PPIL1 and WDR77

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid)

		PPIL1	WDR77
Description		peptidylprolyl isomerase like 1	WD repeat domain 77
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cul4B-RING E3 Ubiquitin Ligase Complex Methylosome Transferase Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity Disordered Domain Specific Binding	Transcription Coactivator Activity Protein Binding Methyl-CpG Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization MRNA Processing Protein Folding RNA Splicing Embryonic Brain Development	Protein Polyubiquitination Spliceosomal SnRNP Assembly Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Oocyte Axis Specification Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways		mRNA Splicing - Major Pathway	snRNP Assembly RMTs methylate histone arginines
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Blood protein levels ( 30072576) Heart rate ( 28610988) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Resting heart rate ( 27798624) Weight ( 28552196)
Interacting Genes		25 interacting genes: COL17A1 CPSF6 DDIT4L GADD45G HNRNPA1 HNRNPUL1 KPRP LHX2 LNX2 N4BP2L2 POU6F2 PPP1R8 PRR22 PRR35 RBM42 RIMBP3 SF3B3 SNW1 SPDYE4 SRPK1 SRPK2 TCF4 THOC5 UFL1 WDR77	46 interacting genes: AQR BAG2 CDK19 CDK8 CLNS1A CREBBP CTDP1 EIF4A1 GLI1 GPKOW H2AC21 HNRNPM LSM3 NKX3-1 PCBP2 PDCD4 PPIL1 PPP1R8 PQBP1 PRKG1 PRKG2 PRMT5 QKI RBM5 SAP30BP SF1 SF3A1 SF3B4 SIRT7 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 UBC YWHAB YWHAQ ZMYND19 ZNF207
Entrez ID		51645	79084
HPRD ID		03194	14387
Ensembl ID		ENSG00000137168	ENSG00000116455
Uniprot IDs		Q9Y3C6	A0A024R0H7 Q9BQA1
PDB IDs		1XWN 2K7N 2X7K 5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P 7BO7 7KIB 7KIC 7KID 7L1G 7M05 7MX7 7MXA 7MXC 7MXG 7MXN 7S0U 7S1P 7S1Q 7S1R 7S1S 7SER 7SES 7U30 7UOH 7UY1 7UYF 7ZUP 7ZUQ 7ZUU 7ZUY 7ZV2 7ZVL 7ZVU 8CSG 8CTB 8CYI 8G1U 8VEO 8VET 8VEU 8VEW 8VEX 8VEY 8X6L 9C10 9DOD 9E3A 9E3B 9EYU 9EYV 9EYW 9EYX 9MGL 9MGM 9MGN 9MGP 9MGQ 9MGR 9N3N 9N3O 9N3P 9N3Q 9N3R
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing Regulation Of RNA Splicing MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Processing Spliceosomal Complex Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Spliceosomal Complex Assembly Nucleic Acid Metabolic Process RNA Binding Protein-RNA Complex Assembly Catalytic Step 2 Spliceosome Nuclear Speck Nucleobase-containing Compound Metabolic Process Nucleus MRNA Binding Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Viral Genome Replication Cell Differentiation Ribonuclease E Activity Exon-exon Junction Complex Binding UFM1 Ligase Activity Oocyte Axis Specification Regulation Of RNA Metabolic Process Protein-containing Complex Assembly Positive Regulation Of RNA Splicing Negative Regulation Of Viral Genome Replication	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Splicing MRNA Processing MRNA Metabolic Process Methylosome RNA Processing RNA Metabolic Process Spliceosomal Complex Assembly PICln-Sm Protein Complex Catalytic Step 2 Spliceosome U2-type Prespliceosome Assembly Spliceosomal SnRNP Assembly U2 SnRNP Protein-RNA Complex Assembly Nucleic Acid Metabolic Process U2-type Spliceosomal Complex RNA Binding 7-methylguanosine Cap Hypermethylation U2-type Catalytic Step 2 Spliceosome U2-type Precatalytic Spliceosome Nucleoplasm U1 SnRNP Nucleus U4 SnRNP U12-type Spliceosomal Complex Nucleobase-containing Compound Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Precatalytic Spliceosome U5 SnRNP U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process U7 SnRNP Ribonucleoprotein Complex MRNA Binding Macromolecule Methylation Methylation RNA Methylation Commitment Complex Protein-containing Complex Assembly Nucleic Acid Binding Protein-containing Complex Organization RNA Modification CGMP-dependent Protein Kinase Activity MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Telomerase Holoenzyme Complex Histone Pre-mRNA DCP Binding
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