EVL and BDKRB1

Data Source: HiPPIP (Novel)

		EVL	BDKRB1
Name		Enah/Vasp-like	bradykinin receptor B1
Structure		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Lamellipodium Cell Projection	Endoplasmic Reticulum Plasma Membrane Membrane
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding	G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Peptide Binding
	Biological Process	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Protein Homotetramerization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Supramolecular Fiber Organization	Positive Regulation Of Leukocyte Migration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Mechanical Stimulus Cell Migration Negative Regulation Of Cell Growth Response To Lipopolysaccharide Negative Regulation Of Blood Pressure Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		None	Ramipril Captopril Zinc Enalaprilat Zinc acetate Zinc chloride Zinc sulfate, unspecified form
GWAS		Blood protein levels ( 30072576 ) White matter hyperintensities ( 32358547 ) White matter hyperintensity burden ( 25663218 )	Metabolite levels ( 23823483 )
Novel Interactors		10 novel interactors: ATG2B BDKRB1 BEGAIN C14orf132 CKB F11R GSKIP KRT17 KRT34 LRP1B	2 novel interactors: DNAJB13 EVL
Interacting Genes		36 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CEBPA CFTR CRKL DNMBP ENAH FXR1 FXR2 FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX	32 interacting genes: CERS1 DNAJB1 GABBR1 GNAQ GRIN1 HHATL HILPDA HTT INSIG1 LAPTM4B LRRC4C LTAP1 MBOAT7 MDC1 NAGPA NAP1L4 NDFIP1 NF2 OAZ2 RAE1 RETREG1 RTN4 SLC25A28 SLC39A14 SLC44A2 SLC6A8 TMEM42 TMX2 TRAM1L1 TRAT1 UQCRC1 ZNF22
Entrez ID		51466	623
HPRD ID		10942	02639
Ensembl ID		ENSG00000196405	ENSG00000100739
Uniprot IDs		A0A024R6K5 A0A2D1PGY7 Q9UI08	P46663
PDB IDs		Not available	7EIB
GO Terms Enriched among Interactors		Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Actin Filament-based Process Cytoskeleton Actin Filament Organization Fc-gamma Receptor Signaling Pathway Actin Cytoskeleton Organization Supramolecular Fiber Organization Anchoring Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Cell Migration Cell Motility Actin Polymerization Or Depolymerization Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Ephrin Receptor Binding Regulation Of Cell Projection Organization Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Component Organization Regulation Of Cell Shape Negative Regulation Of Cellular Component Organization Postsynapse Regulation Of Cell Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Integrin-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Response To Xenobiotic Stimulus Cell Junction Anatomical Structure Morphogenesis Cell Projection Organization Cytoplasm Cellular Response To Transforming Growth Factor Beta Stimulus Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Protein Tyrosine Kinase Activity Regulation Of Developmental Process Synapse Protein-containing Complex Regulation Of Actin Cytoskeleton Organization Leukocyte Migration Regulation Of Cell Projection Assembly Immune Response-activating Signaling Pathway	Endoplasmic Reticulum Membrane Membrane Ferrous Iron Transmembrane Transporter Activity Brain Development Iron Ion Transmembrane Transporter Activity Negative Regulation Of Transport Profilin Binding