3
LENG1
LGALS14
LGALS3
LGALS8
LINC00526
LINC01018
LMO2
LMO3
LNX1
MDM2
MKRN3
MLH1
MORN4
MRPL4
MRPL45
MSRB3
MTFR2
MYEF2
MYOM1
MYOZ1
NAB2
NEDD9
NEK6
NFU1
NOXA1
NTAQ1
NUDT21
NXT2
PDE4D
PHF1
PIAS2
PIK3R2
PITX1
PKP4
PLEKHA2
POLI
POLL
POM121
PPIL2
PPP1R15B
PPP1R18
PRPF18
PRPF31
PSMA1
PSMB1
RAD18
RAMAC
RCAN3
RIBC1
RIBC2
RIN1
RNF126
RNF213
RNF32
RNF34
RNF6
RSRC2
RTP5
RUFY1
SCNM1
SF1
SH2D4A
SIAH1
SIRPA
SLC25A6
SMG9
SNAI1
SNAI2
SNRPB
SNRPB2
SNW1
SORBS3
SPG21
SUMO1P1
TACO1
TASOR2
TBC1D22B
TCEA2
TCEANC
TEPSIN
TMSB4X
TNFAIP3
TRAF1
TRAIP
TRIM27
TRIM29
TRIM31
TRIM32
TRIM42
TRIM55
TRIM63
TROAP
TSEN54
TSG101
TSHZ3
TXNDC5
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2H
UBE2I
UBE2L3
UBE2N
UBE2U
UBE2W
UBOX5
UBQLN1
USP2
USP20
USP21
UTP23
VGLL1
WDR25
WHR1
ZBTB16
ZBTB4
ZC2HC1C
ZFAND2A
ZNF20
ZNF250
ZNF408
ZNF417
ZNF474
ZNF564
ZNF581
ZNF587
ZNF688
ZNF835
Entrez ID
5296
373
HPRD ID
04404
03449
Ensembl ID
ENSG00000105647
ENSG00000113595
Uniprot IDs
O00459
P36406
PDB IDs
2KT1
2XS6
3MTT
3O5Z
6OX7
6U28
7RCH
7RNU
5VZV
5VZW
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Protein Tyrosine Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Signal Transduction
Receptor Complex
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Population Proliferation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Regulation Of Cell Migration
Regulation Of Cell Motility
Intracellular Signal Transduction
Positive Regulation Of Cell Migration
Regulation Of Cell Population Proliferation
Regulation Of Developmental Process
Regulation Of MAPK Cascade
Positive Regulation Of Cell Motility
Regulation Of Locomotion
Positive Regulation Of Locomotion
Kinase Activity
Positive Regulation Of MAPK Cascade
Protein Kinase Activity
Developmental Process
Peptidyl-tyrosine Phosphorylation
Response To Growth Factor
Positive Regulation Of Multicellular Organismal Process
Insulin-like Growth Factor Receptor Signaling Pathway
Cellular Developmental Process
Cellular Response To Growth Factor Stimulus
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Programmed Cell Death
Regulation Of Multicellular Organismal Development
Cell Population Proliferation
Growth Factor Binding
Positive Regulation Of Epithelial Cell Proliferation
Phosphotyrosine Residue Binding
Regulation Of Programmed Cell Death
Morphogenesis Of An Epithelium
ERBB Signaling Pathway
Tissue Morphogenesis
Protein Binding
Protein Polyubiquitination
Ubiquitin Conjugating Enzyme Activity
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Protein Ubiquitination
Ubiquitin-protein Transferase Activity
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Nucleus
Ubiquitin Protein Ligase Activity
Proteolysis Involved In Protein Catabolic Process
Protein K63-linked Ubiquitination
Zinc Ion Binding
Protein Modification Process
Ubiquitin-protein Transferase Activator Activity
Macromolecule Catabolic Process
Protein Monoubiquitination
Proteolysis
Ubiquitin Protein Ligase Binding
Protein K11-linked Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin Binding
SUMO Transferase Activity
Spliceosomal Complex
Nuclear Speck
Proteasomal Protein Catabolic Process
Macromolecule Metabolic Process
Establishment Of Protein Localization To Vacuole
MRNA Processing
Spindle Pole
Identical Protein Binding
Protein Metabolic Process
Metal Ion Binding
SnRNP Binding
Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
Striated Muscle Myosin Thick Filament
Cytoplasm
Protein Sumoylation
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?