SUFU and PEX26

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		SUFU	PEX26
Gene Name		suppressor of fused homolog (Drosophila)	peroxisomal biogenesis factor 26
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Primary Cilium Ciliary Tip Ciliary Base	Peroxisome Integral Component Of Peroxisomal Membrane
	Molecular Function	Transcription Corepressor Activity Signal Transducer Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding	Protein Binding Protein C-terminus Binding Protein Complex Binding ATPase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Neural Tube Closure Heart Looping Regulation Of Transcription, DNA-templated Proteolysis Signal Transduction Multicellular Organismal Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Negative Regulation Of Transcription Factor Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Skin Development Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Membrane
Pathways		Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		26 interactors: BTRC GLI1 GLI2 GLI3 GLIS3 HDX HMGA1 HNRNPA1 LAMTOR3 LGALS3 MID1IP1 NCOA3 PEX26 PIAS1 QPRT RBPJ RCN3 RNF19A SAP18 SETDB1 STK36 ZNF219 ZNF263 ZNF446 ZNF747 ZNF764	4 interactors: PEX1 PEX19 PEX6 SUFU
Entrez ID		51684	55670
HPRD ID		06124	10559
Ensembl ID		ENSG00000107882
Uniprot IDs		Q9UMX1	Q7Z2D7 Q7Z412
PDB IDs		1M1L
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Smoothened Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Notochord Regression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Mammary Gland Morphogenesis Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Tube Morphogenesis Smoothened Signaling Pathway Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Ventral Midline Development Gland Development Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organ Formation Proximal/distal Pattern Formation Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Pituitary Gland Development Gland Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Mammary Gland Development Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation	Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Peroxisome Organization Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Protein Import Protein Import Into Peroxisome Matrix Cellular Protein Localization Establishment Of Protein Localization To Organelle Protein Targeting Protein Localization To Organelle Protein Localization Protein Stabilization Cytoplasmic Transport Cellular Localization Negative Regulation Of Lipid Binding Regulation Of Protein Stability Intracellular Protein Transport Microtubule-based Peroxisome Localization Protein Import Into Peroxisome Matrix, Translocation Peroxisome Membrane Biogenesis Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Protein Transport Establishment Of Protein Localization Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Intracellular Transport Protein Import Into Peroxisome Membrane Chaperone-mediated Protein Transport Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Peroxisomal Membrane Transport Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Transmembrane Transport Peroxisome Fission Posttranscriptional Regulation Of Gene Expression Establishment Of Localization In Cell Ventral Spinal Cord Interneuron Specification Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Fate Commitment Ventral Spinal Cord Interneuron Differentiation Cytoplasmic Sequestering Of Transcription Factor Cytoplasmic Sequestering Of Protein Membrane Biogenesis Negative Regulation Of Embryonic Development Spinal Cord Dorsal/ventral Patterning Neuron Fate Specification Negative Regulation Of Smoothened Signaling Pathway Spinal Cord Patterning Spinal Cord Motor Neuron Differentiation Negative Regulation Of Osteoblast Differentiation
Tagcloud ?		beta1 blots cck colorectal constructed counting enhances gli1 hedgehog hh ht29 infecting integrin interference invasion itgb1 kit lentiviral lentivirus malignancies migrating rnai shh sonic transwell unrelated vectors xenografted xenografting	aberrant accumulate anchored atad1 atpase disruption entry failing get gos1 gos28 guided inserted integrity limits maintain mislocalization mislocalize mislocalized mitochondria mitochondrial msp1 orthologs pex15 subset synergistic ta tail yeast
Tagcloud (Difference) ?		beta1 blots cck colorectal constructed counting enhances gli1 hedgehog hh ht29 infecting integrin interference invasion itgb1 kit lentiviral lentivirus malignancies migrating rnai shh sonic transwell unrelated vectors xenografted xenografting	aberrant accumulate anchored atad1 atpase disruption entry failing get gos1 gos28 guided inserted integrity limits maintain mislocalization mislocalize mislocalized mitochondria mitochondrial msp1 orthologs pex15 subset synergistic ta tail yeast
Tagcloud (Intersection) ?