PALS2 and EXOSC4

Number of citations of the paper that reports this interaction (PubMedID 11719186)
0

Data Source:
HPRD (in vivo)

		PALS2	EXOSC4
Description		protein associated with LIN7 2, MAGUK p55 family member	exosome component 4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Membrane Organelle Extracellular Exosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	Protein Binding	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Protein-containing Complex Assembly	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process Positive Regulation Of Cell Growth U4 SnRNA 3'-end Processing DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS			Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite concentrations in chronic kidney disease ( 33838163)
Interacting Genes		31 interacting genes: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 MTREX NDN NFKB1 OGT PARN RPS20 SMARCA4 SNX9 THOP1 VPS26C WEE2-AS1	34 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LNX1 LRRC8D MPZL1 MTREX NEK1 PALS2 POLE2 PPARA PRRC2B PTEN SDCBP SKIC2 SMPD4 TSEN15 UPF1 UPF2 UPF3B WTAP
Entrez ID		51678	54512
HPRD ID		09509	16221
Ensembl ID		ENSG00000105926	ENSG00000178896
Uniprot IDs		B8ZZG1 Q9NZW5	Q9NPD3
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing MRNA Catabolic Process RNA Catabolic Process Exoribonuclease Complex SnRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process RRNA 3'-end Processing TRNA Decay RRNA Processing RRNA Metabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process RNA Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleolus RNA Metabolic Process CUT Catabolic Process RNA Processing Negative Regulation Of Gene Expression MRNA 3'-UTR AU-rich Region Binding Macromolecule Catabolic Process DNA Deamination Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA Cytoplasm Catabolic Process DNA Modification Negative Regulation Of Macromolecule Metabolic Process	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) RNA Catabolic Process Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nuclear RNA Surveillance Nuclear MRNA Surveillance RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing MRNA Metabolic Process RRNA 3'-end Processing TRNA Decay SnRNA Metabolic Process RNA Metabolic Process Macromolecule Catabolic Process SnRNA 3'-end Processing RRNA Processing 3'-5'-RNA Exonuclease Activity RRNA Metabolic Process SnRNA Processing RNA Binding Nucleic Acid Metabolic Process CUT Catabolic Process RRNA Catabolic Process RNA 3'-end Processing Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Negative Regulation Of Gene Expression RNA Processing Nucleobase-containing Compound Metabolic Process Nucleoplasm Macromolecule Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolus Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Sno(s)RNA Metabolic Process TRNA Metabolic Process Exoribonuclease Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process
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