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EVL and TERF1
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
EVL
TERF1
Description
Enah/Vasp-like
telomeric repeat binding factor 1
Image
No pdb structure
GO Annotations
Cellular Component
Stress Fiber
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Membrane
Lamellipodium
Cell Projection
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Fibrillar Center
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Spindle
Cytoskeleton
Nuclear Body
Shelterin Complex
Molecular Function
Actin Binding
Protein Binding
Profilin Binding
SH3 Domain Binding
DNA Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Microtubule Binding
DNA Binding, Bending
Telomeric DNA Binding
Identical Protein Binding
Protein Homodimerization Activity
Ankyrin Repeat Binding
G-rich Strand Telomeric DNA Binding
Biological Process
Actin Filament Organization
Cell Surface Receptor Signaling Pathway
Nervous System Development
Axon Guidance
Actin Polymerization Or Depolymerization
Animal Organ Morphogenesis
Negative Regulation Of Epithelial Cell Migration
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Cellular Component Biogenesis
Protein Homotetramerization
Positive Regulation Of Cytoskeleton Organization
Positive Regulation Of Stress Fiber Assembly
Regulation Of Actin Filament Organization
Negative Regulation Of Ruffle Assembly
Positive Regulation Of Supramolecular Fiber Organization
Telomere Maintenance
Telomere Maintenance Via Telomerase
Negative Regulation Of DNA Replication
Response To Xenobiotic Stimulus
Telomere Capping
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Meiotic Telomere Clustering
Cell Division
Telomeric D-loop Disassembly
T-circle Formation
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Shelterin Complex Assembly
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of RNA Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Telomeric D-loop Disassembly
Pathways
Generation of second messenger molecules
Signaling by ROBO receptors
Signaling by ROBO receptors
RHO GTPases Activate Formins
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
White matter hyperintensities (
32358547
)
White matter hyperintensity burden (
25663218
)
Age at first sexual intercourse (
34211149
)
Crohn's disease (
22412388
)
Leukocyte telomere length (
31171785
)
Telomere length (
33941849
)
Interacting Genes
36 interacting genes:
ABI1
ABI3
ABL1
APBB1
APBB1IP
CEBPA
CFTR
CRKL
DNMBP
ENAH
FXR1
FXR2
FYB1
FYN
HCK
HTT
LYN
PFN2
POT1
PRPF40A
RAD51
SEMA6A
SH3RF1
SPTA1
SPTAN1
SRC
TCERG1
TERF1
TES
TRIM9
WAS
WASL
XIRP1
ZDHHC17
ZNF655
ZYX
212 interacting genes:
ACAT2
ACOT7
ACY1
AFAP1L2
AHCY
AK1
AKR1A1
ALDOA
AMPD2
AMPH
ANXA2
ANXA5
ANXA8L1
APEX1
ARHGDIA
ARHGEF3
ARPP21
ASS1
ATM
BCL7B
BIN2
BLM
BRAF
C12orf43
C1orf35
CALD1
CAPNS1
CASP7
CCDC9
CDC6
CDK1
CEP85
CFL1
CKB
CORO1B
CPNE3
CRYBB1
CRYM
DBN1
DBNL
DCX
DDX19B
DDX21
DDX23
DDX24
DDX39A
DLG5
DNAAF11
DNAJB1
DNPH1
DPP3
DPYSL3
EEF1D
EIF4B
ENO2
EPB41L1
EPHX2
EVL
FANCD2
FBP1
FBXO4
FEN1
FES
FKBP8
GAMT
GAPDH
GIT1
GNL3L
GNMT
GSS
H1-1
HCLS1
HDGFL2
HEXIM1
HEXIM2
HGD
HMGN3
HMGN4
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA6
IPO5
JSRP1
KCTD7
KDM1A
KEAP1
KIFBP
KLHDC4
KPNB1
LASP1
LDHA
LDHB
LRSAM1
LYAR
MAP4
MAP7
MAPK12
MAPRE1
MCM2
MDH1
MISP
MSN
MT1X
MVK
NAP1L1
NBN
NEFL
NEK7
NME1
NME2
NOL12
NOL3
NRIP1
NUDCD2
NUDT14
NUMA1
NXNL1
OCM2
OGFR
OGT
PA2G4
PACSIN2
PAFAH1B3
PAGE2
PAICS
PAK4
PCLAF
PCP4
PEPD
PFKP
PFN2
PGD
PGLS
PGM1
PGM2
PINX1
PKM
PNMT
POT1
PPM1G
PRDX1
PRDX6
PRKCB
PTMA
PTPN5
RBMY1A1
RECQL4
RIC8A
RLIM
RNF10
RPAP3
RPL19
RTN3
RTN4
SALL1
SARS1
SBDS
SENP8
SET
SH3BP1
SH3GL2
SH3GL3
SHFL
SIRPD
SKP1
SMAD9
SMARCC2
SNCG
SOAT1
SP100
SRM
SRSF6
STUB1
SULT1C2
SUPT5H
SYK
TALDO1
TBC1D10A
TBCD
TBL1X
TCIRG1
TERT
THG1L
TINAG
TINF2
TKT
TMSB10
TMSB4Y
TNKS
TNKS2
TNPO2
TOMM34
TPI1
TRIM16
TRIP10
TRMT1
TUBB2A
TUBB3
TUBB4B
UBE2M
UTP14A
WARS1
WDR4
WFS1
YWHAG
ZBTB16
ZC3H18
ZFP36L1
ZHX1
ZNF790
Entrez ID
51466
7013
HPRD ID
10942
02975
Ensembl ID
ENSG00000196405
ENSG00000147601
Uniprot IDs
A0A024R6K5
A0A2D1PGY7
Q9UI08
A0A7I2V5T5
A0A7I2YQE7
P54274
PDB IDs
1BA5
1H6O
1ITY
1IV6
1W0T
3BQO
3L82
5HKP
5WIR
5XUP
8F0A
8F0U
8F1T
8F1U
8F21
8F26
8OX1
8W8G
Enriched GO Terms of Interacting Partners
?
Organelle Organization
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Cytoskeleton Organization
Fc Receptor Mediated Stimulatory Signaling Pathway
Actin Filament-based Process
Cytoskeleton
Actin Filament Organization
Fc-gamma Receptor Signaling Pathway
Actin Cytoskeleton Organization
Supramolecular Fiber Organization
Anchoring Junction
Non-membrane Spanning Protein Tyrosine Kinase Activity
Peptidyl-tyrosine Phosphorylation
Fc Receptor Signaling Pathway
Cell Migration
Cell Motility
Actin Polymerization Or Depolymerization
Lamellipodium
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Ephrin Receptor Binding
Regulation Of Cell Projection Organization
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of Cellular Component Organization
Regulation Of Cell Shape
Negative Regulation Of Cellular Component Organization
Postsynapse
Regulation Of Cell Morphogenesis
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Actin Filament Organization
Integrin-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Response To Xenobiotic Stimulus
Cell Junction
Anatomical Structure Morphogenesis
Cell Projection Organization
Cytoplasm
Cellular Response To Transforming Growth Factor Beta Stimulus
Stimulatory C-type Lectin Receptor Signaling Pathway
Phospholipase Binding
Cellular Response To Lectin
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Protein Tyrosine Kinase Activity
Regulation Of Developmental Process
Synapse
Protein-containing Complex
Regulation Of Actin Cytoskeleton Organization
Leukocyte Migration
Regulation Of Cell Projection Assembly
Immune Response-activating Signaling Pathway
Cytosol
Cytoplasm
Extracellular Exosome
Identical Protein Binding
Protein Binding
Nucleobase-containing Compound Metabolic Process
Nicotinamide Nucleotide Metabolic Process
Telomere Maintenance
Chromosome, Telomeric Region
Nucleobase-containing Small Molecule Metabolic Process
Purine-containing Compound Metabolic Process
Telomere Organization
Cadherin Binding
Nucleus
Negative Regulation Of Telomere Maintenance
Purine Nucleotide Metabolic Process
ADP Metabolic Process
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Chromosome Organization
Positive Regulation Of Chromosome Organization
Nucleoside Diphosphate Metabolic Process
Glycolytic Process
Pyruvate Metabolic Process
Positive Regulation Of Cellular Component Organization
Regulation Of Cellular Component Organization
ADP Catabolic Process
Nucleotide Metabolic Process
Purine Ribonucleoside Diphosphate Catabolic Process
Regulation Of Telomere Maintenance Via Telomere Lengthening
Ribonucleoside Diphosphate Catabolic Process
Nucleoside Phosphate Metabolic Process
Ficolin-1-rich Granule Lumen
Nucleoside Diphosphate Catabolic Process
Ribonucleoside Diphosphate Metabolic Process
Nucleoside Phosphate Catabolic Process
RNA Binding
Phosphate-containing Compound Metabolic Process
Microtubule Cytoskeleton Organization
Negative Regulation Of DNA Metabolic Process
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Purine Nucleotide Catabolic Process
Protein Localization To Organelle
Positive Regulation Of Protein-containing Complex Assembly
Cytoskeleton
Positive Regulation Of Organelle Organization
Organelle Organization
Catalytic Activity
Small Molecule Metabolic Process
Organophosphate Catabolic Process
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