SUFU

Description		SUFU negative regulator of hedgehog signaling
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Ciliary Tip Ciliary Base GLI-SUFU Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Heart Looping Ventricular Septum Development Regulation Of DNA-templated Transcription Signal Transduction Smoothened Signaling Pathway Spermatid Development Determination Of Left/right Symmetry Spinal Cord Dorsal/ventral Patterning Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Aorta Development Negative Regulation Of Protein Import Into Nucleus Skin Development Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Coronary Vasculature Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Response To Drug
Pathways		Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state
Drugs
Diseases		Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergy ( 27182965) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Creatinine levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Nickel levels ( 26025379) Optic disc size ( 31809533) Platelet count ( 32888494) Prostate cancer ( 23535732) Refractive error ( 32231278) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White blood cell count ( 29403010)
Novel Interacting Genes		2 novel interacting genes: AKR1C1 EDA2R
Interacting Genes		49 interacting genes: ABI3 BFSP2 BTRC CRTC2 CRX DISC1 FBXL17 FXR1 GLI1 GLI2 GLI3 GLIS3 HDX HMGA1 HNRNPA1 ITCH KRT27 KRT75 L3MBTL3 LAMTOR3 LCA5 LGALS3 LZTS1 MAGEL2 MEOX2 MID1IP1 NCOA3 PEX26 PIAS1 QPRT RBPJ RCN3 RNF19A SAP18 SETDB1 SH3RF1 SLC41A3 STK36 STX19 TLE5 TRAF6 ZIC1 ZNF114 ZNF219 ZNF263 ZNF330 ZNF446 ZNF763 ZNF764
Entrez ID		51684
HPRD ID		06124
Ensembl ID		ENSG00000107882
Uniprot IDs		A0A223LX15 Q9UMX1
PDB IDs		1M1L 4BL8 4BL9 4BLA 4BLB 4BLD 4KM8 4KM9 4KMD 4KMH
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding GLI-SUFU Complex Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Smoothened Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Ciliary Base Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nucleus Ventral Midline Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Positive Regulation Of Proteolysis Negative Regulation Of Macromolecule Biosynthetic Process Hindgut Morphogenesis Negative Regulation Of Biosynthetic Process Proximal/distal Pattern Formation Protein K63-linked Ubiquitination RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cerebellar Cortex Morphogenesis Pituitary Gland Development Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Smoothened Signaling Pathway DNA-binding Transcription Factor Activity Negative Regulation Of Metabolic Process Spinal Cord Dorsal/ventral Patterning Cerebral Cortex Radial Glia-guided Migration Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process
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