MPP6 and PARN

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		MPP6	PARN
Gene Name		membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	poly(A)-specific ribonuclease
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Vesicular Exosome	Nucleus Nucleolus Cytoplasm Cytosol
	Molecular Function	Protein Binding PDZ Domain Binding	Nucleotide Binding MRNA 3'-UTR Binding Nuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Protein Kinase Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Protein Complex Assembly	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Female Gamete Generation RNA Modification Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA KSRP destabilizes mRNA ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 NDN NFKB1 PARN RPS20 SKIV2L2 SMARCA4 SNX9 THOP1	5 interactors: KHSRP MAPKAPK2 MPHOSPH6 MPP6 SPATC1L
Entrez ID		51678	5073
HPRD ID		09509	07250
Ensembl ID		ENSG00000105926	ENSG00000140694
Uniprot IDs		B8ZZG1 Q9NZW5	B3KN69 B4DSB0 O95453
PDB IDs			2A1R 2A1S 3CTR
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis RRNA Processing RRNA Metabolic Process Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process Nuclear MRNA Surveillance NcRNA Metabolic Process RNA Surveillance RRNA Catabolic Process Cellular Macromolecule Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Maturation Of 5.8S RRNA Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Gene Expression RNA Metabolic Process DNA Deamination Catabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Growth Histone MRNA Catabolic Process Regulation Of Growth Intracellular MRNA Localization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein-lipid Complex Assembly Histone MRNA Metabolic Process Membrane Organization Positive Regulation Of Cell Growth Cellular Process RNA Processing Cellular Metabolic Process Regulation Of Cholesterol Transport Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Interleukin-12 Biosynthetic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Neurotrophin TRK Receptor Signaling Pathway	Maturation Of 5.8S RRNA RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Macropinocytosis Ribonucleoprotein Complex Biogenesis Regulation Of MiRNA Metabolic Process 3'-UTR-mediated MRNA Stabilization
Tagcloud ?		binds cofactor cofactors composite conserved core create crystallographic disrupts exo exoribonuclease exosome functionally gfp groove helicase insight interface intertwined mtr4 physically revealing ribonuclease rnas rrp47 rrp6 structural synergize turnover	ags arrested bulk deadenylases deadenylation decay deciphered depletion dissimilar g0 gastric heterogeneity knocking limiting mkn28 motility mrnas p21 p27 relied ribonuclease silence stability stabilizing stably triggered unaffected upregulating utr
Tagcloud (Difference) ?		binds cofactor cofactors composite conserved core create crystallographic disrupts exo exoribonuclease exosome functionally gfp groove helicase insight interface intertwined mtr4 physically revealing rnas rrp47 rrp6 structural synergize turnover	ags arrested bulk deadenylases deadenylation decay deciphered depletion dissimilar g0 gastric heterogeneity knocking limiting mkn28 motility mrnas p21 p27 relied silence stability stabilizing stably triggered unaffected upregulating utr
Tagcloud (Intersection) ?		ribonuclease