BDKRB1 and TRAT1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		BDKRB1	TRAT1
Description		bradykinin receptor B1	T cell receptor associated transmembrane adaptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Membrane	Plasma Membrane Membrane Centriolar Satellite T Cell Receptor Complex Mitotic Spindle
	Molecular Function	G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Peptide Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding
	Biological Process	Positive Regulation Of Leukocyte Migration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Mechanical Stimulus Cell Migration Negative Regulation Of Cell Growth Response To Lipopolysaccharide Negative Regulation Of Blood Pressure Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol	Negative Regulation Of Receptor Recycling Adaptive Immune Response Immune System Process Cellular Defense Response Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	PIP3 activates AKT signaling Downstream TCR signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Ramipril Captopril Zinc Enalaprilat Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Metabolite levels ( 23823483)	Autoimmune thyroid disease ( 32581359)
Interacting Genes		32 interacting genes: CERS1 DNAJB1 GABBR1 GNAQ GRIN1 HHATL HILPDA HTT INSIG1 LAPTM4B LRRC4C LTAP1 MBOAT7 MDC1 NAGPA NAP1L4 NDFIP1 NF2 OAZ2 RAE1 RETREG1 RTN4 SLC25A28 SLC39A14 SLC44A2 SLC6A8 TMEM42 TMX2 TRAM1L1 TRAT1 UQCRC1 ZNF22	13 interacting genes: BDKRB1 CD247 CD3E FYN GRB2 LCK LCP2 LYN PIK3R1 SEC22A SRC TRA TRB
Entrez ID		623	50852
HPRD ID		02639	05392
Ensembl ID		ENSG00000100739	ENSG00000163519
Uniprot IDs		P46663	C9JF66 Q6PIZ9
PDB IDs		7EIB
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Ferrous Iron Transmembrane Transporter Activity Brain Development Iron Ion Transmembrane Transporter Activity Negative Regulation Of Transport Profilin Binding	T Cell Costimulation Immune Response-activating Cell Surface Receptor Signaling Pathway Alpha-beta T Cell Receptor Complex Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Leukocyte Activation Fc-gamma Receptor Signaling Pathway Immune Response-activating Signaling Pathway Cell Activation Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway T Cell Receptor Complex Immune System Process Regulation Of Immune Response Cell-cell Junction Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Immune Effector Process Positive Regulation Of Immune Response Regulation Of Immune System Process T Cell Receptor Signaling Pathway Lymphocyte Activation Positive Regulation Of T Cell Activation Immune Response Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response T Cell Activation Peptidyl-tyrosine Phosphorylation Phospholipase Activator Activity T Cell Receptor Binding Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Phosphatidylinositol 3-kinase Binding Leukocyte Mediated Cytotoxicity Gamma-delta T Cell Activation Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Leukocyte Migration Detection Of Tumor Cell Regulation Of Cell Adhesion
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