PIK3R2 and SEPTIN2

Number of citations of the paper that reports this interaction (PubMedID 17024187)
35

Data Source:
HPRD (in vitro)

		PIK3R2	SEPTIN2
Description		phosphoinositide-3-kinase regulatory subunit 2	septin 2
Image
GO Annotations	Cellular Component	Nucleus Cytosol Focal Adhesion Phosphatidylinositol 3-kinase Complex, Class IA	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytoskeleton Plasma Membrane Cilium Axoneme Cell Cortex Septin Ring Cell Surface Actin Cytoskeleton Microtubule Cytoskeleton Membrane Midbody Septin Complex Motile Cilium Cell Division Site Cleavage Furrow Photoreceptor Connecting Cilium Ciliary Transition Zone Cell Projection Intercellular Bridge Synapse Ciliary Membrane Extracellular Exosome Sperm Annulus Non-motile Cilium
	Molecular Function	Phosphotyrosine Residue Binding GTPase Activator Activity Protein Binding Protein Phosphatase Binding Receptor Tyrosine Kinase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Heterodimerization Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Enzyme Regulator Activity Identical Protein Binding Cadherin Binding Molecular Adaptor Activity
	Biological Process	Intracellular Glucose Homeostasis Immune Response Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Autophagy Protein Transport B Cell Differentiation T Cell Differentiation Regulation Of Actin Filament Polymerization Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Regulation Of Protein Localization To Plasma Membrane	Regulation Of L-glutamate Import Across Plasma Membrane Smoothened Signaling Pathway Spermatogenesis Intracellular Protein Localization Cell Differentiation Regulation Of Protein Localization Cell Division Cilium Assembly Cytoskeleton-dependent Cytokinesis
Pathways		PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS	Anchoring of the basal body to the plasma membrane
Drugs		SF1126
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Mental health study participation (completed survey) ( 31263887)	Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		60 interacting genes: APP APPL1 AR ARRB1 AXL CBL CD28 CRK CRKL CSF1R DYDC1 EGF EGFR ENKUR EPHA2 ERBB2 ERBB3 ERBB4 FBXL2 FGFR1 FYN GAB1 GHR GOLGA2 GRB2 GRN HCK IGF1R IKZF3 IRS1 IRS2 KIT KRAS KRT15 KRT20 KRT38 LAMB2 LMNA LTBP3 MET MRFAP1L1 PDGFRB PIK3CB PIK3CD RINT1 SEPTIN2 SHC1 SOCS1 SOCS6 SOCS7 SOS1 STAB1 STAT3 SYK TEC TGFBR1 TGFBR2 TRIM23 WASF3 YWHAB	25 interacting genes: ATP6V0D2 BAZ2B CDC42 CEBPA COG4 CSNK2A1 DAZAP2 DSCAM ESR1 FXR1 JPT2 MTOR PIK3R2 PLEKHF2 RNF31 S100A4 SEPTIN5 SEPTIN6 SEPTIN9 SH3KBP1 SNCA STMN1 STX1A TBC1D21 UBL5
Entrez ID		5296	4735
HPRD ID		04404	03297
Ensembl ID		ENSG00000105647	ENSG00000168385
Uniprot IDs		O00459	A0A384N6H6 B5MCX3 Q15019
PDB IDs		2KT1 2XS6 3MTT 3O5Z 6OX7 6U28 7RCH 7RNU	2QA5 2QAG 2QNR 6UPA 6UPQ 6UPR 7M6J
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Receptor Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Regulation Of Cell Motility Intracellular Signal Transduction Positive Regulation Of Cell Migration Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of MAPK Cascade Positive Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Locomotion Kinase Activity Positive Regulation Of MAPK Cascade Protein Kinase Activity Developmental Process Peptidyl-tyrosine Phosphorylation Response To Growth Factor Positive Regulation Of Multicellular Organismal Process Insulin-like Growth Factor Receptor Signaling Pathway Cellular Developmental Process Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Development Cell Population Proliferation Growth Factor Binding Positive Regulation Of Epithelial Cell Proliferation Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Morphogenesis Of An Epithelium ERBB Signaling Pathway Tissue Morphogenesis	Cell Division Site Septin Ring Septin Complex Identical Protein Binding Organelle Organization Regulation Of Stress Fiber Assembly Cytoskeleton-dependent Cytokinesis Regulation Of Autophagy Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Synaptic Vesicle Positive Regulation Of Cell Growth Regulation Of Intracellular Signal Transduction Cell Differentiation Golgi Transport Complex Protein Destabilization Regulation Of Cytoskeleton Organization SNARE Complex Assembly Neuron Projection Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Catabolic Process Molecular Adaptor Activity Intracellular Protein Localization Negative Regulation Of Microtubule Polymerization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Macroautophagy Regulation Of Signal Transduction Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Neurotransmitter Secretion Regulation Of Organelle Organization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neurotransmitter Secretion Regulation Of Cell Projection Assembly Regulation Of Cell Projection Organization Positive Regulation Of Growth Regulation Of Actin Filament Organization Cellular Developmental Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cellular Component Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Negative Regulation Of Protein-containing Complex Assembly Synaptic Vesicle Exocytosis Positive Regulation Of Protein Targeting To Mitochondrion
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