ETV7 and L3MBTL1

Number of citations of the paper that reports this interaction (PMID 12588862)
30

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		ETV7	L3MBTL1
Gene Name		ets variant 7	l(3)mbt-like 1 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Plasma Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Nucleosome Binding Nucleosomal Histone Binding SAM Domain Binding Methylated Histone Binding Histone Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Organ Morphogenesis Cell Differentiation	Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Chromatin Modification Hemopoiesis Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: IRF4 L3MBTL1 LRPAP1 VTN	7 interactors: CBX3 ETV6 ETV7 HIST1H1B HIST4H4 RB1 SETD7
Entrez ID		51513	26013
HPRD ID		16095	16387
Ensembl ID		ENSG00000010030	ENSG00000185513
Uniprot IDs		Q9Y603	Q9Y468
PDB IDs			1OYX 1OZ2 1OZ3 2PQW 2RHI 2RHU 2RHX 2RHY 2RHZ 2RI2 2RI3 2RI5 2RJC 2RJD 2RJE 2RJF 3OQ5 3P8H 3UWN
Enriched GO Terms of Interacting Partners?		Regulation Of Binding Positive Regulation Of Binding Positive Regulation Of Interleukin-13 Biosynthetic Process Regulation Of Protein Binding Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Immune System Process T-helper 17 Cell Lineage Commitment T-helper 17 Cell Differentiation Regulation Of Beta-amyloid Clearance Receptor-mediated Endocytosis Cell Adhesion Mediated By Integrin T-helper Cell Lineage Commitment Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-13 Production CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune System Process Extracellular Negative Regulation Of Signal Transduction Regulation Of Megakaryocyte Differentiation Chromatin Modification Smooth Muscle Cell-matrix Adhesion Defense Response To Protozoan Positive Regulation Of Interleukin-4 Production Regulation Of Cell Adhesion Regulation Of Interleukin-2 Biosynthetic Process Hemopoiesis T Cell Lineage Commitment Myeloid Dendritic Cell Differentiation Negative Regulation Of Receptor Activity Endocytosis Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Migration Response To Protozoan Myeloid Dendritic Cell Activation Positive T Cell Selection T-helper Cell Differentiation Immune System Development Positive Regulation Of Interleukin-10 Production Chromatin Organization Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Interleukin-4 Production Regulation Of Complement Activation Regulation Of T-helper Cell Differentiation Regulation Of Signal Transduction Positive Regulation Of Interleukin-2 Production Endodermal Cell Differentiation	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromatin Organization Chromosome Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Modification Chromatin Remodeling Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Localization To Chromosome Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleosome Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Chromatin Assembly Organelle Organization Nucleosome Organization RNA Metabolic Process Chromatin Assembly Or Disassembly Regulation Of Centromere Complex Assembly Histone H4-K20 Demethylation Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Protein-DNA Complex Assembly Regulation Of Transcription From RNA Polymerase II Promoter Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Regulation Of Myeloid Cell Differentiation DNA Packaging Cellular Macromolecule Biosynthetic Process Negative Regulation Of Megakaryocyte Differentiation Attachment Of Mitotic Spindle Microtubules To Kinetochore Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Establishment Of Protein Localization To Chromatin
Tagcloud ?		3a 5mum 5ng annotation correlating crosstalk doxo dusp5 fc fluoruracil inducer lamp3 log2 mcf7 microenvironment modify nfkappab ntn1 nutlin opposite plk3 proof qpcr repressed snai1 synergistically tnfalpha transcriptome unc5b	advances alterations asxl1 discovery driving epigenetic existence idh1 idh2 jak leukemic modifiers modify modifying mpn mpns myeloproliferative neoplasms nevertheless predate predominant prmt5 reading reviews stat suspected technologies tet2 translational
Tagcloud (Difference) ?		3a 5mum 5ng annotation correlating crosstalk doxo dusp5 fc fluoruracil inducer lamp3 log2 mcf7 microenvironment nfkappab ntn1 nutlin opposite plk3 proof qpcr repressed snai1 synergistically tnfalpha transcriptome unc5b	advances alterations asxl1 discovery driving epigenetic existence idh1 idh2 jak leukemic modifiers modifying mpn mpns myeloproliferative neoplasms nevertheless predate predominant prmt5 reading reviews stat suspected technologies tet2 translational
Tagcloud (Intersection) ?		modify