PALS2 and EXOSC2

Number of citations of the paper that reports this interaction (PubMedID 11719186)
0

Data Source:
HPRD (in vivo)

		PALS2	EXOSC2
Description		protein associated with LIN7 2, MAGUK p55 family member	exosome component 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Membrane Organelle Extracellular Exosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)
	Molecular Function	Protein Binding	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding 7S RNA Binding
	Biological Process	Protein-containing Complex Assembly	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process Positive Regulation Of Cell Growth U4 SnRNA 3'-end Processing CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS
Interacting Genes		31 interacting genes: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 MTREX NDN NFKB1 OGT PARN RPS20 SMARCA4 SNX9 THOP1 VPS26C WEE2-AS1	18 interacting genes: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MRPL48 MTREX PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 ZNF408
Entrez ID		51678	23404
HPRD ID		09509	03758
Ensembl ID		ENSG00000105926	ENSG00000130713
Uniprot IDs		B8ZZG1 Q9NZW5	B3KQW2 Q13868
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing MRNA Catabolic Process RNA Catabolic Process Exoribonuclease Complex SnRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process RRNA 3'-end Processing TRNA Decay RRNA Processing RRNA Metabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process RNA Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleolus RNA Metabolic Process CUT Catabolic Process RNA Processing Negative Regulation Of Gene Expression MRNA 3'-UTR AU-rich Region Binding Macromolecule Catabolic Process DNA Deamination Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA Cytoplasm Catabolic Process DNA Modification Negative Regulation Of Macromolecule Metabolic Process	Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exoribonuclease Complex Nuclear RNA Surveillance RNA Surveillance SnRNA 3'-end Processing SnRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process SnRNA Processing RNA Catabolic Process MRNA Catabolic Process MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity RRNA Processing Nucleobase-containing Compound Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA 3'-end Processing RRNA Metabolic Process MRNA Metabolic Process Macromolecule Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay DNA Deamination Sno(s)RNA Metabolic Process RNA Processing DNA Modification Nucleolus RNA Binding Catabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression Macromolecule Metabolic Process Nucleic Acid Metabolic Process Histone MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Maturation Of 5.8S RRNA Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process
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