ETV7 and VTN

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ETV7	VTN
Description		ETS variant transcription factor 7	vitronectin
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Golgi Lumen Symbiont-containing Vacuole Extracellular Matrix Rough Endoplasmic Reticulum Lumen Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle Protein Complex Involved In Cell-matrix Adhesion Peptidase Inhibitor Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Polysaccharide Binding Identical Protein Binding Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Animal Organ Morphogenesis Cell Differentiation	Immune Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Smooth Muscle Cell Migration Vesicle-mediated Transport Cell Migration Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Negative Regulation Of Proteolysis Positive Regulation Of Receptor-mediated Endocytosis Oligodendrocyte Differentiation Protein Polymerization Negative Regulation Of Fibrinolysis Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing Liver Regeneration Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways			Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade Developmental Lineage of Pancreatic Ductal Cells
Drugs			Abciximab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Mean platelet volume ( 27863252) Multiple sclerosis ( 31604244) Platelet count ( 27863252) Rheumatoid arthritis ( 30423114) Systemic lupus erythematosus ( 28714469) White blood cell count ( 29403010)	Advanced age-related macular degeneration ( 26691988) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731 33339817) Osteoprotegerin levels ( 25080503)
Interacting Genes		8 interacting genes: IRF4 L3MBTL1 LRPAP1 NFIA NFIB NFIC VTN WT1	50 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 DLG2 DLG3 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA2B ITGA5 ITGA8 ITGAV ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 SNTG1 TGFB1 TGFB2 TNFRSF11B UBQLN2 VEGFA
Entrez ID		51513	7448
HPRD ID		16095	01902
Ensembl ID		ENSG00000010030	ENSG00000109072
Uniprot IDs		Q9Y603	D9ZGG2 P04004
PDB IDs		9HK0	1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E 7RJ9
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Rough Endoplasmic Reticulum Lumen Glial Cell Fate Specification DNA-binding Transcription Factor Activity Exit From Mitosis DNA Replication Generation Of Neurons RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Neuron Fate Specification Glial Cell Proliferation Regulation Of Multicellular Organismal Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Symbiont-containing Vacuole Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Histone H1 Reader Activity Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Cis-regulatory Region Sequence-specific DNA Binding Retina Development In Camera-type Eye Cell Fate Specification Regulation Of MiRNA Transcription Negative Regulation Of Metabolic Process Regulation Of MiRNA Metabolic Process Cell Differentiation Involved In Salivary Gland Development Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Smooth Muscle Cell-matrix Adhesion Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development SAM Domain Binding Derlin-1-VIMP Complex Neural Precursor Cell Proliferation Positive Regulation Of RNA Metabolic Process Cellular Developmental Process Golgi Lumen Regulation Of Metabolic Process Neurogenesis Glial Cell Differentiation Principal Sensory Nucleus Of Trigeminal Nerve Development Alphav-beta3 Integrin-vitronectin Complex	Platelet Alpha Granule Lumen Integrin Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Integrin Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell-matrix Adhesion Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Locomotion Cell-cell Adhesion Positive Regulation Of Vasculature Development Cell Surface Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Epithelial Tube Formation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Signaling Receptor Binding Negative Regulation Of Multicellular Organismal Process Cell Adhesion Growth Factor Activity Angiogenesis Cell-substrate Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Regulation Of Endocytosis Regulation Of Protein Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Alphav-beta3 Integrin-PKCalpha Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Transport Positive Regulation Of Angiogenesis Positive Regulation Of Protein Localization Regulation Of Morphogenesis Of An Epithelium Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of MAPK Cascade Regulation Of Cell Migration Positive Regulation Of Morphogenesis Of An Epithelium
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