IRF7 and GCLM

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		IRF7	GCLM
Description		interferon regulatory factor 7	glutamate-cysteine ligase modifier subunit
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane	Cytosol Glutamate-cysteine Ligase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Glutamate-cysteine Ligase Activity Protein Binding Glutamate-cysteine Ligase Catalytic Subunit Binding Protein-containing Complex Binding Glutamate-cysteine Ligase Regulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Adaptive Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Signal Transduction Response To Virus Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Response To Nutrient Apoptotic Mitochondrial Changes Response To Xenobiotic Stimulus Response To Activity Cellular Response To Hepatocyte Growth Factor Stimulus Hepatic Stellate Cell Activation Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Human Chorionic Gonadotropin Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Thyroxine Stimulus Blood Vessel Diameter Maintenance Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	Glutathione synthesis and recycling Defective GCLC causes HAGGSD NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs			Glutamic acid Cysteine
Diseases
GWAS		Systemic lupus erythematosus ( 26502338 27399966 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989)	Metabolite levels ( 23823483) Ovarian cancer ( 30557369) Refractive error ( 32231278) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		27 interacting genes: ACADS AIP ARAF CCDC47 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 SOCS1 SOCS3 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B	5 interacting genes: CALM1 CFTR IRF7 OSGIN1 STOX1
Entrez ID		3665	2730
HPRD ID		05441	03106
Ensembl ID		ENSG00000185507	ENSG00000023909
Uniprot IDs		B4E1B1 M9RSF4 Q92985	P48507
PDB IDs		2O61
Enriched GO Terms of Interacting Partners?		Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Lipopolysaccharide-mediated Signaling Pathway Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Transferase Activity Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cellular Response To Molecule Of Bacterial Origin Acetyltransferase Activity Type I Interferon-mediated Signaling Pathway Regulation Of Defense Response Canonical NF-kappaB Signal Transduction MRNA Transcription Macromolecule Metabolic Process Transcription Coregulator Activity Positive Regulation Of Immune Response Histone Acetyltransferase Complex Intracellular Receptor Signaling Pathway Protein-lysine-acetyltransferase Activity Positive Regulation Of Cytokine Production Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Endolysosomal Toll-like Receptor Signaling Pathway	Regulation Of Transmembrane Transporter Activity Membrane Docking Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transporter Activity Organelle Localization By Membrane Tethering Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Otic Vesicle Morphogenesis Positive Regulation Of Cell Communication Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Signaling Positive Regulation Of Anion Channel Activity Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Establishment Of Viral Latency Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization MDA-5 Signaling Pathway Cellular Response To Nitrosative Stress Positive Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transepithelial Water Transport Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Mitochondrial DNA Metabolic Process Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Autophagosome Membrane Docking Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Negative Regulation Of Macrophage Apoptotic Process Negative Regulation Of Voltage-gated Calcium Channel Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Response To Nitrosative Stress Regulation Of Monoatomic Ion Transmembrane Transport Amelogenesis Endosome Membrane ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Multicellular Organismal Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?