PPIL1 and PRR22

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PPIL1	PRR22
Description		peptidylprolyl isomerase like 1	proline rich 22
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity Disordered Domain Specific Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization MRNA Processing Protein Folding RNA Splicing Embryonic Brain Development
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Blood protein levels ( 30072576) Heart rate ( 28610988) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Resting heart rate ( 27798624) Weight ( 28552196)
Interacting Genes		25 interacting genes: COL17A1 CPSF6 DDIT4L GADD45G HNRNPA1 HNRNPUL1 KPRP LHX2 LNX2 N4BP2L2 POU6F2 PPP1R8 PRR22 PRR35 RBM42 RIMBP3 SF3B3 SNW1 SPDYE4 SRPK1 SRPK2 TCF4 THOC5 UFL1 WDR77	26 interacting genes: CDC23 COX5B CREB5 CRYBA2 CRYBA4 CYSRT1 DOK6 FOXH1 GPS2 GRB2 HGS HNRNPF KCTD7 KRTAP26-1 MKRN3 NELFA OTX1 PATZ1 PPIL1 SMYD1 SNRPB TFAP2D TNS2 TRAPPC6A UFSP1 VGLL3
Entrez ID		51645	163154
HPRD ID		03194	14501
Ensembl ID		ENSG00000137168	ENSG00000212123
Uniprot IDs		Q9Y3C6	Q8IZ63
PDB IDs		1XWN 2K7N 2X7K 5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing Regulation Of RNA Splicing MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Processing Spliceosomal Complex Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Spliceosomal Complex Assembly Nucleic Acid Metabolic Process RNA Binding Protein-RNA Complex Assembly Catalytic Step 2 Spliceosome Nuclear Speck Nucleobase-containing Compound Metabolic Process Nucleus MRNA Binding Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Viral Genome Replication Cell Differentiation Ribonuclease E Activity Exon-exon Junction Complex Binding UFM1 Ligase Activity Oocyte Axis Specification Regulation Of RNA Metabolic Process Protein-containing Complex Assembly Positive Regulation Of RNA Splicing Negative Regulation Of Viral Genome Replication
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