ETV7 and NFIA

Number of citations: 106 (PubMedID 35140242)
Data Source: BioGRID (proximity labelling technology, pull down)

		ETV7	NFIA
Name		ETS variant transcription factor 7	nuclear factor I A
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cell Junction
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Animal Organ Morphogenesis Cell Differentiation	Cell Morphogenesis DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Wounding Exit From Mitosis Gene Expression Glial Cell Proliferation Viral Genome Replication Glial Cell Fate Specification Neurogenesis BMP Signaling Pathway Limb Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Generation Of Neurons Cartilage Development Retina Development In Camera-type Eye Synapse Maturation Neural Precursor Cell Proliferation Ureter Development
Pathways		None	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
GWAS		Mean platelet volume ( 27863252 ) Multiple sclerosis ( 31604244 ) Platelet count ( 27863252 ) Rheumatoid arthritis ( 30423114 ) Systemic lupus erythematosus ( 28714469 ) White blood cell count ( 29403010 )	Arthritis (oligoarticular juvenile idiopathic) ( 34101054 ) Autism ( 30675382 ) Bipolar disorder ( 21738484 ) Blond vs. brown/black hair color ( 30531825 ) Celiac disease ( 20190752 25920553 30572963 ) Cobalt levels ( 26025379 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic conduction measures ( 23463857 ) Electrocardiographic traits (multivariate) ( 32602732 ) Erectile dysfunction ( 30583798 ) Feeling nervous ( 29500382 ) General risk tolerance (MTAG) ( 30643258 ) Global electrical heterogeneity phenotypes ( 29622589 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 28552196 ) Homeostasis model assessment of insulin resistance ( 33381925 ) JT interval (sulfonylurea treatment interaction) ( 27958378 ) Myopia ( 27182965 ) Number of sexual partners ( 30643258 ) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681 ) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377 ) PR interval ( 32439900 ) QRS duration ( 27577874 27659466 30679814 ) QT interval (sulfonylurea treatment interaction) ( 27958378 ) Refractive error ( 32231278 ) Regular attendance at a religious group ( 29970889 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 ) Triglyceride levels ( 32203549 )
Interacting Genes		8 interacting genes: IRF4 L3MBTL1 LRPAP1 NFIA NFIB NFIC VTN WT1	20 interacting genes: CREBBP ELK3 ERG ETV7 FBXO7 FOS FOXL1 GABARAPL1 GATA2 GATA3 KLF16 KLF8 LHX2 LHX3 NHLH1 PLEKHF2 SFN SMAD2 TBXT UBC
Entrez ID		51513	4774
HPRD ID		16095	09007
Ensembl ID		ENSG00000010030	ENSG00000162599
Uniprot IDs		Q9Y603	Q12857
PDB IDs		9HK0	Not available
GO Terms Enriched among Interactors		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Rough Endoplasmic Reticulum Lumen Glial Cell Fate Specification DNA-binding Transcription Factor Activity Exit From Mitosis DNA Replication Generation Of Neurons RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Neuron Fate Specification Glial Cell Proliferation Regulation Of Multicellular Organismal Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Symbiont-containing Vacuole Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Histone H1 Reader Activity Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Cis-regulatory Region Sequence-specific DNA Binding Retina Development In Camera-type Eye Cell Fate Specification Regulation Of MiRNA Transcription Negative Regulation Of Metabolic Process Regulation Of MiRNA Metabolic Process Cell Differentiation Involved In Salivary Gland Development Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Smooth Muscle Cell-matrix Adhesion Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development SAM Domain Binding Derlin-1-VIMP Complex Neural Precursor Cell Proliferation Positive Regulation Of RNA Metabolic Process Cellular Developmental Process Golgi Lumen Regulation Of Metabolic Process Neurogenesis Glial Cell Differentiation Principal Sensory Nucleus Of Trigeminal Nerve Development Alphav-beta3 Integrin-vitronectin Complex	Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding DNA-binding Transcription Factor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Primary Metabolic Process Transcription Regulator Complex Neuroepithelial Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Transcription Coregulator Binding Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Thyroid-stimulating Hormone-secreting Cell Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Mesoderm Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Developmental Process Positive Regulation Of Biosynthetic Process