ETV7 and L3MBTL1

Number of citations of the paper that reports this interaction (PubMedID 12588862)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		ETV7	L3MBTL1
Description		ETS variant transcription factor 7	L3MBTL histone methyl-lysine binding protein 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Chromatin Lock Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding SAM Domain Binding Histone Binding Identical Protein Binding Metal Ion Binding Histone H4K20me2 Reader Activity Histone H1 Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Animal Organ Morphogenesis Cell Differentiation	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Mitotic Nuclear Division Hemopoiesis Heterochromatin Formation Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Constitutive Heterochromatin Formation
Pathways			Regulation of TP53 Activity through Methylation
Drugs			2-(N-morpholino)ethanesulfonic acid
Diseases
GWAS		Mean platelet volume ( 27863252) Multiple sclerosis ( 31604244) Platelet count ( 27863252) Rheumatoid arthritis ( 30423114) Systemic lupus erythematosus ( 28714469) White blood cell count ( 29403010)	Antibody level in response to infection ( 25758998) Daytime sleep phenotypes ( 27126917)
Interacting Genes		8 interacting genes: IRF4 L3MBTL1 LRPAP1 NFIA NFIB NFIC VTN WT1	8 interacting genes: CBX3 ETV6 ETV7 FXR2 H1-5 H4C16 RB1 SETD7
Entrez ID		51513	26013
HPRD ID		16095	16387
Ensembl ID		ENSG00000010030	ENSG00000185513
Uniprot IDs		Q9Y603	A0A0A0MRR4 A0A3B3ISS0 A0A3F2YNZ1 B0QYN5 Q9Y468
PDB IDs		9HK0	1OYX 1OZ2 1OZ3 2PQW 2RHI 2RHU 2RHX 2RHY 2RHZ 2RI2 2RI3 2RI5 2RJC 2RJD 2RJE 2RJF 3OQ5 3P8H 3UWN 6BYB
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Rough Endoplasmic Reticulum Lumen Glial Cell Fate Specification DNA-binding Transcription Factor Activity Exit From Mitosis DNA Replication Generation Of Neurons RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Neuron Fate Specification Glial Cell Proliferation Regulation Of Multicellular Organismal Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Symbiont-containing Vacuole Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Histone H1 Reader Activity Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Cis-regulatory Region Sequence-specific DNA Binding Retina Development In Camera-type Eye Cell Fate Specification Regulation Of MiRNA Transcription Negative Regulation Of Metabolic Process Regulation Of MiRNA Metabolic Process Cell Differentiation Involved In Salivary Gland Development Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Smooth Muscle Cell-matrix Adhesion Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development SAM Domain Binding Derlin-1-VIMP Complex Neural Precursor Cell Proliferation Positive Regulation Of RNA Metabolic Process Cellular Developmental Process Golgi Lumen Regulation Of Metabolic Process Neurogenesis Glial Cell Differentiation Principal Sensory Nucleus Of Trigeminal Nerve Development Alphav-beta3 Integrin-vitronectin Complex	Chromatin Lock Complex Chromatin Remodeling Chromatin Organization Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Heterochromatin Protein Localization To Chromosome, Centromeric Region Negative Regulation Of RNA Metabolic Process Euchromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Thermosensory Behavior Negative Regulation Of Macromolecule Metabolic Process Chromosome Organization RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Structural Constituent Of Chromatin Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Vitellogenesis Regulation Of RNA Biosynthetic Process Nucleosome Nucleosome Assembly Nucleosome Organization Protein Localization To Chromosome Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Positive Regulation Of Collagen Fibril Organization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Senescence-associated Heterochromatin Focus DNA Binding Nucleus Heterochromatin Formation Regulation Of Gene Expression Glial Cell Apoptotic Process Rb-E2F Complex Peptidyl-lysine Dimethylation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Centromere Complex Assembly Potassium:chloride Symporter Activity Enucleate Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic
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