SDC2 and ANOS1

Number of citations of the paper that reports this interaction (PubMedID 8832397)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SDC2	ANOS1
Description		syndecan 2	anosmin 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix Lysosomal Lumen	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Extracellular Matrix
	Molecular Function	Protein Binding PDZ Domain Binding Identical Protein Binding	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Peptidase Inhibitor Activity
	Biological Process	Nervous System Development Cell Migration Cell Differentiation Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis	Chemotaxis Cell Adhesion Axon Guidance Neuron Differentiation
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	FGFR1c ligand binding and activation Negative regulation of FGFR1 signaling
Drugs		Sargramostim
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		29 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4 UBC	6 interacting genes: FGFR2 FGFR3 FN1 NCALD SDC2 UBQLN1
Entrez ID		6383	3730
HPRD ID		00803	02393
Ensembl ID		ENSG00000169439	ENSG00000011201
Uniprot IDs		E9PBI9 P34741	P23352
PDB IDs		6ITH	1ZLG
Enriched GO Terms of Interacting Partners?		Extracellular Space Regulation Of Multicellular Organismal Process Platelet Alpha Granule Lumen Extracellular Region Regulation Of Developmental Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Regulation Of MAPK Cascade Regulation Of Wound Healing Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Development Heparin Binding Signaling Receptor Binding Positive Regulation Of Gene Expression Extracellular Matrix Regulation Of Response To Wounding Basement Membrane Signal Transduction Regulation Of Endothelial Cell Migration Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Vasculature Development Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Anatomical Structure Morphogenesis Plasma Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macrophage Differentiation Regulation Of Vesicle-mediated Transport Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Signal Transduction	Positive Regulation Of Phospholipase Activity Fibroblast Growth Factor Receptor Activity Positive Regulation Of Lipase Activity Endochondral Bone Growth Bone Growth Fibroblast Growth Factor Binding Bone Morphogenesis Identical Protein Binding Regulation Of ERK1 And ERK2 Cascade Regulation Of Developmental Growth Organ Growth Transmembrane Receptor Protein Tyrosine Kinase Activity Bone Mineralization Fibroblast Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Negative Regulation Of Store-operated Calcium Channel Activity Biomineral Tissue Development Regulation Of Signal Transduction Regulation Of Growth Positive Regulation Of Hydrolase Activity Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Bone Maturation Regulation Of Protein Modification Process Regulation Of MAPK Cascade Cell Surface Protein Tyrosine Kinase Activity Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Ventricular Zone Neuroblast Division Cellular Response To Decreased Oxygen Levels Prostate Epithelial Cord Elongation Cellular Response To Hypoxia Orbitofrontal Cortex Development Mammary Gland Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Branch Elongation Involved In Salivary Gland Morphogenesis Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Heparin Binding Cellular Response To Oxygen Levels Positive Regulation Of Developmental Growth Calcium-independent Cell-matrix Adhesion Regulation Of Cell Communication Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Signaling Prostate Gland Morphogenesis
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