SDC2 and REG3A

Number of citations of the paper that reports this interaction (PubMedID 8997243)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SDC2	REG3A
Description		syndecan 2	regenerating family member 3 alpha
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix Lysosomal Lumen	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Protein Binding PDZ Domain Binding Identical Protein Binding	Hormone Activity Protein Binding Carbohydrate Binding Signaling Receptor Activity Identical Protein Binding Peptidoglycan Binding Oligosaccharide Binding
	Biological Process	Nervous System Development Cell Migration Cell Differentiation Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis	Acute-phase Response Inflammatory Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Population Proliferation Response To Symbiotic Bacterium Response To Wounding Positive Regulation Of Keratinocyte Proliferation Response To Peptide Hormone Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Wound Healing Inflammatory Response To Wounding Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Detection Of Glucose
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	Antimicrobial peptides
Drugs		Sargramostim
Diseases
GWAS		Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)	Body mass index ( 25673413) HDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		29 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4 UBC	6 interacting genes: ANXA3 FN1 MDFI REG1A SDC2 TRHDE
Entrez ID		6383	5068
HPRD ID		00803	01342
Ensembl ID		ENSG00000169439	ENSG00000172016
Uniprot IDs		E9PBI9 P34741	Q06141 Q53S56
PDB IDs		6ITH	1UV0 2GO0 4MTH
Enriched GO Terms of Interacting Partners?		Extracellular Space Regulation Of Multicellular Organismal Process Platelet Alpha Granule Lumen Extracellular Region Regulation Of Developmental Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Regulation Of MAPK Cascade Regulation Of Wound Healing Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Development Heparin Binding Signaling Receptor Binding Positive Regulation Of Gene Expression Extracellular Matrix Regulation Of Response To Wounding Basement Membrane Signal Transduction Regulation Of Endothelial Cell Migration Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Vasculature Development Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Anatomical Structure Morphogenesis Plasma Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macrophage Differentiation Regulation Of Vesicle-mediated Transport Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Signal Transduction
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