IRF7 and ACADS

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		IRF7	ACADS
Name		interferon regulatory factor 7	acyl-CoA dehydrogenase short chain
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane	Nucleus Mitochondrion Mitochondrial Matrix
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Acyl-CoA Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Short-chain Fatty Acyl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Adaptive Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Signal Transduction Response To Virus Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Butyrate Catabolic Process
Pathways		DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA
Drugs		None	NADH Acetoacetyl-CoA Flavin adenine dinucleotide
Diseases		None	Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Systemic lupus erythematosus ( 26502338 27399966 28714469 ) Systemic lupus erythematosus and Systemic sclerosis ( 23740937 ) Systemic sclerosis ( 31672989 )	Allergic rhinitis ( 30013184 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Mean corpuscular volume ( 29403010 ) Metabolic traits ( 21886157 ) Metabolite levels ( 31628463 20037589 ) Red blood cell count ( 27863252 ) Red cell distribution width ( 27863252 ) Refractive error ( 32231278 ) Schizophrenia ( 30285260 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 33838163 ) Serum metabolite levels ( 23093944 33031748 ) Serum metabolite ratios in chronic kidney disease ( 29545352 ) Smoking status (ever vs never smokers) ( 30643258 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 ) Urinary metabolites (H-NMR features) ( 24586186 )
Interacting Genes		27 interacting genes: ACADS AIP ARAF CCDC47 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 SOCS1 SOCS3 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B	1 interacting genes: IRF7
Entrez ID		3665	35
HPRD ID		05441	06053
Ensembl ID		ENSG00000185507	ENSG00000122971
Uniprot IDs		B4E1B1 M9RSF4 Q92985	B4DUH1 E5KSD5 E9PE82 P16219
PDB IDs		2O61	2VIG 7Y0A 7Y0B 8SGS
GO Terms Enriched among Interactors		Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Lipopolysaccharide-mediated Signaling Pathway Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Transferase Activity Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cellular Response To Molecule Of Bacterial Origin Acetyltransferase Activity Type I Interferon-mediated Signaling Pathway Regulation Of Defense Response Canonical NF-kappaB Signal Transduction MRNA Transcription Macromolecule Metabolic Process Transcription Coregulator Activity Positive Regulation Of Immune Response Histone Acetyltransferase Complex Intracellular Receptor Signaling Pathway Protein-lysine-acetyltransferase Activity Positive Regulation Of Cytokine Production Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Endolysosomal Toll-like Receptor Signaling Pathway	Response To G1 DNA Damage Checkpoint Signaling Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Establishment Of Viral Latency Apoptosome Response To DNA Damage Checkpoint Signaling Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Cysteine-type Endopeptidase Activator Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Monocyte Differentiation Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Interferon-alpha Production Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Myeloid Cell Apoptotic Process ADP Binding Immunoglobulin Mediated Immune Response Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Interferon-beta Production Regulation Of Type I Interferon-mediated Signaling Pathway B Cell Mediated Immunity Type I Interferon-mediated Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Heat Shock Protein Binding Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Interferon-beta Production Positive Regulation Of Signal Transduction Forebrain Development Cellular Response To Stress Response To Transforming Growth Factor Beta Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Cell Communication Tube Closure Intracellular Signal Transduction Positive Regulation Of Signaling Neural Tube Closure Positive Regulation Of Type I Interferon Production Cis-regulatory Region Sequence-specific DNA Binding Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cytoplasmic Pattern Recognition Receptor Signaling Pathway Neuron Apoptotic Process