CBX1 and HIST1H1E

Number of citations of the paper that reports this interaction (PMID 16127177)
54

Data Source:
HPRD (in vitro)

		CBX1	HIST1H1E
Gene Name		chromobox homolog 1	histone cluster 1, H1e
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Female Pronucleus Male Pronucleus Nucleoplasm Nuclear Heterochromatin Pericentric Heterochromatin Spindle Chromocenter	Nucleosome Nucleus Nuclear Heterochromatin Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Protein Binding Enzyme Binding Protein Homodimerization Activity Histone Methyltransferase Binding	Protein Binding Chromatin DNA Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription, DNA-templated	Nucleosome Assembly Nucleosome Positioning
Pathways			DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Body mass index ( 20935630) Epilepsy (generalized) ( 22949513)
Protein-Protein Interactions		29 interactors: ABI3BP ARL5A C11orf30 CBX3 CBX5 CHAF1A DNMT1 DNMT3A DNMT3B EHMT2 HIST1H1E HIST1H3A HIST1H3C HIST3H3 KLF11 LRIF1 NR2F6 NSL1 PCNA PIM1 RB1 RPL12 SP100 SUV39H1 TRIM24 TRIM28 UCHL1 VHL VTN	6 interactors: CBX1 CBX3 CBX5 IL7R IRAK4 PRKCA
Entrez ID		10951	3008
HPRD ID		05149	07513
Ensembl ID		ENSG00000108468	ENSG00000168298
Uniprot IDs		P83916 Q6IBN6	A3R0T8 P10412
PDB IDs		2FMM 3F2U 3Q6S	3TZD
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Methylation Negative Regulation Of Cellular Metabolic Process DNA Modification Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process Chromatin Silencing Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification DNA Metabolic Process Gene Silencing Regulation Of Gene Expression DNA Methylation On Cytosine Within A CG Sequence C-5 Methylation Of Cytosine Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Methylation Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Organelle Organization Regulation Of Metabolic Process DNA Replication-dependent Nucleosome Assembly Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA RNA Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle S-adenosylmethioninamine Metabolic Process RNA Metabolic Process Transcription, DNA-templated Cellular Metabolic Process Nucleosome Assembly DNA Methylation Involved In Embryo Development S-adenosylhomocysteine Metabolic Process Chromatin Assembly Cellular Macromolecule Biosynthetic Process Nucleosome Organization	Negative Regulation Of Biosynthetic Process Positive Regulation Of Dense Core Granule Biogenesis Response To Cytokine Interleukin-7-mediated Signaling Pathway Histone H3-T6 Phosphorylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of T Cell Mediated Cytotoxicity Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Glucose Import Immune Response Regulation Of Immune System Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Gene Expression Desmosome Organization Negative Regulation Of T Cell Mediated Immunity Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Blood Coagulation Hemostasis Positive Regulation Of Blood Vessel Endothelial Cell Migration Cytokine-mediated Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Regulation Of Cell Activation Negative Regulation Of Lyase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Rhodopsin Mediated Signaling Pathway Regulation Of Platelet Activation Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Cellular Response To Organic Substance
Tagcloud ?		apobec3 ash2l cbx3 cbx5 cbx6 cbx7 chd3 chd4 dek dnmt3b hdac7 ino80e kat1 kdm1b kdm2b kdm5c kdm7 modifiers ncoa4 ontogenic ontogeny prmt1 prmt7 setd8 smarca2 smarca4 smarcb1 suv420h2 unveils	abundance arrest bax bcl beneficial calcitriol candidates changing cyclins d3 eif2ak2 endometrial g0 hint2 identifies immortalized investigates oncogenesis p27 preventing progesterone proteomics prove stranded triad upregulate validation
Tagcloud (Difference) ?		apobec3 ash2l cbx3 cbx5 cbx6 cbx7 chd3 chd4 dek dnmt3b hdac7 ino80e kat1 kdm1b kdm2b kdm5c kdm7 modifiers ncoa4 ontogenic ontogeny prmt1 prmt7 setd8 smarca2 smarca4 smarcb1 suv420h2 unveils	abundance arrest bax bcl beneficial calcitriol candidates changing cyclins d3 eif2ak2 endometrial g0 hint2 identifies immortalized investigates oncogenesis p27 preventing progesterone proteomics prove stranded triad upregulate validation
Tagcloud (Intersection) ?