PALS2 and DIS3

Number of citations of the paper that reports this interaction (PubMedID 11719186)
0

Data Source:
HPRD (in vivo)

		PALS2	DIS3
Description		protein associated with LIN7 2, MAGUK p55 family member	DIS3 exosome endoribonuclease and 3''-5'' exoribonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Membrane Organelle Extracellular Exosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding	3'-5'-RNA Exonuclease Activity RNA Binding Nuclease Activity Endonuclease Activity Exonuclease Activity RNA Nuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Hydrolase Activity
	Biological Process	Protein-containing Complex Assembly	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process Nuclear MRNA Surveillance Of MRNA 3'-end Processing CUT Catabolic Process
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS			Restless legs syndrome ( 29029846)
Interacting Genes		31 interacting genes: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 MTREX NDN NFKB1 OGT PARN RPS20 SMARCA4 SNX9 THOP1 VPS26C WEE2-AS1	13 interacting genes: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MTREX NTMT1 PALS2 RNF10 ZBTB17
Entrez ID		51678	22894
HPRD ID		09509	06338
Ensembl ID		ENSG00000105926	ENSG00000083520
Uniprot IDs		B8ZZG1 Q9NZW5	G3V1J5 Q9Y2L1
PDB IDs			6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing MRNA Catabolic Process RNA Catabolic Process Exoribonuclease Complex SnRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process RRNA 3'-end Processing TRNA Decay RRNA Processing RRNA Metabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process RNA Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleolus RNA Metabolic Process CUT Catabolic Process RNA Processing Negative Regulation Of Gene Expression MRNA 3'-UTR AU-rich Region Binding Macromolecule Catabolic Process DNA Deamination Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA Cytoplasm Catabolic Process DNA Modification Negative Regulation Of Macromolecule Metabolic Process	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance SnRNA Metabolic Process Nuclear RNA Surveillance RNA Surveillance SnRNA 3'-end Processing SnRNA Processing RNA 3'-end Processing RRNA Catabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance RNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Nuclear-transcribed MRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process RRNA Processing Poly(A)-dependent SnoRNA 3'-end Processing MRNA Catabolic Process RRNA Metabolic Process RRNA 3'-end Processing 3'-5'-RNA Exonuclease Activity TRNA Decay Nucleobase-containing Compound Catabolic Process Sno(s)RNA Metabolic Process MRNA Metabolic Process Macromolecule Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA Processing Nucleolus MRNA 3'-UTR AU-rich Region Binding Catabolic Process DNA Deamination RNA Metabolic Process RNA Binding TRNA Metabolic Process Negative Regulation Of Gene Expression Maturation Of 5.8S RRNA DNA Modification Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process SnRNA Catabolic Process
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