EVL and ENAH

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, affinity chromatography technology)

		EVL	ENAH
Description		Enah/Vasp-like	ENAH actin regulator
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Lamellipodium Cell Projection	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Lamellipodium Filopodium Cell Projection Synapse Anchoring Junction Postsynapse GABA-ergic Synapse
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Protein Domain Specific Binding WW Domain Binding
	Biological Process	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Protein Homotetramerization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Supramolecular Fiber Organization	Axon Guidance Actin Polymerization Or Depolymerization Actin Polymerization-dependent Cell Motility Postsynaptic Cytoskeleton Organization
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)	Delirium ( 29631748) Depression in smokers ( 30219690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Neuroticism ( 27067015) Obesity-related traits ( 23251661)
Interacting Genes		36 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CEBPA CFTR CRKL DNMBP ENAH FXR1 FXR2 FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX	27 interacting genes: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNMBP EVL FAT1 FYB1 GPHN HMGB1 KLHDC3 MAPK1 PFN1 PRPF40A RAC1 RAD51 ROBO4 SPTA1 TERF2IP TES VASP WAS XIRP1 YAP1 ZYX
Entrez ID		51466	55740
HPRD ID		10942	12360
Ensembl ID		ENSG00000196405	ENSG00000154380
Uniprot IDs		A0A024R6K5 A0A2D1PGY7 Q9UI08	A0A097PIC4 A0A097PID1 A0A4D6J698 Q8N8S7
PDB IDs			2HO2 2IYB 2XQN 4MY6 5N91 5N9C 5N9P 5NAJ 5NBF 5NBX 5NC2 5NC7 5NCF 5NCG 5NCP 5ND0 5NDU 5NEG 6RCF 6RCJ 6RD2 6XVT 6XXR 7A5M 7AKI 7LXE 9C66
Enriched GO Terms of Interacting Partners?		Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Actin Filament-based Process Cytoskeleton Actin Filament Organization Fc-gamma Receptor Signaling Pathway Actin Cytoskeleton Organization Supramolecular Fiber Organization Anchoring Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Cell Migration Cell Motility Actin Polymerization Or Depolymerization Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Ephrin Receptor Binding Regulation Of Cell Projection Organization Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Component Organization Regulation Of Cell Shape Negative Regulation Of Cellular Component Organization Postsynapse Regulation Of Cell Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Integrin-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Response To Xenobiotic Stimulus Cell Junction Anatomical Structure Morphogenesis Cell Projection Organization Cytoplasm Cellular Response To Transforming Growth Factor Beta Stimulus Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Protein Tyrosine Kinase Activity Regulation Of Developmental Process Synapse Protein-containing Complex Regulation Of Actin Cytoskeleton Organization Leukocyte Migration Regulation Of Cell Projection Assembly Immune Response-activating Signaling Pathway	Actin Filament Organization Actin Polymerization Or Depolymerization Supramolecular Fiber Organization Lamellipodium Cytoskeleton Proline-rich Region Binding Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Positive Regulation Of Supramolecular Fiber Organization Anchoring Junction Actin Filament-based Process Regulation Of Organelle Organization Positive Regulation Of Actin Filament Polymerization Focal Adhesion Positive Regulation Of Cytoskeleton Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Filament Polymerization Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Organelle Organization Actin Cytoskeleton Organization Regulation Of Cell Projection Assembly Regulation Of Cellular Component Size Regulation Of Ruffle Assembly Filopodium Actin-based Cell Projection Actin Cytoskeleton Positive Regulation Of Protein Polymerization Regulation Of Protein-containing Complex Assembly Regulation Of Lamellipodium Assembly Regulation Of Stress Fiber Assembly SCAR Complex SH3 Domain Binding Negative Regulation Of Cellular Component Organization Cytoplasm Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Postsynapse Cytoskeleton Organization Regulation Of Cell Motility Regulation Of Cell Shape Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Locomotion Cell Projection Morphogenesis Regulation Of Anatomical Structure Morphogenesis
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