SDC2 and TNFSF13

Number of citations of the paper that reports this interaction (PubMedID 15846369)
0

Data Source:
HPRD (in vivo)

		SDC2	TNFSF13
Description		syndecan 2	TNF superfamily member 13
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix Lysosomal Lumen	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Protein Binding PDZ Domain Binding Identical Protein Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Nervous System Development Cell Migration Cell Differentiation Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis	Lymphocyte Homeostasis Immune System Process Immune Response Cell Communication Signal Transduction Positive Regulation Of Cell Population Proliferation Signaling Positive Regulation Of B Cell Proliferation Positive Regulation Of Isotype Switching To IgA Isotypes
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	HuR (ELAVL1) binds and stabilizes mRNA TNFs bind their physiological receptors
Drugs		Sargramostim
Diseases
GWAS		Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)	Albumin-globulin ratio ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) IgA levels ( 28628107 22864923) IgA nephropathy ( 22197929 26028593 25305756) IgM levels ( 23118916) Myopia ( 27182965) Non-albumin protein levels ( 29403010 22558069) Serum total protein levels ( 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		29 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4 UBC	13 interacting genes: CAMK1D FAS FURIN KRAS PIK3CA SDC2 SGTB TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B
Entrez ID		6383	8741
HPRD ID		00803	05128
Ensembl ID		ENSG00000169439	ENSG00000161955
Uniprot IDs		E9PBI9 P34741	O75888 Q2QBA2
PDB IDs		6ITH	4ZCH
Enriched GO Terms of Interacting Partners?		Extracellular Space Regulation Of Multicellular Organismal Process Platelet Alpha Granule Lumen Extracellular Region Regulation Of Developmental Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Regulation Of MAPK Cascade Regulation Of Wound Healing Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Development Heparin Binding Signaling Receptor Binding Positive Regulation Of Gene Expression Extracellular Matrix Regulation Of Response To Wounding Basement Membrane Signal Transduction Regulation Of Endothelial Cell Migration Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Vasculature Development Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Anatomical Structure Morphogenesis Plasma Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macrophage Differentiation Regulation Of Vesicle-mediated Transport Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Signal Transduction	Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Receptor Activity Cytokine-mediated Signaling Pathway Signaling Receptor Activity Cell Surface Receptor Signaling Pathway Signal Transduction Homeostasis Of Number Of Cells Lymphocyte Homeostasis Heparan Sulfate Binding Plasma Membrane Multicellular Organismal-level Homeostasis Leukocyte Homeostasis Adaptive Immune Response Regulation Of Immune System Process B Cell Homeostasis Response To Mechanical Stimulus Cell Death Membrane Raft Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Process Programmed Cell Death Regulation Of Multicellular Organismal Process Negative Regulation Of Immune System Process T Cell Costimulation Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Regulation Of Mononuclear Cell Proliferation Regulation Of Developmental Process Immune Response Cellular Response To Mechanical Stimulus Immune System Process Cell Surface Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Multicellular Organismal Process Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Negative Regulation Of Adaptive Immune Memory Response Regulation Of Leukocyte Proliferation Positive Regulation Of Germinal Center Formation Regulation Of B Cell Proliferation Transitional One Stage B Cell Differentiation TRC Complex Homeostatic Process Fas Signaling Pathway GMP Binding
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