CBX1 and HECW2

Number of citations of the paper that reports this interaction (PubMedID 30208514)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CBX1	HECW2
Description		chromobox 1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Heterochromatin Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Pericentric Heterochromatin Spindle Chromocenter Nuclear Body Site Of DNA Damage	Cytoplasm Spindle Cytoskeleton Mitotic Spindle
	Molecular Function	Chromatin Binding Protein Binding Enzyme Binding Identical Protein Binding Histone Methyltransferase Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Dendrite Morphogenesis
Pathways		HCMV Early Events	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Body mass index ( 20935630 26426971) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Generalized epilepsy ( 22949513)	Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Response to fenofibrate (LDL cholesterol levels) ( 27002377)
Interacting Genes		34 interacting genes: ABI3BP ARL5A ATXN7L2 BAHD1 BARD1 BRCA1 CBX3 CBX5 CHAF1A DNMT1 DNMT3A DNMT3B EMSY H1-4 H3-4 H3C1 H3C3 HECW2 HSPB1 KLF11 LNX1 LRIF1 NR2F6 PCNA PIM1 RPL12 SP100 SUV39H1 TRIM24 TRIM28 UCHL1 VHL VTN ZNF280C	8 interacting genes: CBX1 CBX3 CBX5 FZR1 TP73 UBE2D2 UBE2D3 UBE2L3
Entrez ID		10951	57520
HPRD ID		05149	17099
Ensembl ID		ENSG00000108468	ENSG00000138411
Uniprot IDs		P83916 Q6IBN6	A0A2R8Y6F3 Q9P2P5
PDB IDs		2FMM 3F2U 3Q6S 5T1G 6D07 6D08	2LFE
Enriched GO Terms of Interacting Partners?		Chromatin Organization Heterochromatin Chromatin Remodeling Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA (cytosine-5-)-methyltransferase Activity Nucleoplasm Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Euchromatin Chromo Shadow Domain Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Programming Of Gene Expression Negative Regulation Of Biosynthetic Process Ubiquitin-protein Transferase Activity Chromosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region Regulation Of Primary Metabolic Process DNA Damage Response Nucleosome Assembly Histone H2AK127 Ubiquitin Ligase Activity Nucleus Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Macromolecule Metabolic Process BRCA1-BARD1 Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Metabolic Process Nucleosome Organization DNA Binding Cellular Response To Stress DNA-methyltransferase Activity BRCA1-B Complex Cellular Response To Bisphenol A Structural Constituent Of Chromatin Pericentric Heterochromatin Post-translational Protein Modification Protein-DNA Complex Assembly	DNA Damage Response Ubiquitin Conjugating Enzyme Activity Pericentric Heterochromatin Protein K11-linked Ubiquitination Site Of DNA Damage Heterochromatin Protein Polyubiquitination Ubiquitin-protein Transferase Activator Activity Nucleoplasm Chromocenter Cellular Response To Stress Histone Methyltransferase Binding Heterochromatin Formation Chromosome, Centromeric Region Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Regulation Of Protein Targeting To Mitochondrion Epigenetic Regulation Of Gene Expression Cellular Response To Glucocorticoid Stimulus Post-translational Protein Modification Nucleus Cellular Response To Corticosteroid Stimulus Protein Autoubiquitination Enzyme Binding Cellular Response To Steroid Hormone Stimulus Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Macromolecule Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Primary Metabolic Process Positive Regulation Of Lung Ciliated Cell Differentiation Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Chromatin Binding Regulation Of RNA Metabolic Process Proteolysis DNA Repair Chromatin Lock Complex DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Post-translational Protein Modification Response To Glucocorticoid
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?