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SUFU and ZNF446
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
SUFU
ZNF446
Gene Name
suppressor of fused homolog (Drosophila)
zinc finger protein 446
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Primary Cilium
Ciliary Tip
Ciliary Base
Extracellular Space
Nucleus
Molecular Function
Transcription Corepressor Activity
Signal Transducer Activity
Protein Binding
Beta-catenin Binding
Transcription Factor Binding
Protein Kinase Binding
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
DNA Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Skeletal System Development
Neural Tube Closure
Heart Looping
Regulation Of Transcription, DNA-templated
Proteolysis
Signal Transduction
Multicellular Organismal Development
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification
Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification
Negative Regulation Of Transcription Factor Import Into Nucleus
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Skin Development
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Pathways
Hedgehog 'off' state
Hedgehog 'on' state
Signaling by Hedgehog
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Degradation of GLI2 by the proteasome
Generic Transcription Pathway
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
26 interactors:
BTRC
GLI1
GLI2
GLI3
GLIS3
HDX
HMGA1
HNRNPA1
LAMTOR3
LGALS3
MID1IP1
NCOA3
PEX26
PIAS1
QPRT
RBPJ
RCN3
RNF19A
SAP18
SETDB1
STK36
ZNF219
ZNF263
ZNF446
ZNF747
ZNF764
25 interactors:
ACTN2
DGCR6
DGCR6L
FHL5
KRT40
KRTAP10-3
LZTS2
NOTCH2NL
PGBD1
PIN1
SUFU
TRIM27
ZKSCAN7
ZNF165
ZNF232
ZNF24
ZNF263
ZNF396
ZNF397
ZNF496
ZSCAN16
ZSCAN21
ZSCAN22
ZSCAN32
ZSCAN9
Entrez ID
51684
55663
HPRD ID
06124
07934
Ensembl ID
ENSG00000107882
ENSG00000083838
Uniprot IDs
Q9UMX1
Q9NWS9
PDB IDs
1M1L
Enriched GO Terms of Interacting Partners
?
RNA Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Smoothened Signaling Pathway
Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Nitrogen Compound Metabolic Process
Notochord Regression
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Mammary Gland Morphogenesis
Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification
Tube Morphogenesis
Smoothened Signaling Pathway
Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning
Ventral Midline Development
Gland Development
Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Organ Formation
Proximal/distal Pattern Formation
Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation
Pituitary Gland Development
Gland Morphogenesis
Positive Regulation Of Neural Precursor Cell Proliferation
Mammary Gland Development
Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Gene Expression
RNA Metabolic Process
Regulation Of Metabolic Process
Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Cellular Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Ion Transmembrane Transport
Negative Regulation Of Transmembrane Transport
Negative Regulation Of Interleukin-2 Secretion
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Ion Transport
Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Protein Localization
Negative Regulation Of Transport
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning
Negative Regulation Of Calcium Ion Import
Microspike Assembly
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Negative Regulation Of Protein Localization To Cell Surface
Interferon-gamma Secretion
Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cellular Metabolic Process
Spindle Midzone Assembly
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Tagcloud
?
beta1
blots
cck
colorectal
constructed
counting
enhances
gli1
hedgehog
hh
ht29
infecting
integrin
interference
invasion
itgb1
kit
lentiviral
lentivirus
malignancies
migrating
rnai
shh
sonic
transwell
unrelated
vectors
xenografted
xenografting
Tagcloud (Difference)
?
beta1
blots
cck
colorectal
constructed
counting
enhances
gli1
hedgehog
hh
ht29
infecting
integrin
interference
invasion
itgb1
kit
lentiviral
lentivirus
malignancies
migrating
rnai
shh
sonic
transwell
unrelated
vectors
xenografted
xenografting
Tagcloud (Intersection)
?