IGF1R and KL

Number of citations of the paper that reports this interaction (PMID 18762812)
35

Data Source:
HPRD (in vivo)

		IGF1R	KL
Gene Name		insulin-like growth factor 1 receptor	klotho
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Neuron Projection Intracellular Membrane-bounded Organelle Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Protein Tyrosine Kinase Activity Insulin-like Growth Factor-activated Receptor Activity Insulin Receptor Binding Protein Binding Insulin-like Growth Factor Binding ATP Binding Insulin-like Growth Factor I Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding	Beta-glucuronidase Activity Signal Transducer Activity Fibroblast Growth Factor Receptor Binding Hormone Activity Vitamin D Binding Beta-glucosidase Activity Fibroblast Growth Factor Binding
	Biological Process	Immune Response Signal Transduction Axonogenesis Brain Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Negative Regulation Of Muscle Cell Apoptotic Process Phosphatidylinositol 3-kinase Signaling Establishment Of Cell Polarity Male Sex Determination Positive Regulation Of Cell Migration Mammary Gland Development Exocrine Pancreas Development Positive Regulation Of Cytokinesis Response To Vitamin E Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of DNA Replication Positive Regulation Of Mitotic Nuclear Division Regulation Of JNK Cascade Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Tetramerization Protein Heterooligomerization Inactivation Of MAPKK Activity Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Prostate Gland Epithelium Morphogenesis Positive Regulation Of Steroid Hormone Biosynthetic Process	Acute Inflammatory Response Carbohydrate Metabolic Process Energy Reserve Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Aging Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Calcium Ion Homeostasis Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		IRS-related events triggered by IGF1R Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R IGF1R signaling cascade
Drugs		Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Alpha-D-Mannose Phosphoaminophosphonic Acid-Adenylate Ester (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 22354554) Height ( 20881960) Urate levels ( 23263486)
Protein-Protein Interactions		59 interactors: AMY2A APP ARHGEF12 CAV1 CBL CRK CRKL CSK DOK4 DOK5 EEA1 EHD1 ESR1 FFAR2 GIPC1 GNAI1 GNAI2 GNB2L1 GRB10 GRB14 IGF1 IGF2 IGFBP3 INS INSR IRS1 IRS2 IRS4 ITGB1 JAK1 JAK2 KCNIP3 KL KRT27 MAP3K5 MDM2 NEDD4 PIK3R1 PIK3R2 PIK3R3 PRKCD PRKD1 PTPN1 PTPN11 RASA1 RPL11 SH2B1 SHC1 SOCS1 SOCS2 SOCS3 SRC STAT3 UBC VAV3 YWHAB YWHAE YWHAG YWHAZ	1 interactors: IGF1R
Entrez ID		3480	9365
HPRD ID		00932	05316
Ensembl ID		ENSG00000140443	ENSG00000133116
Uniprot IDs		C9J5X1 P08069	Q9UEF7
PDB IDs		1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Peptide Hormone Stimulus Regulation Of Signal Transduction Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Peptide Regulation Of Kinase Activity Cellular Response To Organonitrogen Compound Signal Transduction Signaling Response To Organic Substance Cellular Response To Hormone Stimulus Cell Communication Response To Hormone Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Cellular Response To Stimulus Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Organonitrogen Compound Insulin Receptor Signaling Pathway Response To Growth Factor Wound Healing Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Response To Insulin Response To Stress Response To Wounding Regulation Of Protein Kinase Activity Defense Response Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of MAPK Cascade Response To Stimulus Positive Regulation Of Transport Regulation Of Immune Response Regulation Of Cell Death	Inactivation Of MAPKK Activity Exocrine Pancreas Development Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Hormone Biosynthetic Process Male Sex Determination Response To Vitamin E Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Sex Determination Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Hormone Metabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Cytokinesis Prostate Gland Epithelium Morphogenesis Positive Regulation Of Mitotic Nuclear Division Prostate Gland Morphogenesis Regulation Of Muscle Cell Apoptotic Process Regulation Of Cytokinesis Exocrine System Development Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of DNA Replication Prostate Gland Development Regulation Of Steroid Biosynthetic Process Positive Regulation Of Protein Kinase B Signaling Pancreas Development Regulation Of Steroid Metabolic Process Protein Tetramerization Response To Vitamin Establishment Of Cell Polarity Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Mitotic Nuclear Division Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Division Regulation Of DNA Replication Protein Heterooligomerization Regulation Of Lipid Biosynthetic Process Phosphatidylinositol-mediated Signaling Positive Regulation Of DNA Metabolic Process Digestive System Development Insulin Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Gland Morphogenesis Regulation Of JNK Cascade Mammary Gland Development Establishment Or Maintenance Of Cell Polarity Regulation Of Stress-activated MAPK Cascade
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	agonistic analogues antagonistic antagonists bu continuing couplings dehydrophenylalanine deltaphe dipeptide dphe fluorine fmoc gives gly guinea ileum iodine kh mtr phe pig position pybop radioligand replacement resin substitutions wang
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	agonistic analogues antagonistic antagonists bu continuing couplings dehydrophenylalanine deltaphe dipeptide dphe fluorine fmoc gives gly guinea ileum iodine kh mtr phe pig position pybop radioligand replacement resin substitutions wang
Tagcloud (Intersection) ?