IRF7 and TICAM2

Number of citations of the paper that reports this interaction (PMID 14517278)
187

Data Source:
HPRD (in vivo)

		IRF7	TICAM2
Gene Name		interferon regulatory factor 7	toll-like receptor adaptor molecule 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane	Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Early Endosome Membrane Late Endosome Membrane
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity DNA Binding Protein Binding	Signal Transducer Activity Phospholipid Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Adaptive Immune Response Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Response To Virus Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Cytokine-mediated Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-alpha Production Interferon-beta Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Type I Interferon Biosynthetic Process Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Response To Interleukin-12 Cellular Response To Lipopolysaccharide Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways		TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Toll Like Receptor 7/8 (TLR7/8) Cascade Interferon Signaling Cytokine Signaling in Immune system Factors involved in megakaryocyte development and platelet production MyD88-independent cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling Activated TLR4 signalling TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated IRF7 activation Interferon alpha/beta signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Toll Like Receptor 9 (TLR9) Cascade Innate Immune System	Activated TLR4 signalling Toll-Like Receptors Cascades TRAF6 mediated induction of TAK1 complex IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death MyD88-independent cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Innate Immune System
Drugs
Diseases
GWAS		Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		25 interactors: ACADS AIP ARAF CCDC47 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B	18 interactors: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 MEOX2 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6
Entrez ID		3665	353376
HPRD ID		05441	16313
Ensembl ID		ENSG00000185507	ENSG00000243414
Uniprot IDs		M9RSF4 Q92985	Q86XR7
PDB IDs		2O61
Enriched GO Terms of Interacting Partners?		Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Immune Response Response To Biotic Stimulus Regulation Of Cytokine Production Viral Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of Interferon-beta Production Cellular Response To Lipopolysaccharide Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Molecule Of Bacterial Origin Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Response To Bacterium Defense Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stimulus Regulation Of Interferon-beta Production Lipopolysaccharide-mediated Signaling Pathway Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Chemokine Production	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Interferon-beta Production Immune System Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Cytokine Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Interferon-beta Production Regulation Of Immune System Process Cytokine-mediated Signaling Pathway Defense Response Cellular Response To Molecule Of Bacterial Origin Response To Cytokine Response To Other Organism Response To Bacterium Response To Biotic Stimulus Response To Lipopolysaccharide Lipopolysaccharide-mediated Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Organic Substance Response To Molecule Of Bacterial Origin Regulation Of Type I Interferon Production Regulation Of Interleukin-6 Production Regulation Of Cytokine Biosynthetic Process Cellular Response To Interleukin-1 Positive Regulation Of Interferon-alpha Production Cellular Response To Organic Substance Toll-like Receptor 9 Signaling Pathway
Tagcloud ?		abolished activator amlexanox aortic augment augmentation augmented end endothelial epsilon gamma ifn ikappab ikk inducible interferon jak janus murine nitric oxide poly production stat synthase tank tbk transducer	advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb tlr4 tlr6 tollip tuberculin uganda
Tagcloud (Difference) ?		abolished activator amlexanox aortic augment augmentation augmented end endothelial epsilon gamma ifn ikappab ikk inducible interferon jak janus murine nitric oxide poly production stat synthase tank tbk transducer	advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb tlr4 tlr6 tollip tuberculin uganda
Tagcloud (Intersection) ?