SDC2 and CYP2C18

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SDC2	CYP2C18
Description		syndecan 2	cytochrome P450 family 2 subfamily C member 18
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix Lysosomal Lumen	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding PDZ Domain Binding Identical Protein Binding	Monooxygenase Activity Iron Ion Binding Arachidonate Epoxygenase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Metal Ion Binding Linoleic Acid Epoxygenase Activity
	Biological Process	Nervous System Development Cell Migration Cell Differentiation Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis	Lipid Metabolic Process Terpenoid Metabolic Process Xenobiotic Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Linoleic Acid Metabolic Process
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	Xenobiotics
Drugs		Sargramostim	N,4-Dimethyl-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
Diseases
GWAS		Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)	Acenocoumarol maintenance dosage ( 19578179) Clopidogrel active metabolite levels ( 28207573) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Red cell distribution width ( 32888494) Response to clopidogrel therapy ( 19706858 28207573) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 23093944) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose ( 23755828) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		29 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4 UBC	5 interacting genes: A2M APOE ECSIT PSEN1 SDC2
Entrez ID		6383	1562
HPRD ID		00803	03085
Ensembl ID		ENSG00000169439	ENSG00000108242
Uniprot IDs		E9PBI9 P34741	P33260
PDB IDs		6ITH	2CIK 2H6P
Enriched GO Terms of Interacting Partners?		Extracellular Space Regulation Of Multicellular Organismal Process Platelet Alpha Granule Lumen Extracellular Region Regulation Of Developmental Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Regulation Of MAPK Cascade Regulation Of Wound Healing Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Development Heparin Binding Signaling Receptor Binding Positive Regulation Of Gene Expression Extracellular Matrix Regulation Of Response To Wounding Basement Membrane Signal Transduction Regulation Of Endothelial Cell Migration Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Vasculature Development Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Anatomical Structure Morphogenesis Plasma Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macrophage Differentiation Regulation Of Vesicle-mediated Transport Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Signal Transduction	Positive Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Amyloid Precursor Protein Metabolic Process Enzyme Binding Regulation Of Immune Response Regulation Of Innate Immune Response Extracellular Matrix Negative Regulation Of Phospholipid Efflux Maintenance Of Location Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Response To Amyloid-beta Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Maintenance Of Location In Cell Positive Regulation Of Dendritic Spine Development Cellular Response To Amyloid-beta Regulation Of Dendritic Spine Development Regulation Of Neuron Projection Development Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Negative Regulation Of Core Promoter Binding PDZ Domain Binding Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Set3 Complex Rpd3L-Expanded Complex Blood Microparticle Memory Negative Regulation Of Neuron Projection Development Myeloid Leukocyte Activation Interleukin-8 Binding Regulation Of Immune System Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Postsynapse Organization Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cell Projection Organization Blood Vessel Development Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Phospholipid Efflux
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