BDKRB1 and SLC6A8

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		BDKRB1	SLC6A8
Description		bradykinin receptor B1	solute carrier family 6 member 8
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Membrane	Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Peptide Binding	Creatine Transmembrane Transporter Activity Creatine:sodium Symporter Activity Gamma-aminobutyric Acid:sodium:chloride Symporter Activity Symporter Activity Transmembrane Transporter Activity
	Biological Process	Positive Regulation Of Leukocyte Migration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Mechanical Stimulus Cell Migration Negative Regulation Of Cell Growth Response To Lipopolysaccharide Negative Regulation Of Blood Pressure Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol	Creatine Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Neurotransmitter Transport Amino Acid Transport Muscle Contraction Gamma-aminobutyric Acid Transport Creatine Transmembrane Transport Sodium Ion Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Creatine metabolism
Drugs		Ramipril Captopril Zinc Enalaprilat Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Creatine Phosphocreatine
Diseases			Non-syndromic X-linked mental retardation Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Metabolite levels ( 23823483)
Interacting Genes		32 interacting genes: CERS1 DNAJB1 GABBR1 GNAQ GRIN1 HHATL HILPDA HTT INSIG1 LAPTM4B LRRC4C LTAP1 MBOAT7 MDC1 NAGPA NAP1L4 NDFIP1 NF2 OAZ2 RAE1 RETREG1 RTN4 SLC25A28 SLC39A14 SLC44A2 SLC6A8 TMEM42 TMX2 TRAM1L1 TRAT1 UQCRC1 ZNF22	3 interacting genes: BDKRB1 CD59 CHRM5
Entrez ID		623	6535
HPRD ID		02639	02073
Ensembl ID		ENSG00000100739	ENSG00000130821
Uniprot IDs		P46663	P48029 Q59EV7 X5D9C4
PDB IDs		7EIB
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Ferrous Iron Transmembrane Transporter Activity Brain Development Iron Ion Transmembrane Transporter Activity Negative Regulation Of Transport Profilin Binding	Regulation Of Phospholipid Metabolic Process Bradykinin Receptor Activity Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Activation Of Membrane Attack Complex G Protein-coupled Acetylcholine Receptor Activity Regulation Of Phosphatidylinositol Dephosphorylation Regulation Of Cardiolipin Metabolic Process Cardiolipin Acyl-chain Remodeling Positive Regulation Of Cardiolipin Metabolic Process 1-acylglycerophosphocholine O-acyltransferase Activity Complement Binding Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Gastric Acid Secretion Regulation Of Lipid Metabolic Process G Protein-coupled Receptor Activity Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement Activation Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process Cristae Formation Regulation Of Complement Activation Regulation Of Dephosphorylation G Protein-coupled Acetylcholine Receptor Signaling Pathway Transmission Of Nerve Impulse Dopamine Transport 1-acylglycerol-3-phosphate O-acyltransferase Activity O-acyltransferase Activity Regulation Of ATP Biosynthetic Process Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Acid Secretion Regulation Of Phosphorus Metabolic Process Peptide Binding Monoamine Transport Phosphatidylglycerol Metabolic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of ATP Metabolic Process Inner Mitochondrial Membrane Organization Protein Sequestering Activity Acetylcholine Receptor Signaling Pathway Negative Regulation Of Blood Pressure Regulation Of Humoral Immune Response Postsynaptic Signal Transduction G Protein-coupled Receptor Signaling Pathway Complement Activation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
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