BDKRB1 and LRRC4C

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		BDKRB1	LRRC4C
Description		bradykinin receptor B1	leucine rich repeat containing 4C
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Membrane	Extracellular Space Plasma Membrane Membrane Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Peptide Binding	Protein Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Positive Regulation Of Leukocyte Migration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Mechanical Stimulus Cell Migration Negative Regulation Of Cell Growth Response To Lipopolysaccharide Negative Regulation Of Blood Pressure Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol	Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission Synaptic Membrane Adhesion
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		Ramipril Captopril Zinc Enalaprilat Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Metabolite levels ( 23823483)	Blood protein levels ( 30072576) Cerebellum cortex volume ( 31530798) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Cerebrospinal fluid p-tau levels ( 29274321) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) High myopia ( 31816047) Iris color (L* coordinate) ( 30895295) Low myopia ( 33830181) Low myopia vs hyperopia ( 33830181) Mastocytosis (KIT D816V positive) ( 33421400) Mosquito bite size ( 28199695) Myopia ( 27182965) Order dimension in obsessive compulsive disorder ( 32424139) Osteoporosis-related phenotypes ( 20548944) Pediatric central nervous system tumors (early onset)(pleiotropy) ( 33226468) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Survival in colorectal cancer ( 26586795) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		32 interacting genes: CERS1 DNAJB1 GABBR1 GNAQ GRIN1 HHATL HILPDA HTT INSIG1 LAPTM4B LRRC4C LTAP1 MBOAT7 MDC1 NAGPA NAP1L4 NDFIP1 NF2 OAZ2 RAE1 RETREG1 RTN4 SLC25A28 SLC39A14 SLC44A2 SLC6A8 TMEM42 TMX2 TRAM1L1 TRAT1 UQCRC1 ZNF22	27 interacting genes: AGTRAP BDKRB1 BMP10 BRICD5 CLDN19 CLEC1A CLEC4G CMTM5 CREB3L4 DRAM1 EMP3 GJB2 LEPROTL1 LHFPL5 MIP NTNG1 PGAP2 PLP2 SERTM1 SMIM1 SNAP47 STX5 TWSG1 VEZT VSTM1 WHRN YIPF6
Entrez ID		623	57689
HPRD ID		02639	12303
Ensembl ID		ENSG00000100739	ENSG00000148948
Uniprot IDs		P46663	Q4JIV9 Q4JIW0 Q9HCJ2
PDB IDs		7EIB	3ZYJ
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Ferrous Iron Transmembrane Transporter Activity Brain Development Iron Ion Transmembrane Transporter Activity Negative Regulation Of Transport Profilin Binding	Membrane Gap Junction-mediated Intercellular Transport Stereocilia Ankle Link Complex Plasma Membrane Intercellular Transport Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Stereocilium Bundle Stereocilium Tip Negative Regulation Of Alpha-beta T Cell Proliferation Auditory Receptor Cell Stereocilium Organization
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