EVL and SPTAN1

Number of citations of the paper that reports this interaction (PMID 15656790)
5

Data Source:
HPRD (in vivo, two hybrid)

		EVL	SPTAN1
Gene Name		Enah/Vasp-like	spectrin, alpha, non-erythrocytic 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium	Cytosol Fascia Adherens Spectrin Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Z Disc Vesicle Cuticular Plate Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Spectrin Binding Protein Heterodimerization Activity
	Biological Process	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Axon Guidance Actin Filament Capping
Pathways		TCR signaling Generation of second messenger molecules Axon guidance Signaling by Robo receptor Adaptive Immune System	Interaction between L1 and Ankyrins Apoptotic cleavage of cellular proteins Axon guidance Programmed Cell Death Apoptotic execution phase Nephrin interactions L1CAM interactions Caspase-mediated cleavage of cytoskeletal proteins NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP FYB FYN HCK HTT LYN PFN2 POT1 PRPF40A SEMA6A SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 WAS WASL XIRP1 ZDHHC17	48 interactors: ABI1 ABL1 ACP1 ACTA1 ACTB ADD1 ANK1 CAPN1 CASP3 CASP7 CEP63 CTNNA1 DDX24 DES DISC1 EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D MAPK6 NEFL PIN4 PLEC PLEKHA5 PRKCB PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SRC STAT1 SYN1 TANC1 TES TSSC4
Entrez ID		51466	6709
HPRD ID		10942	01684
Ensembl ID		ENSG00000196405	ENSG00000197694
Uniprot IDs		Q9UI08	Q13813
PDB IDs			2FOT 3F31 3FB2
Enriched GO Terms of Interacting Partners?		Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Axon Guidance Phagocytosis Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Signaling Pathway Regulation Of Organelle Organization Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cellular Process Chemotaxis Cell Projection Morphogenesis Cytoskeleton Organization Cell Part Morphogenesis Neuron Projection Morphogenesis Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Neuron Development Locomotion Cell Morphogenesis Involved In Differentiation Regulation Of Cytoskeleton Organization Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Cell Morphogenesis Neuron Projection Development Regulation Of Vesicle-mediated Transport Neuron Differentiation Cell Development Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cell Projection Organization Positive Regulation Of Organelle Organization Regulation Of Immune Response Actin Filament-based Process Negative Regulation Of Protein Complex Assembly Endocytosis Antigen Receptor-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Anatomical Structure Morphogenesis Regulation Of Immune System Process Actin Filament Organization Organelle Organization	Cell Morphogenesis Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Organization Axon Development Cell Projection Morphogenesis Cell Development Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Cytoskeleton Organization Neuron Differentiation Neuron Development Axon Guidance Cell Differentiation Neurogenesis Anatomical Structure Morphogenesis Generation Of Neurons Axonogenesis Neuromuscular Process Movement Of Cell Or Subcellular Component Ionotropic Glutamate Receptor Signaling Pathway Chemotaxis Organelle Organization System Development Synaptic Transmission, Glutamatergic Response To External Stimulus Anatomical Structure Development Homeostatic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Locomotion Glutamate Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Nervous System Development Membrane Depolarization Synaptic Transmission Neuron-neuron Synaptic Transmission Cellular Component Assembly Startle Response Actin Filament-based Process Developmental Process Regulation Of Excitatory Postsynaptic Membrane Potential Learning Multicellular Organismal Development Regulation Of Postsynaptic Membrane Potential Signaling Response To Wounding Cell Communication Cellular Response To Stimulus
Tagcloud ?		adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Difference) ?		adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Intersection) ?