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SUFU and STK36
Number of citations of the paper that reports this interaction (PMID
10806483
)
26
Data Source:
HPRD
(in vivo)
SUFU
STK36
Gene Name
suppressor of fused homolog (Drosophila)
serine/threonine kinase 36
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Primary Cilium
Ciliary Tip
Ciliary Base
Nucleus
Cytoplasm
Molecular Function
Transcription Corepressor Activity
Signal Transducer Activity
Protein Binding
Beta-catenin Binding
Transcription Factor Binding
Protein Kinase Binding
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Skeletal System Development
Neural Tube Closure
Heart Looping
Regulation Of Transcription, DNA-templated
Proteolysis
Signal Transduction
Multicellular Organismal Development
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification
Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification
Negative Regulation Of Transcription Factor Import Into Nucleus
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Skin Development
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Epithelial Cilium Movement
Protein Phosphorylation
Positive Regulation Of Hh Target Transcription Factor Activity
Brain Development
Post-embryonic Development
Cilium Assembly
Positive Regulation Of Smoothened Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways
Hedgehog 'off' state
Hedgehog 'on' state
Signaling by Hedgehog
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Amyotrophic lateral sclerosis (
22959728
)
Protein-Protein Interactions
26 interactors:
BTRC
GLI1
GLI2
GLI3
GLIS3
HDX
HMGA1
HNRNPA1
LAMTOR3
LGALS3
MID1IP1
NCOA3
PEX26
PIAS1
QPRT
RBPJ
RCN3
RNF19A
SAP18
SETDB1
STK36
ZNF219
ZNF263
ZNF446
ZNF747
ZNF764
9 interactors:
CDK5RAP2
CDK9
FRMPD4
GLI1
GLI2
GLI3
MAST2
MID1
SUFU
Entrez ID
51684
27148
HPRD ID
06124
09631
Ensembl ID
ENSG00000107882
ENSG00000163482
Uniprot IDs
Q9UMX1
Q9NRP7
PDB IDs
1M1L
Enriched GO Terms of Interacting Partners
?
RNA Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Smoothened Signaling Pathway
Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Nitrogen Compound Metabolic Process
Notochord Regression
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Mammary Gland Morphogenesis
Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification
Tube Morphogenesis
Smoothened Signaling Pathway
Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning
Ventral Midline Development
Gland Development
Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Organ Formation
Proximal/distal Pattern Formation
Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation
Pituitary Gland Development
Gland Morphogenesis
Positive Regulation Of Neural Precursor Cell Proliferation
Mammary Gland Development
Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning
Ventral Spinal Cord Interneuron Specification
Spinal Cord Motor Neuron Cell Fate Specification
Ventral Spinal Cord Interneuron Fate Commitment
Regulation Of Smoothened Signaling Pathway
Ventral Spinal Cord Interneuron Differentiation
Smoothened Signaling Pathway
Dorsal/ventral Pattern Formation
Notochord Regression
Spinal Cord Dorsal/ventral Patterning
Neuron Fate Specification
Spinal Cord Patterning
Pattern Specification Process
Spinal Cord Motor Neuron Differentiation
Proximal/distal Pattern Formation
Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation
Ventral Midline Development
Positive Regulation Of Neural Precursor Cell Proliferation
Ventral Spinal Cord Development
Cell Differentiation In Spinal Cord
Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation
Digestive Tract Morphogenesis
Neuron Fate Commitment
Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Embryonic Organ Morphogenesis
Hindgut Morphogenesis
Notochord Morphogenesis
Cell Fate Specification
Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Hindgut Development
Regulation Of Neural Precursor Cell Proliferation
Spinal Cord Development
Regulation Of DNA Replication
Tube Morphogenesis
Central Nervous System Development
Anatomical Structure Regression
Digestive Tract Development
Digestive System Development
Embryonic Organ Development
Notochord Development
Neural Tube Development
Positive Regulation Of Transcription, DNA-templated
Embryonic Morphogenesis
Central Nervous System Neuron Differentiation
Negative Regulation Of Smoothened Signaling Pathway
Dorsal/ventral Neural Tube Patterning
Tube Development
Lung Development
Tagcloud
?
beta1
blots
cck
colorectal
constructed
counting
enhances
gli1
hedgehog
hh
ht29
infecting
integrin
interference
invasion
itgb1
kit
lentiviral
lentivirus
malignancies
migrating
rnai
shh
sonic
transwell
unrelated
vectors
xenografted
xenografting
Tagcloud (Difference)
?
beta1
blots
cck
colorectal
constructed
counting
enhances
gli1
hedgehog
hh
ht29
infecting
integrin
interference
invasion
itgb1
kit
lentiviral
lentivirus
malignancies
migrating
rnai
shh
sonic
transwell
unrelated
vectors
xenografted
xenografting
Tagcloud (Intersection)
?