IGF1R and FFAR2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IGF1R	FFAR2
Gene Name		insulin-like growth factor 1 receptor	free fatty acid receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Neuron Projection Intracellular Membrane-bounded Organelle Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Cell Projection
	Molecular Function	G-protein Alpha-subunit Binding Protein Tyrosine Kinase Activity Insulin-like Growth Factor-activated Receptor Activity Insulin Receptor Binding Protein Binding Insulin-like Growth Factor Binding ATP Binding Insulin-like Growth Factor I Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding	G-protein Coupled Receptor Activity Protein Binding Lipid Binding
	Biological Process	Immune Response Signal Transduction Axonogenesis Brain Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Negative Regulation Of Muscle Cell Apoptotic Process Phosphatidylinositol 3-kinase Signaling Establishment Of Cell Polarity Male Sex Determination Positive Regulation Of Cell Migration Mammary Gland Development Exocrine Pancreas Development Positive Regulation Of Cytokinesis Response To Vitamin E Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of DNA Replication Positive Regulation Of Mitotic Nuclear Division Regulation Of JNK Cascade Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Tetramerization Protein Heterooligomerization Inactivation Of MAPKK Activity Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Prostate Gland Epithelium Morphogenesis Positive Regulation Of Steroid Hormone Biosynthetic Process	Leukocyte Chemotaxis Involved In Inflammatory Response Mucosal Immune Response Regulation Of Acute Inflammatory Response Positive Regulation Of Cytokine Production Involved In Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus G-protein Coupled Receptor Signaling Pathway Lipid Storage Positive Regulation Of Chemokine Production Glucose Homeostasis Fat Cell Differentiation Cellular Response To Fatty Acid Regulation Of Peptide Hormone Secretion Positive Regulation Of Interleukin-8 Secretion
Pathways		IRS-related events triggered by IGF1R Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R IGF1R signaling cascade	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Free fatty acid receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Alpha-D-Mannose Phosphoaminophosphonic Acid-Adenylate Ester (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 22354554) Height ( 20881960) Urate levels ( 23263486)
Protein-Protein Interactions		59 interactors: AMY2A APP ARHGEF12 CAV1 CBL CRK CRKL CSK DOK4 DOK5 EEA1 EHD1 ESR1 FFAR2 GIPC1 GNAI1 GNAI2 GNB2L1 GRB10 GRB14 IGF1 IGF2 IGFBP3 INS INSR IRS1 IRS2 IRS4 ITGB1 JAK1 JAK2 KCNIP3 KL KRT27 MAP3K5 MDM2 NEDD4 PIK3R1 PIK3R2 PIK3R3 PRKCD PRKD1 PTPN1 PTPN11 RASA1 RPL11 SH2B1 SHC1 SOCS1 SOCS2 SOCS3 SRC STAT3 UBC VAV3 YWHAB YWHAE YWHAG YWHAZ	4 interactors: CYB5R2 GNAO1 GNAQ IGF1R
Entrez ID		3480	2867
HPRD ID		00932	04824
Ensembl ID		ENSG00000140443	ENSG00000126262
Uniprot IDs		C9J5X1 P08069	C6KYL4 O15552
PDB IDs		1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Peptide Hormone Stimulus Regulation Of Signal Transduction Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Peptide Regulation Of Kinase Activity Cellular Response To Organonitrogen Compound Signal Transduction Signaling Response To Organic Substance Cellular Response To Hormone Stimulus Cell Communication Response To Hormone Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Cellular Response To Stimulus Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Organonitrogen Compound Insulin Receptor Signaling Pathway Response To Growth Factor Wound Healing Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Response To Insulin Response To Stress Response To Wounding Regulation Of Protein Kinase Activity Defense Response Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of MAPK Cascade Response To Stimulus Positive Regulation Of Transport Regulation Of Immune Response Regulation Of Cell Death	Dopamine Receptor Signaling Pathway Brain Development Head Development Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Inactivation Of MAPKK Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuron Development Central Nervous System Development Neuron Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Generation Of Neurons Positive Regulation Of Steroid Hormone Biosynthetic Process Exocrine Pancreas Development Neurogenesis Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Negative Regulation Of Phosphorylation Positive Regulation Of Hormone Biosynthetic Process Cell Development Forebrain Development Regulation Of Melanocyte Differentiation Male Sex Determination Maternal Behavior Response To Vitamin E Insulin-like Growth Factor Receptor Signaling Pathway Nervous System Development Behavior Regulation Of Catenin Import Into Nucleus Regulation Of Catalytic Activity Regulation Of Developmental Pigmentation Phosphatidylinositol 3-kinase Signaling Sex Determination Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Neuron Maturation Positive Regulation Of GTPase Activity Regulation Of Hormone Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Muscle Cell Apoptotic Process Forebrain Neuron Development Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Catalytic Activity Regulation Of GTPase Activity Positive Regulation Of Cytokinesis Regulation Of Kinase Activity Prostate Gland Epithelium Morphogenesis
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	acetate alter autonomous believed coupling elevation encoded expect ffa2 ffa3 ffar3 gi glucose hyperglycemia inability indeed insufficient islets maintain obese pancreatic profound proper respond secretion stimulate summary tolerance worldwide
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	acetate alter autonomous believed coupling elevation encoded expect ffa2 ffa3 ffar3 gi glucose hyperglycemia inability indeed insufficient islets maintain obese pancreatic profound proper respond secretion stimulate summary tolerance worldwide
Tagcloud (Intersection) ?