CBX1 and CBX5

Number of citations of the paper that reports this interaction (PMID 11336697)
99

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		CBX1	CBX5
Gene Name		chromobox homolog 1	chromobox homolog 5
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Female Pronucleus Male Pronucleus Nucleoplasm Nuclear Heterochromatin Pericentric Heterochromatin Spindle Chromocenter	Histone Deacetylase Complex Kinetochore Nucleus Nuclear Envelope Nucleoplasm Nuclear Heterochromatin Nucleolus Chromocenter PML Body Transcriptional Repressor Complex Nuclear Pericentric Heterochromatin Histone Methyltransferase Complex
	Molecular Function	Chromatin Binding Protein Binding Enzyme Binding Protein Homodimerization Activity Histone Methyltransferase Binding	Chromatin Binding Protein Binding Protein Binding, Bridging Methylated Histone Binding Protein Homodimerization Activity Histone Deacetylase Binding Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription, DNA-templated	Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Body mass index ( 20935630) Epilepsy (generalized) ( 22949513)	Mean platelet volume ( 22139419)
Protein-Protein Interactions		29 interactors: ABI3BP ARL5A C11orf30 CBX3 CBX5 CHAF1A DNMT1 DNMT3A DNMT3B EHMT2 HIST1H1E HIST1H3A HIST1H3C HIST3H3 KLF11 LRIF1 NR2F6 NSL1 PCNA PIM1 RB1 RPL12 SP100 SUV39H1 TRIM24 TRIM28 UCHL1 VHL VTN	50 interactors: ARHGDIA ARL5A BCL11B CBX1 CBX3 CHAF1A DNMT3B DSN1 FSHR GOLGA8EP HDAC4 HDAC5 HDAC9 HIST1H1B HIST1H1E HIST2H3A HIST3H2A HIST3H2BB HIST3H3 HIST4H4 INCENP LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 SUV39H2 TAF4 TCEB1 TCEB3B TRIM24 TRIM28 VPS28 WHSC1L1 XRCC6 XRN1
Entrez ID		10951	23468
HPRD ID		05149	05131
Ensembl ID		ENSG00000108468	ENSG00000094916
Uniprot IDs		P83916 Q6IBN6	P45973
PDB IDs		2FMM 3F2U 3Q6S	3FDT 3I3C
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Methylation Negative Regulation Of Cellular Metabolic Process DNA Modification Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process Chromatin Silencing Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification DNA Metabolic Process Gene Silencing Regulation Of Gene Expression DNA Methylation On Cytosine Within A CG Sequence C-5 Methylation Of Cytosine Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Methylation Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Organelle Organization Regulation Of Metabolic Process DNA Replication-dependent Nucleosome Assembly Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA RNA Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle S-adenosylmethioninamine Metabolic Process RNA Metabolic Process Transcription, DNA-templated Cellular Metabolic Process Nucleosome Assembly DNA Methylation Involved In Embryo Development S-adenosylhomocysteine Metabolic Process Chromatin Assembly Cellular Macromolecule Biosynthetic Process Nucleosome Organization	Chromosome Organization Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Silencing Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Modification Regulation Of Gene Expression, Epigenetic Histone H3-K9 Modification Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Positive Regulation Of Gene Expression Chromatin Assembly Or Disassembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Gene Silencing Histone Modification Cellular Macromolecule Biosynthetic Process Chromatin Remodeling Macromolecule Biosynthetic Process DNA Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Nucleosome Organization Regulation Of Metabolic Process DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter DNA Modification
Tagcloud ?		apobec3 ash2l cbx3 cbx5 cbx6 cbx7 chd3 chd4 dek dnmt3b hdac7 ino80e kat1 kdm1b kdm2b kdm5c kdm7 modifiers ncoa4 ontogenic ontogeny prmt1 prmt7 setd8 smarca2 smarca4 smarcb1 suv420h2 unveils	1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri
Tagcloud (Difference) ?		apobec3 ash2l cbx3 cbx6 cbx7 chd3 chd4 dek dnmt3b hdac7 ino80e kat1 kdm1b kdm2b kdm5c kdm7 modifiers ncoa4 ontogenic ontogeny prmt1 prmt7 setd8 smarca2 smarca4 smarcb1 suv420h2 unveils	1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri
Tagcloud (Intersection) ?		cbx5