ETV7 and IRF4

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ETV7	IRF4
Gene Name		ets variant 7	interferon regulatory factor 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nuclear Nucleosome Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein-lysine N-methyltransferase Activity Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Organ Morphogenesis Cell Differentiation	Transcription, DNA-templated Peptidyl-lysine Methylation Cytokine-mediated Signaling Pathway Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Binding Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-13 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway T-helper 17 Cell Lineage Commitment
Pathways			Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Celiac disease ( 20190752) Chronic lymphocytic leukemia ( 18758461) Eye color ( 20585627) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627) Hematology traits ( 23303382) Non-melanoma skin cancer ( 23548203) Progressive supranuclear palsy ( 21685912) Sunburns ( 23548203) Tanning ( 23548203)
Protein-Protein Interactions		4 interactors: IRF4 L3MBTL1 LRPAP1 VTN	19 interactors: BATF BCL6 ETV7 FKBP4 HOXB13 HOXC11 IKBKAP IRAK1 MYD88 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TLK2 TOP1 TRAF2 YTHDC2
Entrez ID		51513	3662
HPRD ID		16095	03543
Ensembl ID		ENSG00000010030	ENSG00000137265
Uniprot IDs		Q9Y603	Q15306
PDB IDs			2DLL
Enriched GO Terms of Interacting Partners?		Regulation Of Binding Positive Regulation Of Binding Positive Regulation Of Interleukin-13 Biosynthetic Process Regulation Of Protein Binding Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Immune System Process T-helper 17 Cell Lineage Commitment T-helper 17 Cell Differentiation Regulation Of Beta-amyloid Clearance Receptor-mediated Endocytosis Cell Adhesion Mediated By Integrin T-helper Cell Lineage Commitment Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-13 Production CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune System Process Extracellular Negative Regulation Of Signal Transduction Regulation Of Megakaryocyte Differentiation Chromatin Modification Smooth Muscle Cell-matrix Adhesion Defense Response To Protozoan Positive Regulation Of Interleukin-4 Production Regulation Of Cell Adhesion Regulation Of Interleukin-2 Biosynthetic Process Hemopoiesis T Cell Lineage Commitment Myeloid Dendritic Cell Differentiation Negative Regulation Of Receptor Activity Endocytosis Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Migration Response To Protozoan Myeloid Dendritic Cell Activation Positive T Cell Selection T-helper Cell Differentiation Immune System Development Positive Regulation Of Interleukin-10 Production Chromatin Organization Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Interleukin-4 Production Regulation Of Complement Activation Regulation Of T-helper Cell Differentiation Regulation Of Signal Transduction Positive Regulation Of Interleukin-2 Production Endodermal Cell Differentiation	Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cell Activation Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Gene Expression Positive Regulation Of B Cell Activation Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Lymphocyte Activation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Activation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Cellular Nitrogen Compound Metabolic Process Cell Fate Commitment Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Developmental Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of B Cell Proliferation Negative Regulation Of Nucleic Acid-templated Transcription T-helper Cell Lineage Commitment Negative Regulation Of RNA Biosynthetic Process Immune System Process Type 2 Immune Response Epithelial Cell Development CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Organ Development Lymphocyte Differentiation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Immune Response
Tagcloud ?		3a 5mum 5ng annotation correlating crosstalk doxo dusp5 fc fluoruracil inducer lamp3 log2 mcf7 microenvironment modify nfkappab ntn1 nutlin opposite plk3 proof qpcr repressed snai1 synergistically tnfalpha transcriptome unc5b	ablation abolish adhesions attenuate chip cistrome compromise decidual decidualization decidualized deep focal forkhead foxo1 hesc igfbp1 integrating intervals o1a occupancy ontology overlap pka pr prl seq shared transcriptome wnt4
Tagcloud (Difference) ?		3a 5mum 5ng annotation correlating crosstalk doxo dusp5 fc fluoruracil inducer lamp3 log2 mcf7 microenvironment modify nfkappab ntn1 nutlin opposite plk3 proof qpcr repressed snai1 synergistically tnfalpha unc5b	ablation abolish adhesions attenuate chip cistrome compromise decidual decidualization decidualized deep focal forkhead foxo1 hesc igfbp1 integrating intervals o1a occupancy ontology overlap pka pr prl seq shared wnt4
Tagcloud (Intersection) ?		transcriptome