MPP6 and THOP1

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		MPP6	THOP1
Gene Name		membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	thimet oligopeptidase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	Protein Binding PDZ Domain Binding	Metalloendopeptidase Activity Protein Binding Peptide Binding Metal Ion Binding
	Biological Process	Protein Complex Assembly	Proteolysis Peptide Metabolic Process Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 NDN NFKB1 PARN RPS20 SKIV2L2 SMARCA4 SNX9 THOP1	6 interactors: AGTR1 CALM1 MPHOSPH6 MPP6 PRKACA TRAF2
Entrez ID		51678	7064
HPRD ID		09509	03072
Ensembl ID		ENSG00000105926	ENSG00000172009
Uniprot IDs		B8ZZG1 Q9NZW5	P52888
PDB IDs			1S4B 2O36
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis RRNA Processing RRNA Metabolic Process Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process Nuclear MRNA Surveillance NcRNA Metabolic Process RNA Surveillance RRNA Catabolic Process Cellular Macromolecule Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Maturation Of 5.8S RRNA Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Gene Expression RNA Metabolic Process DNA Deamination Catabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Growth Histone MRNA Catabolic Process Regulation Of Growth Intracellular MRNA Localization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein-lipid Complex Assembly Histone MRNA Metabolic Process Membrane Organization Positive Regulation Of Cell Growth Cellular Process RNA Processing Cellular Metabolic Process Regulation Of Cholesterol Transport Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Interleukin-12 Biosynthetic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Neurotrophin TRK Receptor Signaling Pathway	Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Lipase Activity Calcium-mediated Signaling Second-messenger-mediated Signaling Regulation Of Ion Homeostasis Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Maturation Of 5.8S RRNA Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of Lyase Activity Activation Of Phospholipase C Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cyclase Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of Oxidoreductase Activity Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Phototransduction, Visible Light Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Kinase Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Striated Muscle Contraction Regulation Of CAMP Biosynthetic Process Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Positive Regulation Of Catalytic Activity Positive Regulation Of Inflammatory Response Positive Regulation Of Transferase Activity Renal System Process Positive Regulation Of Dense Core Granule Biogenesis Phospholipase C-activating Angiotensin-activated Signaling Pathway
Tagcloud ?		binds cofactor cofactors composite conserved core create crystallographic disrupts exo exoribonuclease exosome functionally gfp groove helicase insight interface intertwined mtr4 physically revealing ribonuclease rnas rrp47 rrp6 structural synergize turnover	adjacent array arrays assessing biomarker cirrhosis cn considering correlations gapdh hcc hepatitis hepatocellular insufficient intrahepatic liver matching multicentric nonneoplastic oligopeptidase prediction profiling recurs resected sn supernormal termed thimet transcriptase
Tagcloud (Difference) ?		binds cofactor cofactors composite conserved core create crystallographic disrupts exo exoribonuclease exosome functionally gfp groove helicase insight interface intertwined mtr4 physically revealing ribonuclease rnas rrp47 rrp6 structural synergize turnover	adjacent array arrays assessing biomarker cirrhosis cn considering correlations gapdh hcc hepatitis hepatocellular insufficient intrahepatic liver matching multicentric nonneoplastic oligopeptidase prediction profiling recurs resected sn supernormal termed thimet transcriptase
Tagcloud (Intersection) ?