EVL and TES

Number of citations of the paper that reports this interaction (PubMedID 15656790)
30

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		EVL	TES
Description		Enah/Vasp-like	testin LIM domain protein
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Lamellipodium Cell Projection	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cell Junction Protein-containing Complex Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding	RNA Binding Protein Binding Zinc Ion Binding Cadherin Binding Metal Ion Binding
	Biological Process	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Protein Homotetramerization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Supramolecular Fiber Organization	Negative Regulation Of Cell Population Proliferation
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)	Chronotype ( 30696823) Glaucoma ( 30054594 31959993) Intraocular pressure ( 29235454 30054594 31959993) Metabolite levels ( 23823483) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		36 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CEBPA CFTR CRKL DNMBP ENAH FXR1 FXR2 FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX	13 interacting genes: ACTL7A ACTN1 ALKBH4 ARAP1 ENAH EVL GRIPAP1 SOCS3 SPOCK2 SPTAN1 TLN1 VASP ZYX
Entrez ID		51466	26136
HPRD ID		10942	05833
Ensembl ID		ENSG00000196405	ENSG00000135269
Uniprot IDs		A0A024R6K5 A0A2D1PGY7 Q9UI08	A4D0U5 Q9UGI8
PDB IDs			2IYB 2XQN
Enriched GO Terms of Interacting Partners?		Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Actin Filament-based Process Cytoskeleton Actin Filament Organization Fc-gamma Receptor Signaling Pathway Actin Cytoskeleton Organization Supramolecular Fiber Organization Anchoring Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Cell Migration Cell Motility Actin Polymerization Or Depolymerization Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Ephrin Receptor Binding Regulation Of Cell Projection Organization Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Component Organization Regulation Of Cell Shape Negative Regulation Of Cellular Component Organization Postsynapse Regulation Of Cell Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Integrin-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Response To Xenobiotic Stimulus Cell Junction Anatomical Structure Morphogenesis Cell Projection Organization Cytoplasm Cellular Response To Transforming Growth Factor Beta Stimulus Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Protein Tyrosine Kinase Activity Regulation Of Developmental Process Synapse Protein-containing Complex Regulation Of Actin Cytoskeleton Organization Leukocyte Migration Regulation Of Cell Projection Assembly Immune Response-activating Signaling Pathway	Actin Binding Actin Filament Organization Supramolecular Fiber Organization Profilin Binding Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Anchoring Junction Focal Adhesion Cell Projection Cytoskeleton Actin Polymerization Or Depolymerization Vinculin Binding Stress Fiber Regulation Of Actin Filament Organization Structural Constituent Of Cytoskeleton Ruffle SH3 Domain Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Organelle Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Lamellipodium Cell-substrate Junction Assembly Actin Filament Binding Cell-substrate Junction Organization Regulation Of Cytoskeleton Organization Neuron Projection Guidance Axon Guidance Platelet Aggregation Positive Regulation Of Actin Filament Polymerization DNA N6-methyladenine Demethylase Activity Extrinsic Component Of Postsynaptic Early Endosome Membrane Regulation Of Recycling Endosome Localization Within Postsynapse Cortical Actin Cytoskeleton Cellular Component Assembly Regulation Of Cellular Component Size Cell Junction Assembly Cytosol Protein Homotetramerization Actin Filament Bundle Assembly Homotypic Cell-cell Adhesion Actin Cytoskeleton Actin Filament Bundle Organization Structural Constituent Of Postsynapse Cleavage Furrow Ingression Negative Regulation Of Receptor Clustering
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